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Leugard 22.5mg Depot Injection
Prescription Required
Salt Composition : Leuprolide Acetate
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
1 Vial(s)
Introduction to Leugard 22.5mg Depot Injection
Leugard 22.5mg Depot Injection consists of the active ingredient Leuprolide acetate. It belongs to the class of medicines called Gonadotropin Releasing Hormone (GnRH) agonists. Leugard 22.5mg Depot Injection treats prostate cancer in men, hormone-responsive breast cancer, and endometriosis (tissue that usually lines the interior of the uterus grows outside of it) and uterine fibroids (noncancerous growths of the uterus) in women.
This medicine is also used in treating premature puberty (central precocious puberty); due to certain hormonal releases, a child’s body begins to change into an adult at an early age.
It is not recommended to take this if you are allergic to Leuprolide acetate or any other ingredients, including Goserelin and Triptorlin of the medicine and products relating to gonadotropin releasing hormone (GnRH). During the treatment, the existing symptoms may worsen due to the initial sex steroid increase in the body. This will subside after the continual use of the medicine. Talk to your physician for more concerns.
This medicine is not recommended in pregnant and breastfeeding women and patients with abnormal vaginal bleeding. It is not recommended if you experience abnormal vaginal bleeding. It is not recommended for use if you experience seizure or mood disorders. Men who experience urinary blockage or who have undergone testicular excision should inform their physician.
It is advised to measure bone density at regular intervals. If you are a woman of childbearing age, use non-hormonal contraceptives while taking Leugard 22.5mg Depot Injection. Tell your doctor if you feel pressure on the spinal cord and experience urinary disorders and haematuria (blood in the urine).
Inform your doctor about any underlying medical disorders you may have before beginning therapy, such as diabetes, seizures, heart problems including chest pain, irregular heartbeats, depression, or an increased risk of osteoporosis (thinning of the bones). It is advised to inform your healthcare professional about all the medicines you are taking, including prescription, over-the-counter, herbal and vitamin supplements, before starting the therapy.
Uses of Leugard 22.5mg Depot Injection
Leugard 22.5mg Depot Injection is used in the treatment of the following:
- Prostate cancer
- Hormone-responsive breast cancer in perimenopausal (around menopause) women
- Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus)
- Central precocious puberty in children under 10 years (a child’s body begins to change into an adult too soon caused by a release of certain hormones)
Therapeutic Effects of Leugard 22.5mg Depot Injection
Leugard 22.5mg Depot Injection causes the pituitary gland's GnRH receptors to become desensitized, which lowers the amount of LH and FSH secreted. In the end, this leads to a decrease in the synthesis of sex hormones, specifically estrogen in females and testosterone in males. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Interaction of Leugard 22.5mg Depot Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications may interact with Leugard 22.5mg Depot Injection may cause undesirable side effects.
More Information about Leugard 22.5mg Depot Injection
- Keep Leugard 22.5mg Depot Injection out of sight and reach of children.
- Store in a cool, dry place, away from direct heat and light.
- Store below 25oC
- Do not refrigerate or freeze.
How to consume Leugard 22.5mg Depot Injection
Leugard 22.5mg Depot Injection is usually administered in the arm, thigh or abdomen. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advices for Leugard 22.5mg Depot Injection
Pregnancy
It is unsafe to use Leugard 22.5mg Depot Injection because it is contraindicated in pregnant women as it may cause foetal harm. Tell your doctor if you are pregnant or planning to get pregnant before taking this treatment.
Breast Feeding
It is not advised to breastfeed as it is unknown whether the drug is excreted in human milk. Inform your doctor if you are breastfeeding before taking Leugard 22.5mg Depot Injection.
Lungs
Inform your doctor if you experience any pulmonary embolism, shortness or difficulty of breath, or other underlying lung conditions. Consult your doctor for more information.
Liver
Leugard 22.5mg Depot Injection should be used cautiously in patients with liver impairment. Consult your doctor before receiving it. Notify your doctor about underlying liver conditions.
Alcohol
Consuming alcohol during the Leugard 22.5mg Depot Injection treatment may increase the risk of thinning bones and other side effects. Hence, caution should be taken. Consult your doctor for more information.
Driving
Leugard 22.5mg Depot Injection can cause drowsiness, visual disturbances, or dizziness. It is unsafe; hence, avoid driving if you are unwell.
Side Effects of Leugard 22.5mg Depot Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe rash, itching
- Osteoporosis
- Hyperglycemia
- Mood changes
- Cardiovascular risks
Common
- Injection site reactions
- Loss of appetite
- Swelling in the ankle or hand
- Difficulty sleeping, headache
- Mood swings, depression
- Weight changes
- Nausea, vomiting
- Vaginal dryness, bleeding
- Loss of interest in sexual intercourse
- Hot flushes
- Bone pain, muscle weakness
- Breast tenderness
Word of Advice
During the treatment of breast cancer, regular checkups every three months during the treatment with the combination of an aromatase inhibitor. Do not receive this injection if you experience any abnormal vaginal bleeding. Consult your doctor immediately if you or your child is suffering from a headache, even after treating it with painkillers, vision problems, buzzing, or ringing in the ear. If you have diabetes, ask your doctor to monitor your glucose and blood sugar levels regularly.
Before starting, inform your doctor if you are still menstruating. If you suffer weakness or dizziness as a side effect of Leugard 22.5mg Depot Injection, stay away from hard lifting and taxing activities. If you notice a loss of appetite, don't worry if it lasts for a day or two, but if it persists or if you are losing weight, inform your nurse or dietitian for guidance.
They may recommend supplements, dietary changes, or adjustments to eating habits to address these issues. This treatment can affect fertility in men and women. If you are worried about this, it is important to talk with your doctor before you start this treatment.
FAQs
Q 1. How does Leugard 22.5mg Depot Injection work?
Leugard 22.5mg Depot Injection decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Q 2. Who should not use Leugard 22.5mg Depot Injection?
Leugard 22.5mg Depot Injection should not be used by pregnant and breastfeeding women, people who are allergic to the medication, or people with a history of osteoporosis or bone fractures. It should also be used cautiously in people with a past of depression or mental illness.
Q 3. What should I do if I miss a dose of Leugard 22.5mg Depot Injection?
If you miss a dose of Leugard 22.5mg Depot Injection, contact your healthcare provider as soon as possible to schedule the missed dose. Do not double up on doses to make up for a missed one.
Q 4. Can Leugard 22.5mg Depot Injection cause weight gain?
Weight gain is not a common side effect of Leugard 22.5mg Depot Injection, but it may occur in some people.
Q 5. How does Leugard 22.5mg Depot Injection help with endometriosis?
Endometriosis is a condition where the tissue that lines the uterus grows outside of it, which can cause pain and other symptoms. Leugard 22.5mg Depot Injection decreases estrogen production, contributing to endometriosis tissue growth. By reducing estrogen levels, Leugard 22.5mg Depot Injection can help alleviate the symptoms of endometriosis.
Fact Box of Leugard 22.5mg Depot Injection
Molecule name: Leuprolide acetate | Therapeutic class: Antineoplastics |
Pharmacological class: Gonadotropin releasing hormone (GnRH) agonists | Indication: 1. Prostate cancer 2. Hormone-responsive breast cancer in perimenopausal (around menopause) women 3. Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus) 4. Central precocious puberty in children under 10 years (a child’s body begins to change into an adult too soon caused by a release of certain hormones)) |
| Dosage form: Injection | Habit forming: No |
References
- Takeda Pharmaceutical Company Limited, United States Food and Drug Administration(US FDA), [Revised on April 2022], [Accessed on March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/019732s045,020517s043lbl.pdf
- Takeda UK limited, European Medicines Compendium(emc), [Revised on April 2023], [Accessed on March 2024], https://www.medicines.org.uk/emc/files/pil.4651.pdf
Disclaimer
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