Nintenib 100mg Capsule uses are:

• Idiopathic pulmonary fibrosis.

• Chronic fibrosing lung diseases with a progressive phenotype

• Systemic sclerosis

Nintenib 100mg works by inhibiting receptor multiple tyrosine kinases (RTKs) enzyme that develops and progresses lung fibrosis (scarring). Inhibiting these enzymes reduces the development of fibrous tissue in the lungs.

Severe interactions

• Anticoagulants (Warfarin, Heparin, DOACs): Increased risk of serious bleeding due to additive blood thinning effects.

Moderate interactions

• Strong P-glycoprotein inhibitors (Ketoconazole, Erythromycin, Cyclosporine): May increase nintedanib levels, raising the risk of side effects.

• Strong P-glycoprotein inducers (Rifampicin, Carbamazepine, Phenytoin, St John’s wort): May reduce nintedanib effectiveness by lowering drug levels.

• Antiplatelet drugs (Aspirin, Clopidogrel): Higher chance of bleeding, especially in long-term use.

• NSAIDs (Ibuprofen, Diclofenac): Increased risk of gastrointestinal bleeding or ulcers.

Mild interactions

• Antihypertensive medicines: Blood pressure may need closer monitoring as nintedanib can raise BP.

• Hepatotoxic drugs (Methotrexate, high-dose Paracetamol): May increase liver-related side effects.

• Before starting the treatment, it is recommended to perform a liver function test

• Store at the room temperature of 20°C to 25°C

• Protect from light and moisture

• Keep out of reach and sight of children and pets.

Take Nintenib  100mg as advised by your physician. Swallow the medicine with a glass of water. Do not crush, chew, or open the medicine. Your doctor will decide the correct dose and duration for you based on your age, body weight, and disease condition. Do not stop taking this medicineunless your doctor advises you to stop.

Nintenib 100mg Capsule side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious

• Bronchitis

• Myocardial infarction

• Bleeding problems

• Pneumonia

• Major bleeding

• Yellow eyes, dark urine, pain in the upper right side of the stomach

• Severe stomach cramps, bloating, fever, and chills

• Chest pressure or pain on the left side of the body

• Increased protein in the urine (proteinuria)

Common

• Nausea, vomiting, diarrhea

• Fever

• Skin ulcer

• Gastrointestinal perforation

• Altered liver function values

• Decreased appetite

• Headache

• Weight loss

• Hypertension

• Inform your physician if you have bleeding disorders, high blood pressure, heart disease, or weak blood vessels.

• Tell your physician immediately if you develop any allergic reaction to Nintenib 100 mg.

• Inform your doctor if you have recently undergone surgery, as this medicine can affect wound healing.

• Use effective contraception during treatment and continue for at least three months after stopping the medicine.

• Report symptoms such as dark or brown urine, unusual bruising or bleeding, or yellowing of the skin or eyes without delay.

• Avoid smoking while taking Nintenib 100 mg, as it may reduce the medicine’s effectiveness.

1. Boehringer Ingelheim Pharmaceuticals. Inc, [Revised on Oct 2022] [Accessed on 05th April 2023], https://content.boehringer-ingelheim.com/DAM/f0e91cee-803b-4767-8360-af1e011fc97a/ofev-us-ppi.pdf
2. Boehringer Ingelheim, Electronics Medicines Compendium (EMC), [Revised on Aug 2021] [Accessed on 05th April 2023], https://www.medicines.org.uk/emc/files/pil.1786.pdf
3. Boehringer Ingelheim, U.S. Food and Drug Administration, [Revised on Mar 2020], [Accessed on 05th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/205832s013lbl.pdf
4. Lutz Wollin et al., Mode of action of Nintedanib capsule in the treatment of idiopathic pulmonary fibrosis, Eur Respir J. 2015 May; 45(5): 1434–1445. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416110/