Orcostin 4.5MIU Injection contains the active ingredient Colistimethate sodium. It is an antibiotic that belongs to a group of medications called polymyxins. It is used to treat certain types of infections caused by bacteria. This medicine is commonly used when other antibiotics are not suitable. It is sometimes given as an inhalation to treat chronic chest infections in patients with cystic fibrosis.  

This medicine is used when these infections are caused by specific bacteria called Pseudomonas aeruginosa. Do not use Orcostin 4.5MIU Injection if you are allergic to colistimethate sodium, colistin, or to other polymers in the medication. Inform your doctor if you have kidney problems or suffer from myasthenia gravis (weakness in skeletal muscles), porphyria (a group of disorders caused by an over-accumulation of porphyrin, which helps hemoglobin, the protein that carries oxygen in the blood), and asthma. Tell your doctor if you are pregnant, breastfeeding, or planning to get pregnant during the treatment.  

Serious allergic reactions can happen even with the first dose of Orcostin 4.5MIU Injection in some patients. They can include rapid development of rashes, swelling of the face, tongue, and neck, and inability to breathe. You should seek urgent medical attention if you experience signs of an allergic reaction. Do not stop your treatment early without consulting a doctor. Your doctor will decide how long your treatment should last.

• To treat certain bacterial infections

Orcostin 4.5MIU Injection, a polypeptide antibiotic, penetrates and disrupts the bacterial cell membrane of susceptible strains of aerobic gram-negative bacteria. It works by killing bacteria.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Orcostin 4.5MIU Injection and reduce its effectiveness by causing undesirable side effects.

• Do not store above 25°C.

• Store in the original package to protect from light.

• Keep the injection away from the reach of children and pets.

A doctor or nurse in a hospital or clinic setting will give it to you. Depending on the reason, the drug may be given by fast or slow injection into a vein. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

Common 

• Numbness or tingling

• Dizziness or loss of balance

• Changes in blood pressure

• Slurred speech

• Vision problems

• Confusion and mental problems

Serious 

• Breathing difficulty

• Respiratory tract paralysis

• Diarrhea

• Kidney damage

• This medicine may affect kidney function, so your doctor will conduct regular kidney tests to ensure safety during treatment.

• You may experience dizziness, numbness, or tingling in the hands and feet—avoid driving or operating heavy machinery if these symptoms occur.

• Inform your doctor immediately if you develop severe, ongoing, or bloody diarrhea, as this may indicate a serious side effect.

• Injection site reactions like itching, burning, swelling, or a lump under the skin can happen—report any discomfort to your healthcare provider if it persists.