Palbociclib 125 mg uses are: 

• Treatment of hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer.

Palbomed 125 mg Capsule works by blocking the protein called cyclin-dependent kinases 4 and 6, which are vital for the division and growth of cells. By blocking these proteins, this medication slows the growth and prevents the cancer cells from spreading. 

Inform your doctor about all medications, including prescribed, over-the-counter, nutritional, or vitamin supplements and herbal products that you are taking or have taken before the treatment. Concurrent use of Palbomed 125 mg Capsule with CYP3A4 inhibitors such as fentanyl has reported increased fentanyl toxicity. Certain medications may interact with the effectiveness of this drug.

• Keep Palbomed 125 mg Capsule out of sight and reach of children.
• Store at 20°C to 25°C.

Take Palbomed 125 mg Capsule exactly as prescribed by your doctor. Take this medication once a day at the same time as food. Swallow this capsule as a whole with a glass of water. Avoid crushing, breaking, or chewing the capsule.

palbociclib side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. palbomed 125mg capsule side effects include

Serious:

• Blood disorder (fever, chills, shortness of breath, weakness, bleeding, or bruising)
• Lung inflammation (chest pain, dry cough, or difficulty breathing)

Common:

• Tiredness
• Hair loss
• Dry skin, rash
• Infections
• Low blood cell counts
• Decreased of appetite
• Nausea, vomiting
• Diarrhea
• Swelling of lips and mouth
• Changes in taste
• Nose bleed
• Dry eye, blurred vision, increased tearing

During Palbomed 125 mg Capsule treatment, it is advised to avoid grapefruit and its juices and preparations containing St. John's wort. It

• Avoid grapefruit and St. John's wort: Do not consume grapefruit, its juice, or any products containing St. John's wort during Palbomed 125 mg Capsule treatment.

• Use effective contraception:

  • Females: Use birth control during treatment and for at least 3 weeks after the final dose.

  • Males: Continue birth control for at least 14 weeks after the final dose.

• Fertility concerns: This medicine may reduce fertility in both men and women. Speak to your doctor if you are planning to have children in the future.

• Regular blood tests: Your doctor may recommend routine blood tests to monitor how the medication is affecting your blood cell counts.

1. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
2. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
3. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029