Maintane 250 injection uses:

• Prevention of recurrent preterm birth in women with a singleton pregnancy and a history of spontaneous preterm delivery
• Adjunct in treating amenorrhea (as per specific protocols)
• Management of selected gynecological hormone imbalances (off-label)

Maintane 250mg Injection helps maintain pregnancy by mimicking the action of the natural hormone progesterone. It stabilizes the lining of the uterus and prevents early contractions that may lead to preterm birth. Unlike some hormonal treatments, it does not stimulate the uterus but works gently to support fetal development. This makes it a preventive therapy for women with a history of early labor, helping to reduce the chances of recurrence.

Serious drug interactions may occur when Maintane 250mg Injection is combined with other hormone therapies, anticoagulants, or medications that affect liver enzymes.

Avoid concurrent use with:

• Estrogen-containing therapies: May increase the risk of thromboembolic events
• Rifampin or other enzyme inducers: May reduce the effectiveness of Hydroxyprogesterone
• Corticosteroids or immunosuppressants: May enhance side effects like fluid retention
• Anticoagulants (e.g., warfarin): Increased risk of bleeding or clotting irregularities
   

Contraindications include:

• Known or suspected breast or genital cancers
• History of thrombophlebitis or thromboembolic disorder
• Liver tumors or active liver disease
• Undiagnosed vaginal bleeding
• Known hypersensitivity to the drug or its components

• Storage: Store between 2°C to 8°C. Do not freeze.
• Missed Dose: Contact your doctor immediately. Do not double dose.
• Overdose: Seek medical help. Symptoms may include nausea, dizziness, or fluid retention.
• Additional Tip: Always take your dose on the same day each week as scheduled.

Maintane 250mg Injection is given as a 250 mg intramuscular injection, usually once weekly. It is administered by a healthcare professional into the upper outer quadrant of the gluteal muscle. It should not be self-injected. Food does not affect the action of this drug.

Common Side Effects

• Injection site pain or swelling
• Headache
• Nausea
• Fatigue
• Mild fluid retention
   

Serious Side Effects

• Signs of blood clots (leg pain, chest pain, difficulty breathing)
• Jaundice or liver dysfunction
• Severe allergic reaction (rash, itching, swelling)
• Vision changes or severe headache

Inj maintane 250 mg should be used under regular medical supervision. Always attend scheduled visits for monitoring and injection. Do not stop the treatment without consulting your doctor, even if you feel fine. Avoid using any hormonal products, herbal remedies, or supplements without prior approval. Inform any new doctor about your ongoing therapy, especially before surgeries or new prescriptions. Keep a record of doses taken for your and your doctor’s reference.

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021945s012lbl.pdf
3. https://www.ema.europa.eu/en/medicines/human/referrals/hydroxyprogesterone-caproate-containing-medicinal-products
4. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyprogesterone#section=3D-Conformer