LUPORAL CAPSULE

Introduction:

Luporal Capsule is a combination chemotherapy medication containing tegafur 100mg and uracil 224mg. It is used to treat metastatic colorectal cancer. Cancer is a condition in which cells multiply in an uncontrolled and abnormal manner. It is not recommended for adolescents and children. You need to inform your physician if you have heart problems, nervous disorders, diarrhea, blood clot disorders, liver or kidney disorders before taking Luporal Capsule. 

This chemotherapy medicine is contraindicated in pregnant and breastfeeding patients. Use effective birth control while being treated with this medication. Report to your physician if you experience any hypersensitive reactions after taking Luporal Capsule. Do not take more than recommended. The common side effects are low blood count, abdominal pain, vomiting, and diarrhea.

Uses of Luporal Capsule:

• Treatment of colorectal cancer

How Luporal Capsule works:

Luporal Capsule inhibits the synthesis and function of genetic material DNA and RNA and prevents the growth of cancer cells.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Luporal Capsule out of sight and reach of children.
• Store below 25°C.

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1695-1697.
2. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 864.
3. Bristol-Myers Squibb (Pty) Ltd, Published on 2001; Accessed on 05/08/2021; http://www.thethaicancer.com/PDF/Drug/Drug_information/CMT/UFT.pdf
4. Daniel IG Cubero et al; Tegafur–uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle; Published on July 2012; Accessed on 05/08/2021; https://www.ncbi.nlm.nih.gov/pubmed/22754590

How to use Luporal Capsule:

Take Luporal Capsule in a dose and duration prescribed by your doctor. Swallow the capsules whole with water. Do not crush or chew the capsules.

Safety advice:

Pregnancy:

Luporal Capsule can cause harm to the unborn baby. You need to tell your doctor if you are pregnant or planning to get pregnant before taking this medicine. 

Breastfeeding:

Luporal Capsule is contraindicated in breastfeeding patients. You need to inform your doctor if you are breastfeeding before taking this medicine. 

Liver:

You need to tell your doctor if you have any liver disorders before taking Luporal Capsule.

Kidney:

You need to tell your doctor if you have any kidney disorders before taking Luporal Capsule.

Others:

• Talk to your physician if you have heart problems, diarrhea, nervous disorders, or blood clot problems before taking Luporal Capsule. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Common:

• Diarrhea
• Abdominal pain
• Nausea, vomiting
• Low blood cell count
• Weakness, lack of energy
• Hair loss
• Rash, itching
• Infection
• Pain
• Bleeding