Quick Summary
Pazliz 400mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
₹7651
MRP: ₹9468.75
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30 TABLET(s) IN A BOTTLE
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₹7651
MRP: ₹9,468.75
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Introduction
Pazliz 400mg Tablet contains the active substance pazopanib. It is an antineoplastic drug that belongs to the class of tyrosine kinase inhibitors. Pazliz Tablet is primarily used in adults to treat advanced kidney cancer or cancer that has spread to other organs. It is also indicated for certain forms of soft-tissue sarcoma, a type of cancer that affects the supportive tissues of the body.
Pazliz Tablet use is mainly focused on slowing down or stopping the growth and spread of cancer cells by blocking specific proteins involved in tumor development. This makes it an effective treatment option for patients with advanced cancers.
The Pazliz 400mg Tablet price may vary depending on the pharmacy, brand availability, and location. Patients are advised to consult their healthcare provider for proper guidance before starting the treatment.
Uses
- Advanced renal cell carcinoma
- Advanced soft tissue sarcoma
How Pazliz 400mg Tablet works
Pazliz 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is an anticancer medication that belongs to the category of tyrosine kinase inhibitors. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.
Interaction of Pazliz 400mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Pazliz 400mg tablet and reduce its effectiveness by causing undesirable side effects.
Storage conditions
- Store Pazliz 400mg tablet in room temperature (25°C)
- Keep the injection away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.
- Do not take a double dose to make up for a forgotten dose.
How to take Pazliz 400mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Pazliz 400mg tablet at least two hours after a meal or one hour before a meal.
Safety Advice for Pazliz 400mg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking Pazliz 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
It is unknown whether it is safe to consume alcohol when taking Pazliz 400mg tablet. Consult your doctor for more advice.
Liver
Pazliz 400mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary for moderate liver failure. Inform your physician if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Pazliz 400mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Driving or operating heavy machinery is unsafe after taking Pazliz 400mg tablet because you may feel dizzy, drowsy, or have blurred vision.
Pregnancy
Pazliz 400mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for at least 2 weeks after your last dose is necessary.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Hypertension
- Hair color change
- Increased glucose levels
- Decreased weight, decrease in appetite
- Diarrhea
- Nausea, vomiting
- Muscle and joint pain
- Headache
- Shortness of breath
- Tiredness
Serious
- Heart problems
- Bleeding from the anus, mouth
- Hypothyroidism
- Interstitial lung disease
- Infections
Expert Tips
-
Do not drink grapefruit juice during the treatment, as it may increase the risk of side effects.
-
Male patients with female partners of reproductive potential should use effective contraception during treatment and for at least 2 weeks after the last dose to prevent pregnancy.
-
Take the tablet at the same time every day for best results.
-
Your doctor will conduct regular lab tests to check the effectiveness of the medicine.
FAQs about Pazliz 400mg Tablet
Q1.
What if I forgot to take Pazliz 400mg tablet?
If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose. Do not take a double dose to make up the forgotten dose.
Q2.
Can Pazliz 400mg tablet induce liver toxicity?
Yes, long-term use of Pazliz 400mg tablet may induce liver toxicity or severe liver failure. Inform your physician if you have any liver disorders before starting treatment with this medicine. Your doctor may advise you to take certain blood tests to check your liver function periodically.
Q3.
Does Pazliz 400mg tablet change hair color?
Hair color change is a common side effect of Pazliz 400mg tablet therapy which usually develops gradually during a few months of therapy. Consult your doctor for more advice.
Q4.
Is anemia a side effect of Pazliz 400mg tablet?
Pazliz 400mg tablet can reduce the number of red blood cells, which transport oxygen throughout the body. A low number of red blood cells is called anemia. This may make you feel tired and short of breath. Tell your doctor or nurse if you have these symptoms.
Q5.
What are the benefits of Pazliz 400mg tablet?
Pazliz 400mg tablet is used to treat certain types of cancer (kidney, soft tissue sarcoma). It decreases the blood supply to the cancer tumor to slow tumor growth.
Fact Box of Pazliz 400mg Tablet
|
Molecule name |
Pazopanib |
|
Therapeutic class |
Antineoplastics |
|
Pharmacological class |
Tyrosine kinase inhibitor |
|
Indications |
1. Advanced renal cell carcinoma 2. Advanced soft tissue sarcoma |
References
- Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
- Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
- Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Disclaimer
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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