Pegstim 6mg is a prescription PFS Injection, and it is used to treat 

• Decrease the chance of infection caused by low levels of white blood cells in patients with certain types of cancer (non-myeloid) receiving bonemarrow suppressing anti-cancer drugs.
• To increase the survival rate in patients receiving radiation therapy that suppresses bone marrow activity.

Pegstim 6mg Injection PFS is a colony-stimulating factor that exerts its action by acting on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation. 

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Pegstim 6mg Injection PFS and reduce effectiveness by causing undesirable side effects. 

• Store Pegstim 6mg Injection PFS in a refrigerator (2°C – 8°C). Do not freeze.
• Do not shake this Injection
• Discard the Injection if it has been stored at room temperature for more than 48 hours.
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor immediately for advice.

The Injection will be administered in the fatty tissues just under your skin (subcutaneously) by a qualified healthcare professional in a hospital setting. The dose and frequency of administration will be decided by your doctor based on your disease condition and other factors.  

If your physician decides that Pegstim 6mg Injection PFS can be administered at home by you or your caregiver, then read the “Instructions for use” carefully from the package insert that comes with the Injection. Your doctor or other healthcare professionals will train you on self-administration. Do not administer the Injection if you have not been trained and not sure about the administration procedure.

Side effects are unwanted symptoms caused by Injections. Even though all drugs cause side effects, not everyone gets them. 

 Common

• Pain in the bones, joints and muscles
• Pain at the site of Injection
• Itchiness and skin rash
• Nausea
• Headaches
• Dizziness and tiredness

 Serious

• Inflammation of Aorta
• Capillary leak syndrome (plasma leaks out of tiny blood vessels)
• Hypersensitivity reactions
• Changes in urine color
• Swelling in hands, feet, face, and abdomen
• Difficulty in breathing
• Sickle cell anemia

Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes. Pegstim 6mg Injection is a dose-based injection, and it should not be administered in patients weighing less than 45kg from a pre-filled syringe.  Read the package insert carefully if you are self-administering the Injection. This Injection may cause lung, liver or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.

1. Package leaflet: Information for the user Neulasta 6 mg solution for injection pegfilgrastim. [Revised 2021 Jun] [cited 2023 Feb 23]. Available from: https://www.medicines.org.uk/emc/files/pil.10091.pdf
2. Patient Information Neulasta ® (nu-las-tah) (pegfilgrastim) injection Single-Dose Prefilled Syringe. (2021). Available at: https://www.pi.amgen.com/-/media/Project/Amgen/Repository/pi-amgen-com/Neulasta/neulasta_ppi_pt_english.pdf  [Accessed 23 Feb. 2023].
3. HIGHLIGHTS OF PRESCRIBING INFORMATION. (2019). Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125031s198lbl.pdf   [Accessed 23 Feb. 2023].
4. Parker, S.D. and Jacobs, T.F. (2020). Pegfilgrastim. [online] PubMed. Available at: https://www.ncbi.nlm.nih.gov/books/NBK532893/  [Accessed 23 Feb. 2023].