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Pirfenex 400mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Substitutes
Fibrodone 400mg Tablet
LUPIN LTD
₹ 33.50/tablet
13% cheaper
Introduction
Pirfenex 400mg tablet belongs to the medication class known as transforming growth factor inhibitors. It contains an active ingredient called Pirfenidone, which is the main Pirfenex composition. This medicine is widely used to treat idiopathic pulmonary fibrosis (IPF), a serious lung disorder where the tissues of the lungs become scarred and inflamed, leading to breathing difficulties.
The Pirfenex 400mg dosage is usually decided by your doctor based on your medical condition and response to treatment. Patients often look into Pirfenex 400mg Tablet reviews to understand others’ experiences with the drug. Many highlight Pirfenex 400mg benefits, including improved breathing capacity and slowing the progression of IPF.
When comparing Pirfenex vs Esbriet, both contain Pirfenidone as the active ingredient, but there may be differences in brand, availability, and price. Patients sometimes consider a Pirfenex 400 substitute if required due to cost or availability issues. Speaking of cost, the Pirfenex 400mg price can vary depending on pharmacy and location, so checking updated rates before purchase is recommended.
For those who prefer digital convenience, many trusted platforms allow you to buy Pirfenex 400mg online with a valid prescription.
Uses
Pirfenex tablet uses are in the treatment of the following:
- Idiopathic pulmonary fibrosis
How Pirfenex 400mg Tablet works
Pirfenex 400mg tablet works to reduce the production and accumulation of extracellular matrix (ECM) proteins, which contribute to the fibrosis and stiffening of lung tissue. This helps to slow the progression of the disease and improve lung function.
Interaction of Pirfenex 400mg Tablet with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications, such as Ciprofloxacin and Fluvoxamine, may interact with the effects of Pirfenex 400mg tablet and reduce its effectiveness by causing undesirable side effects.
Storage conditions
- Keep the Pirfenex 400mg tablet out of sight and reach of children.
- Store at a temperature of 25°C
- Store in the original package
- Do not refrigerate
How to take Pirfenex 400mg Tablet
Take Pirfenex 400mg tablet in a dose and duration prescribed by your doctor. Swallow the tablets whole with water. Take the tablet after a meal at the same time each day to reduce the side effects. Do not crush or chew the tablets. Do not drink grapefruit juice while taking this medication.
Safety Advice for Pirfenex 400mg Tablet
Breast Feeding
It is not recommended while taking Pirfenex 400mg tablet. Because the medicine can pass into breast milk, potentially harming a nursing infant. Consult the doctor for more information.
Alcohol
It is unknown if drinking alcohol while taking a Pirfenex 400mg tablet is safe. Please speak with your physician.
Liver
Before starting the treatment, notify your doctor if you have any past severe liver problems. It is recommended to perform a liver function test because Pirfenex 400mg tablet should be used with caution in patients with liver disease.
Lungs
Consult your doctor if you experience any upper respiratory tract infection while taking Pirfenex 400mg tablet.
Driving
Pirfenex 400mg tablet may cause dizziness or sleepiness. So it is unsafe to drive while you are under this treatment.
Pregnancy
Pirfenex 400mg tablet may cause harm to the unborn baby. Tell your doctor if you are pregnant or planning to get pregnant before taking this medicine.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Pirfenex 400mg side effects are
Serious side effects of Pirfenex 400mg Tablet are:
- Severe allergic reactions (swelling of face, lips, or tongue, wheezing, feeling faint)
- Liver problems (yellowing of skin or eyes, dark urine, bruising, or bleeding)
Common side effects of Pirfenex 400mg Tablet are:
- Nausea, vomiting
- Loss of appetite, tiredness
- Diarrhea, indigestion
- Headache, dizziness
- Skin reactions after exposure to sunlight
- Infections
- Weight loss
- Difficulty sleeping
- Changes in taste
- Cough
- Stomach pain, constipation, feeling bloated, heartburn
- Itchy, dry skin
- Muscle pain, joint pain
- Chest pain, shortness of breath
Expert tips
-
Consult your doctor immediately if you experience any side effects.
-
Notify your doctor right away if you notice:
-
Dark or brown urine
-
Unusual bruising
-
Excessive bleeding
-
Jaundice (yellowing of skin or eyes)
-
-
Avoid smoking while taking Pirfenex 400mg tablet, as it may reduce the medicine’s effectiveness.
-
Avoid exposure to sunlight, including sunlamps.
-
Use sunscreen daily and wear protective clothing (cover head, arms, and legs) to reduce sun exposure.
-
Perform a liver function test before starting treatment to ensure safety.
FAQs about Pirfenex 400mg Tablet
Q1.
What is the mechanism of action of Pirfenex 400mg tablet work?
Pirfenex 400mg tablet works by reducing inflammation and fibrosis in the lungs. It inhibits the production of certain molecules that cause scarring and stiffening of the lung tissue.
Q2.
What is the recommended duration for taking Pirfenex 400mg tablet?
Pirfenex 400mg tablet is a long-term medication that is taken indefinitely for treating IPF. Anyways, the duration of treatment may vary depending on the individual patient's response to the medication and other factors.
Q3.
Who should not take Pirfenex 400mg tablet ?
Pirfenex 400mg tablet is not recommended for pregnant or breastfeeding women and those with severe liver or kidney disease.
Q4.
What dosage of Pirfenex 400mg tablet should I take?
It is important to note that the dosage of Pirfenex 400mg tablet may vary based on factors such as the patient's age, weight, renal function, and other medications they may be taking. Dosage adjustments may be necessary based on side effects or changes in the patient's condition. As with all medications, it is important to follow the dosage instructions provided by your healthcare provider and to consult with them if you have any questions or concerns.
Q5.
What should I do if I miss a dose of Pirfenex 400mg tablet?
If you miss a dose of Pirfenex 400mg tablet, take it as soon as you remember. Skip the missed dose and continue with your regular dosing schedule.
Q6.
What tests should I take before starting Pirfenex 400mg tablet?
Your doctor will recommend you to take a liver function test before starting the cycles with Pirfenex 400mg tablet to monitor the functioning level.
Fact Box of Pirfenex 400mg Tablet
|
Molecule name |
Pirfenidone |
|
Therapeutic class |
Antifibrotic drugs |
|
Pharmacological class |
Transforming growth factor inhibitor |
|
Indication |
Idiopathic pulmonary fibrosis |
References
- Roche Products Limited, Electronic medicines compendium (emc), [Revised on Nov 2020] [Accessed on 1st April 2023] https://www.medicines.org.uk/emc/files/pil.2731.pdf
- Genentech USA, Inc, US Food and Drug Administration, [Revised on Jan 2017], [Accessed on 1st April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208780s000lbl.pdf
- Pirfenex Tablets; Cipla Ltd; Ciplamed; Accessed on 1st April 2023; https://www.ciplamed.com/content/pirfenex-tablets
Disclaimer
MrMed’s primary intention is to ensure that its consumers get accurate and trustworthy information that is reviewed by experts. The contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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