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Mibsar 2mg Injection
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Introduction to Mibsar 2mg Injection
Mibsar 2mg Injection is a chemotherapy medication that belongs to the class of medicines called proteasome inhibitors. It consists of the active ingredient Bortezomib. It is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma refers to the cancerous progression of plasma cells that are predominant in the bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are ineligible for blood stem cell transplant.Ā
The common side effects likely associated with MibsarĀ 2mg Injection are Pneumonia, loss of appetite, sensitivity, tingling and burning sensation of the skin, nausea, vomiting, diarrhea, mouth ulcers, constipation, muscle and bone pain, hair loss, fever, infections, itching, redness, dehydration, stomach problems, etc., Inform your physician if these side effects disturb or persist in you. Ā
Inform your doctor if you are allergic to MibsarĀ 2mg Injection and its ingredients. Do not use this medication if you have severe lung or heart problems. Before starting treatment with this medication, let your physician know if you are suffering from neuropathy (nerves malfunction), cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumor lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Inform your doctor of diabetes because this Injection can affect your blood glucose levels.
Uses of Mibsar 2mg Injection
- Treatment of multiple myeloma and mantle cell lymphoma.
Therapeutic Effects of Mibsar 2mg Injection
MibsarĀ 2mg Injection Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.
Interaction of Mibsar 2mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with MibsarĀ 2mg Injection and may cause undesirable side effects.
More Information about Mibsar 2mg Injection
- Store unopened vials in the refrigerator (2 Ā°C ā 8 Ā°C) and protect them from light.
- Keep this medicine out of sight and reach of children.
How to consume Mibsar 2mg Injection
MibsarĀ 2mg Injection is administered intravenously in your vein or subcutaneously under the skin. This injection should be given by a qualified healthcare professional experienced in the use of cytotoxic medications. Do not self-administer.Ā
Safety Advice for Mibsar 2mg Injection
Breast Feeding
MibsarĀ 2mg Injection is unsafe to use during breastfeeding. Please discuss with your physician when it is safe to restart breastfeeding after this treatment.
Alcohol
It is unsafe to consume alcohol with this medication. MibsarĀ 2mg Injection may cause excessive drowsiness with alcohol. Please consult your doctor for more advice.
Liver
Inform your physician before starting this treatment if you have Hepatitis infection or liver disease. Your physician will monitor your liver functions regularly.
Lungs
It is unknown whether MibsarĀ 2mg Injection can be given to lung failure patients. Please consult your physician if you have any lung diseases.Ā
Driving
Avoid driving or using machinery if you experience side effects like fainting, dizziness, tiredness, or blurred vision.
Pregnancy
MibsarĀ 2mg Injection is unsafe to use during pregnancy unless clearly necessary. Both women of childbearing potential and men must use an effective contraception method during and three months after treatment.
Side Effects of Mibsar 2mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Ā
Serious
- Muscle cramps
- Confusion, visual disturbances, seizures, and headache
- Breathlessness
- Swelling of feet
- Changes in heartbeat
- High blood pressure
- Fainting and tiredness
- Cough and chest tightness
Common
- Pneumonia
- Loss of appetite
- Sensitivity, tingling and burning sensation of the skin
- Nausea, vomiting, and diarrhea
- Mouth ulcers
- Constipation
- Muscle and bone pain
- Hair loss
- Fever
- Reduction in blood cell count
- Reduced kidney function
- Shivering
- Infections
- Itching and redness
- Dehydration
- Stomach problems
- Difficulty sleeping, anxiety, mood swings, depressed mood
Word of Advice
It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with MibsarĀ 2mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with bortezomib to check your blood cell counts regularly.Ā Pregnant women should not handle this Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.
FAQs about Mibsar 2mg Injection
Q1.
What is MibsarĀ 2mg Injection used for?
MibsarĀ 2mg Injection is mainly indicated to treat mantle cell lymphoma and multiple myeloma.
Q2.
Can I drive while taking MibsarĀ 2mg Injection?
MibsarĀ 2mg Injection may cause dizziness, tiredness, fainting, or blurred vision. Hence, avoid driving and operating heavy machines while this Injection.
Q3.
How is MibsarĀ 2mg Injection given?
MibsarĀ 2mg Injection is administered intravenously in your vein or subcutaneously under the skin by a doctor in a medical facility.
Q4.
Is it safe to handle MibsarĀ 2mg Injection while pregnant?
No, Pregnant women should not handle MibsarĀ 2mg Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.
Q5.
What class of chemo is MibsarĀ 2mg Injection?
MibsarĀ 2mg Injection is a targeted therapy that belongs to the class of medicines called proteasome inhibitors.
Q6.
Can I take MibsarĀ 2mg Injection when I am pregnant?
Avoid taking MibsarĀ 2mg Injection if you are pregnant, as it can cause harmful effects on the unborn baby. Females should use effective birth control methods during treatment and at least three months after treatment.
Q7.
I am suffering from a Hepatitis infection. Can I take MibsarĀ 2mg Injection?
MibsarĀ 2mg Injection should not be used in patients with hepatitis infection because they might have a repeated attack of hepatitis, which can be fatal. If you have a history of hepatitis B infection, your doctor will carefully check you for signs of active hepatitis B.
Fact Box of Mibsar 2mg Injection
Molecule name: Bortezomib | Therapeutic class: Antineoplastics agents |
Pharmacological class: Proteasome inhibitor | Indications: 1. Multiple myeloma 2. Mantle cell lymphoma |
References
- STADA, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 30 Nov 2022], https://www.medicines.org.uk/emc/files/pil.10201.pdf
- Takeda Pharmaceuticals U.S.A., Inc., [Revised on Aug 2022] [Accessed on 30 Nov 2022], https://www.velcade.com/files/pdfs/VELCADE_PRESCRIBING_INFORMATION.pdf
- Edward Chu, Cancer Chemotherapy, Langeās Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
- H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidsonās Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056
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Author Details
Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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