Palozest 0.25mg Injection is a prescription medicine, and it is used to treat

• Postoperative nausea and vomiting.
• Chemotherapy induced nausea and vomiting.

Palonosetron is an Isoquinoline derivative that interacts with 5-HT3 receptor antagonists. It is a type of serotonin receptor antagonist, which works by blocking the action of serotonin in the body that induces nausea and vomiting. They are also effective in the prevention and treatment of nausea and vomiting in patients undergoing radiation therapy to the whole body or abdomen.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Palozest 0.25mg Injection and reduce effectiveness by causing undesirable side effects. 

• Store Palozest 0.25mg Injection in the original package at room temperature (25°C). Do not freeze.
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

The medicine will be administered to you by a qualified healthcare professional in a hospital setting. This injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors. Palozest 0.25mg Injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. If you are taking palonosetron as an oral tablet, it should be swallowed whole with a glass of water, with or without food, as directed by your healthcare provider. Do not crush, chew, or break the tablet before swallowing it.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

 Common:

• Headache
• Fatigue
• Dizziness
• Abdominal pain.

 Serious:

• Allergic reactions
• Hives
• Swollen face
• Breathing trouble
• Chest pain

Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals (such as potassium and magnesium) in your blood before taking Palozest 0.25mg Injection. Inform your doctor or nurse if you are taking any medicines that affect your heart beat because they could cause a heart beat problem when taken with Palonosetron solution for injection.

1. Accord Healthcare SLU, Electronic medicines compendium (emc), [Revised on Feb 2021] [ Accessed on 01st March 2023], https://www.medicines.org.uk/emc/files/pil.7235.pdf
2. Fresenius kabi, US Food and Drug Administration, [Revised on Dec 2018] [Accessed on 01st March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208109s001lbl.pdf
3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of disorders of bowel motility and water flux, 12th edition, 2011, 1341.
4. KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669.