• Colorectal cancer

Uratuf 100mg/224mg capsule is a combination of two chemotherapy drugs: tegafur and uracil.  tegafur is absorbed into the bloodstream, converted into the active drug 5FU in the liver, and then absorbed by tumor cells. Within the cells is an enzyme that breaks down the 5FU. The uracil slows the breakdown of 5FU, which means that the 5FU stays in the cancer cells for longer.  It prevents the growth and multiplication of cancer cells and thus helps destroy the tumor.

Inform your healthcare provider about all the medicines you are taking, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Uratuf 100mg/224mg capsule and reduce its effectiveness by causing undesirable side effects.

• Store at temperatures not exceeding 25°C
• Keep the capsule away from the reach of children and pets.
• If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose.
• Do not take a double dose to compensate for a missed dose.

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the Uratuf 100mg/224mg capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take the capsules with or without food at the same time each day. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common 

• Diarrhea
• Nausea, vomiting
• Tiredness
• Risk of infection
• Fever
• Bruising and bleeding
• Anemia
• Changes in skin and nail

Serious  

• Swelling in the face, and body
• Severe skin rashes
• Severe diarrhea
• Liver injury

Do not breastfeed during the treatment with Uratuf 100mg/224mg capsule.  This medicine may increase your risk of developing a blood clot. A blood clot may cause symptoms such as pain, redness and swelling in a leg, or breathlessness and chest pain. Blood clots can be very serious so it’s important to tell your doctor straight away if you notice any of these symptoms. Your doctor will perform regular blood tests during the treatment to monitor the safety and effectiveness of the therapy. Your heart and lung function will also be checked regularly. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1695-1697.
2. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 864.
3. Bristol-Myers Squibb (Pty) Ltd, Published on 2001; Accessed on 05/05/2023;http://www.thethaicancer.com/PDF/Drug/Drug_information/CMT/UFT.pdf