• Advanced renal cell carcinoma

• Advanced soft tissue sarcoma

Pazolong 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is an anticancer medication that belongs to the tyrosine kinase inhibitor class. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factor (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.

Taking Pazolong 400mg Tablet (pazopanib) with any of the following medicines can change the effect of either of them and may increase the risk of side effects.

Ketoconazole, Itraconazole, Clarithromycin (Oral Route) Life-threatening
Do not use together.
These strong CYP3A4 inhibitors may increase pazopanib levels in the blood and raise the risk of serious side effects such as liver damage and heart rhythm problems.

Rifampicin (Oral Route) Life-threatening
Avoid using together.
Concomitant use may reduce the blood levels of pazopanib and make the cancer treatment less effective.

Carbamazepine, Phenytoin, Phenobarbital (Oral Route) Life-threatening
Do not use together.
These medicines may lower pazopanib levels and reduce its anticancer effect.

St. John’s Wort (Herbal Route) Life-threatening
Avoid using together.
This herbal product may decrease pazopanib levels and lead to treatment failure.

Medicines that prolong QT interval such as Amiodarone or Sotalol (Oral Route) Life-threatening
Do not use together unless strictly advised.
Concomitant use may increase the risk of serious heart rhythm disturbances.

• Store Pazolong 400mg tablet in room temperature (25°C)

• Keep the injection away from the reach of children and pets.

• If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.

• Do not take a double dose to make up for a forgotten dose.

Your doctor will decide the pazolong tablet dose and treatment duration based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects its absorption. Take Pazolong 400mg tablet at least two hours after a meal or one hour before a meal. 

Pazolong tablet side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common

• Hypertension

• Hair color change

• Increased glucose levels

• Decreased weight, decrease in appetite

• Diarrhea

• Nausea, vomiting

• Muscle and joint pain

• Headache

• Shortness of breath

• Tiredness

Serious

• Heart problems

• Bleeding from the anus, mouth

• Hypothyroidism

• Interstitial lung disease

• Infections

• Do not drink grapefruit juice during the treatment with this medicine, as this may increase the chance of side effects.

• Male patients with female partners with reproductive potential should use effective contraception during the treatment and at least 2 weeks after the last dose to prevent pregnancy.

• Take the tablet at about the same time each day. Your doctor will regularly do lab tests to check whether the medicine works for you.

1. Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
2. Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
3. Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.