Makmel 50mg Injection uses are: 

• Multiple myeloma

• Advanced breast cancer

• Advanced ovarian cancer

• Polycythemia vera

Makmel 50mg Injection is an alkylating agent. It exerts its cytotoxic action primarily due to the cross-linking of strands of DNA and RNA, as well as the inhibition of protein synthesis. It works by stopping or slowing the growth of cancer cells in your body.

1. Live Vaccines (Life threatening)
   Melphalan suppresses immune function, allowing live vaccines to cause serious infections. Live vaccines must be avoided during and after treatment.

2. Other Bone Marrow Suppressing Medicines (Severe)
   Combining melphalan with other chemotherapy drugs can greatly increase the risk of low blood counts, infections, and bleeding. Regular blood monitoring is required.

3. Radiation Therapy (Severe)
   Using radiation near the time of melphalan treatment can intensify bone marrow toxicity. Careful treatment planning is essential.

4. Clozapine (Severe)
   Both medicines can significantly lower white blood cell counts, increasing the risk of life threatening infections. This combination is usually avoided.

5. Cyclosporine or Tacrolimus (Moderate)
   These immunosuppressants may further weaken immune defenses when used with melphalan. Close monitoring for infections is advised.

6. Warfarin and Other Anticoagulants (Moderate)
   Reduced platelet counts may increase bleeding risk. INR and signs of bleeding should be monitored closely.

7. Inactivated Vaccines (Mild)
   Vaccine response may be reduced due to immune suppression. Vaccination timing may need adjustment.

• Store in a refrigerator, 2° to 8°C

• Protect the medicine from light and excessive moisture.

• Keep the medicine out of reach of children and pets

• If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Your doctor will decide on the Makmel 50mg Injection dosage and duration based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.

Makmel 50mg Injection side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common 

• Decreased blood cell count

• Nausea, vomiting, diarrhea

• Mouth ulcers

• Hair loss

Serious  

• Cardiac arrest

• Liver inflammation

• Hypersensitivity skin reactions

• Acute renal failure

• Lung inflammation

• This medicine may affect your blood levels, so your doctor may recommend regular blood tests during treatment.

• Do not take an extra dose to compensate for a missed dose.

• This medicine may cause infertility, so discuss family planning with your doctor before starting treatment.

• You may bleed, bruise, or get infections more easily while using this medicine.

• Take proper precautions to reduce the risk of injury and infections during treatment.