Liofix 2% Adr Injection contains the active ingredient Lignocaine, Adrenaline Bitartrate. Lidocaine belongs to the class of medication known as local anesthetics that numb (anesthetize) the body area. Adrenaline belongs to the class of medication known as vasoconstrictors that make the blood vessels. Liofix 2% Adr Injection is used to treat certain types of chronic pain and provides pain relief in labor, after surgery, or after acute injury.

Before taking this medication, let your physician know if you have severe allergic reactions. Report to your physician about your complete medical history, especially if you have high blood pressure or heart problems such as a slow heartbeat, hypovolaemia (decreased volume of blood), epilepsy, stroke, diabetes, thyroid problems, liver or kidney disease, inflammation at the site of injection, a rare blood pigment disorder (porphyria). It is not recommended if you are a pregnant or breastfeeding woman.

• Used as local anesthesia
• Treats certain types of chronic pain
• Provides pain relief in labor, after surgery, or after acute injury

Lidocaine works by stopping the influx of sodium ions into the membrane surrounding the nerves, preventing impulse initiation and conduction. As a result, it has an anesthetic effect and lessens pain perception. Adrenaline works by tightening and restricting blood vessels, slowing their distribution. Thereby prolonging Lidocaine’s effect.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Liofix 2% Adr Injection, reducing effectiveness by causing undesirable side effects.

• Store between 2 to 8°C in the refrigerator.
• Keep out of sight and reach of children.

Your doctor only administers Liofix 2% Adr Injection. Do not self-administer.

Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them.

Serious: 

• Severe allergic reactions
• Nerve damage
• Arachnoiditis (inflammation of a membrane that surrounds the spinal cord) 

Common: 

• Nausea and vomiting
• Dizziness
• Low and high blood pressure
• Slow heartbeat
• Blurred vision
• Shakiness
• Ringing in the ear
• Numbness of the tongue or around the mouth
• Difficulty in speaking
• Pain at the site of injection

It is suggested to inform your healthcare provider if you have allergic reactions to Liofix 2% Adr Injection to avoid life-threatening complications. Tell your doctor before the treatment commencement if you are pregnant or have blood diseases like hypovolaemia (decreased blood volume), heart problems such as a slow heartbeat, difficulty breathing, or stroke. Avoid eating or chewing within 1 hour after this injection is given to numb your mouth or throat. This is because you may accidentally bite the inside of your mouth if you are still numb.

1. Kenneth Drasner, Local Anesthetics, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 459-473.
2. KD Tripathi, Local Anaesthetics, Essentials of Medical Pharmacology, 8th Edition, 2019, 386-398.
3. AstraZeneca UK Ltd, Electronic medicines compendium (EMC), [ Revised on October 2019] [Accessed on 12th June 2023], https://www.medicines.org.uk/emc/files/pil.2397.pdf
4. GlaxoSmithKline, US Food & Drug Administration, [Revised on November 2018], [Accessed on 12th October 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021381s006lbl.pdf