Piciclib 75mg uses for Treatment of hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer.

Piciclib 75mg works by blocking the protein called cyclin-dependent kinases 4 and 6, which are vital for the division and growth of cells. By blocking these proteins, this medication slows the growth and prevents the cancer cells from spreading.  

Inform your doctor about all medications including prescribed, over-the-counter, nutritional or vitamin supplements and herbal products that you are taking or have taken before the treatment. Concurrent use of Piciclib 75mg with CYP3A4 inhibitors such as fentanyl has reported increased fentanyl toxicity. certain medications may interact with the effectiveness of this drug. 

• Keep Piciclib 75mg out of sight and reach of children.

• Store at 20°C to 25°C.

Take Piciclib 75mg exactly as prescribed by your doctor. Take this medication once a day at the same time with food. Swallow this capsule as a whole with a glass of water. Avoid crushing, breaking, or chewing the capsule. 

Piciclib 75mg side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Serious

• Blood disorder (fever, chills, shortness of breath, weakness, bleeding, or bruising)

• Lung inflammation (chest pain, dry cough, or difficulty breathing)

Common

• Tiredness

• Hair loss

• Dry skin, rash

• Infections

• Low blood cell counts

• Decreased of appetite

• Nausea, vomiting

• Diarrhea

• Swelling of lips and mouth

• Changes in taste

• Nose bleed

• Dry eye, blurred vision, increased tearing

• Food and Herbal Interactions: Avoid consuming grapefruit, its juice, and products containing St. John’s wort during Piciclib 75mg treatment, as they can interfere with the medicine’s effectiveness.

• Contraceptive Precautions: Use effective birth control during treatment and for at least three weeks after the last dose (females) and fourteen weeks after the last dose (males) to prevent pregnancy.

• Fertility Considerations: Piciclib 75mg may reduce fertility; discuss any reproductive or family planning concerns with your physician before starting treatment.

• Monitoring: Your doctor may advise regular blood tests to mo

1. Pfizer Limited, Electronic medicines compendium (emc), [Revised on June 2021] [ Accessed on 26 Nov 2022], https://www.medicines.org.uk/emc/files/pil.4449.pdf
2. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
3. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
4. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029