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Pangraf 2mg Capsule
Last updated on 31 Mar 2026 | 09:31 AM (IST)
₹664
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Introduction to Pangraf 2mg Capsule
Pangraf 2mg Capsule contains the active substance Tacrolimus. It is an immunosuppressant that belongs to the class of medications called calcineurin inhibitors. This capsule is used along with other medications to prevent organ transplant rejection in people receiving liver, kidney, heart, or other transplants. It is also indicated to control your body’s immune response, enabling it to accept the transplanted organ.
Do not take this Pangraf 2mg Capsule if you are allergic to tacrolimus or any of the other ingredients of this medicine. Report your physician if you are allergic to any antibiotic group. Inform your doctor if you have or had a liver or heart disease before initiating the treatment. Notify your physician immediately if you develop fever, bruising under the skin (which may appear as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, and seizures after taking this medicine.
Limit exposure to sunlight and UV light while consuming Pangraf 2mg Capsule by wearing appropriate protective clothing and sunscreen with a high sun protection factor. This is because of the potential risk of malignant skin changes with immunosuppressive therapy. This medicine may cause diarrhea; inform your physician if you have diarrhea for over a day. If you need to receive any vaccinations, consult your doctor once before receiving them.
Uses of Pangraf 2mg Capsule
Pangraf 2 mg uses:
- Prevent organ transplant rejections.
Therapeutic Effects of Pangraf 2mg Capsule
Pangraf 2mg Capsule provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.
Interaction of Pangraf 2mg Capsule with other drugs
Inform your healthcare provider about all the medicines that you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Pangraf 2mg Capsule and reduce its effectiveness by causing undesirable side effects. Avoid grapefruit or grapefruit juice while taking this medicine.
More Information about Pangraf 2mg Capsule
- Store Pangraf 2mg Capsule at (25°C)
- keep the capsule away from the reach of children and pets.
- If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose.
- Do not take a double dose to compensate for a missed dose.
How to consume Pangraf 2mg Capsule
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Always take Pangraf 2mg Capsule 10's as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take these capsules on an empty stomach or at least 1 hour before or 2 to 3 hours after the meal.
Safety Advice for Pangraf 2mg Capsule
Breast Feeding
Do not consume Pangraf 2mg Capsule if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.
Alcohol
It is unsafe to consume alcohol when taking Pangraf 2mg Capsule because it may cause excessive drowsiness or liver problems.
Liver
Pangraf 2mg Capsule should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Pangraf 2mg Capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Driving vehicles or operating machinery while taking Pangraf 2mg Capsule is unsafe because it may cause drowsiness and vision problems.
Pregnancy
Based on animal studies, Pangraf 2mg Capsule can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.
Side Effects of Pangraf 2mg Capsule
Pangraf 2 mg side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Swelling in the arm or leg
- Hair loss
- Itchy skin
- Constipation, diarrhea
- Nausea, vomiting
- Anemia
- Headache
- Cough
Serious
- Increased or decreased heartbeats
- GI bleeding
- Liver Injury
- Seizure
- Acute kidney failure
- Lung infection or respiratory problems
FAQs about Pangraf 2mg Capsule
Q1.
What are the main uses of Pangraf 2mg Capsule?
Pangraf 2mg Capsule is primarily used to prevent organ rejection in patients who have undergone liver, kidney, heart, or other transplants. It helps suppress the immune response, allowing the body to accept the transplanted organ.
Q2.
What should be avoided while taking Pangraf 2mg Capsule?
Avoid alcohol, grapefruit or grapefruit juice, and prolonged sun exposure. Also, do not receive any vaccinations without your doctor’s approval while on this medication.
Q3.
What are the common side effects of Pangraf 2mg Capsule?
Common side effects include diarrhea, nausea, vomiting, constipation, hair loss, itching, headache, cough, and anemia. Serious side effects may include seizures, kidney failure, or liver injury.
Q4.
Who should not take Pangraf 2mg Capsule?
People allergic to tacrolimus or any of its ingredients, or those with a history of severe liver or heart disease, should avoid taking Pangraf unless advised otherwise by a doctor.
Q5.
What precautions are necessary before starting Pangraf 2mg Capsule?
Inform your doctor about any history of liver, heart, or lung problems, and any allergies—especially to antibiotics. Use sunscreen and protective clothing to limit UV exposure, and report any signs of infection, bruising, or unusual tiredness immediately.
References
- Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022. Accessed May 25, 2023. https://www.medicines.org.uk/emc/product/6720/smpc
- Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).; Revised 2012. Accessed May 25, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1008.
- KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 881.
Disclaimer
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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