Lupride Depot 22.5mg injection uses include:

• In the treatment of Prostate cancer
• Hormone-responsive breast cancer in perimenopausal (around menopause) women
• Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus)
• Central precocious puberty (a child’s body begins to change into an adult too soon caused by a release of certain hormones)

Lupride Depot 22.5mg decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications such as Quinidine, Procainamide, Amiodarone, Sotalol, Pain killers, and Antibiotics may interact with the effects of Lupride Depot 22.5mg and reduce its effectiveness by causing undesirable side effects. 

• Keep Lupride Depot 22.5mg out of sight and reach of children.
• Store in a cool, dry place, away from direct heat and light.
• Store below 25°C
• Do not refrigerate or freeze.

Lupride Depot 22.5mg injection is usually administered in the arm, thigh or abdomen. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the Lupride Depot 22.5mg injection dosage and administration frequency based on the medical condition because it differs for each person.

Lupride Depot side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious side effects of Lupride Depot 22.5mg Injection are:

• Severe rash, itching
• Shortness of difficulty of breath
• Cough with blood
• Pulmonary embolism
• Severe headache

Common side effects of Lupride Depot 22.5mg Injection are:

• Altered blood sugar and cholesterol levels
• Injection site reactions
• Loss of appetite
• Abnormal liver function
• Swelling in the ankle or hand
• Difficulty sleeping, headache
• Mood swings, depression
• Weight changes
• Nausea, vomiting
• Vaginal dryness, bleeding
• Loss of interest in sexual intercourse
• Hot flushes
• Bone pain, muscle weakness
• Breast tenderness

• During breast cancer treatment, regular checkups every three months along with an aromatase inhibitor are recommended.

• Do not take this injection if you experience abnormal vaginal bleeding, and inform your doctor if you are still menstruating before starting treatment.

• Report symptoms such as persistent headaches (even after painkillers), vision problems, or ringing in the ears to your doctor immediately.

• If you have diabetes, your doctor may monitor your glucose and blood sugar levels regularly during treatment.

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to Endocrinology: The hypothalamic-pituitary axis, 12th edition, 2011, 1122.
2. KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 243.
3. Takeda UK Limited, Electronic medicines compendium (emc), [ Revised on June 2022] [ Accessed on 12th April 2023], https://www.medicines.org.uk/emc/product/4651/smpc
4. Abbott Laboratories, US Food and Drug Administration, [Issued on  Feb 2016] [ Accessed on 12th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf