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PEMGEM 500MG INJECTION
Salt Composition : Pemetrexed
Manufacturer : DR REDDY'S LABORATORIES LTD
Origin of Medicine : India
Introduction to Pemgem 500mg Injection
Pemgem 500mg injection is an anticancer medicine containing the active ingredient Pemetrexed. It belongs to the medication class known as an antifolate agent. It is used to treat non-small cell lung cancer and malignant pleural mesothelioma (cancers of the lungs and chest). This medicine is given alone or in combination with another anticancer medicine, such as cisplatin. Your doctor may prescribe corticosteroids, folic acid, and vitamin B12 to limit the side effects.
Blood tests will be taken before each infusion to determine whether your kidney and liver functions are adequate and whether you have enough blood cells to receive this medicine. Before starting treatment with Pemgem 500mg injection, it is very important to tell your physician if you currently or previously had any medical conditions of kidney problems, heart disorders, or fluid accumulation in the lungs. Report to your doctor if you recently had or currently having radiotherapy or any vaccination before taking this medication.
Inform your doctor immediately if you are planning to get pregnant or think you may be pregnant. Use effective birth control during the treatment and at least six months after the last dose of Pemgem 500mg injection. In men, it is recommended not to father a child during and up to 3 months after the treatment. So it is advised to get suggestions about fertility concerns from your doctor. This medication is not recommended for adolescents and children under 18 years of age.
Uses of Pemgem 500mg Injection
- Malignant pleural mesothelioma
- Non-small cell lung carcinoma
Therapeutic Effects of Pemgem 500mg Injection
Pemgem 500mg inhibits the mechanism required for cell division and replication by blocking specific enzymes involved in folate metabolism (essential for cell replication) and DNA synthesis, which will prevent the cancer cells from growing and multiplying.
Interaction of Pemgem 500mg Injection with other drugs
Inform your healthcare provider about all your medicines, including prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Certain medications such as may interact with Pemgem 500mg and reduce effectiveness by causing undesirable side effects.
More Information about Pemgem 500mg Injection
- Keep the tablets away from light and moisture.
- Store refrigerated at 2°C to 8°C.
- Keep the tablets out of the reach of children and animals.
How to consume Pemgem 500mg Injection
Pemgem 500mg injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advices for Pemgem 500mg Injection
Do not take Pemgem 500mg if you are pregnant because it may cause harm to the unborn baby. Consult your doctor before starting the treatment.
It is unsafe to breastfeed while taking Pemgem 500mg because it can cause toxicity to the baby. If you are breastfeeding a baby, it has to be discontinued. Please consult your physician for more advice.
Consult your doctor if you experience any symptoms like; shortness of breath, blockage, or inflammation in the lining of the lung while taking Pemgem 500mg.
Inform your physician about any underlying liver disorders before taking Pemgem 500mg, as this medication should be used with caution in liver disease patients.
It is unknown whether consuming alcohol while taking an Pemgem 500mg injection is safe. Please speak with your physician.
While taking Pemgem 500mg, driving or using machines is unsafe because it may cause nausea, fatigue, vomiting, etc. Talk to your doctor for more information.
Side Effects of Pemgem 500mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
- Blood infection
- Severe allergic reaction
- Breathlessness, intense chest pain or cough with bloody sputum
- Reduced neutrophil granulocytes (white blood cells)
- Kidney failure
- Pharyngitis (a sore throat)
- Abnormal liver function
- Nausea, vomiting, diarrhea
- Redness, swelling or sores in the mouth
- Loss of appetite, sensation
- Reduced hemoglobin level
- Increased skin pigmentation
- Watery and inflamed eyes, taste change
- Muscle weakness
- Skin rash
- Hair loss
Word of Advice
Discuss your fertility problem with the doctor since, in men, it is advised not to father a child during and after the 3 months of treatment. So it is advised to get suggestions about fertility concerns. Avoid planning for the pregnancy. If you experience any symptoms mentioned as a side effect, consult your doctor immediately. Notify your doctor immediately if you have undergone any radiotherapy or taken any vaccines and other medications before starting with Pemgem 500mg because it might reduce the effectiveness of this medicine and may cause side effects. Inform your doctor if you have or had any history of heart disease, kidney problems,s or liver problems.
Q 1. What should I tell my doctor before starting Pemgem 500mg?
Before starting Pemgem 500mg, you should tell your doctor about any medical conditions you have, especially kidney or liver problems, as well as any medications you are taking, including over-the-counter drugs and supplements
Q 2. .Can children or adults take Pemgem 500mg?
No, Pemgem 500mg is not recommended for children or adults under 18 years. Talk with your doctor for more information.
Q 3. How often do I need to have blood tests while on Pemgem 500mg?
You will need to have regular blood tests while taking Pemgem 500mg to monitor your blood cell counts, blood uric acid level, and kidney function.
Q 4. Can I continue my normal activities while on Pemgem 500mg?
It depends on your circumstances and how you feel. You should discuss your activities and any concerns with your healthcare provider while under the treatment of Pemgem 500mg.
Q 5. How is Pemgem 500mg administered?
A healthcare provider gives Pemgem 500mg as an intravenous (IV) injection. The dose and frequency of the injections will depend on the patient's condition and other factors.
Q 6. Why do I feel nauseous while taking Pemgem 500mg ?
Nausea is a common side effect of chemotherapy drugs, including Pemgem 500mg . This happens because chemotherapy drugs can affect the lining of the stomach, leading to nausea and vomiting.
Fact Box of Pemgem 500mg Injection
Molecule name: Pemetrexed
Therapeutic class: Anti-Cancer
Pharmacological class: Antifolate agent
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs,7th edition, 2013, 863.
- Eagle Pharmaceuticals, US Food and Drug Administration, [ Revised on Feb 2020] [ Accessed on 27 - March - 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209472s000lbl.pdf
- Seacross Pharmaceuticals Ltd, Electronic medicines compendium (emc), [ Accessed on 27 - March - 2023], https://www.medicines.org.uk/emc/files/pil.8887.pdf
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