Pomamac 2mg Capsule is used in the treatment of:

• Multiple myeloma: Used as part of combination treatment to control the growth of abnormal plasma cells in the bone marrow, particularly in patients whose disease has progressed after previous treatments.

The doctor decides the appropriate treatment combination, dose and duration based on the patient's condition, previous treatments and response to therapy.

Pomamac contains Pomalidomide, an immunomodulatory agent that acts on the immune system and the growth of abnormal plasma cells.

Pomalidomide binds to a protein called cereblon, which is part of a protein complex involved in regulating cell growth and survival. This interaction promotes the breakdown of specific proteins, including Ikaros and Aiolos, which are important for the survival of multiple myeloma cells.

By reducing these proteins, Pomalidomide helps stop abnormal plasma cells from multiplying and promotes their destruction. It also modifies immune activity and supports the body's natural ability to recognise and attack abnormal cells.

Pomamac may interact with certain medicines and affect how they work. Inform your doctor about all medicines you are taking, particularly:

• Strong CYP1A2 inhibitors: Medicines such as fluvoxamine and ciprofloxacin may increase Pomalidomide exposure in the body. Your doctor may need to avoid or adjust treatment when these medicines are used together.

• Anticoagulants: Medicines such as warfarin may require closer monitoring because Pomalidomide treatment can increase the risk of blood clots, and patients may also receive medicines to prevent them.

• Medicines that increase bleeding risk: Certain medicines, including antiplatelet agents and non-steroidal anti-inflammatory medicines (NSAIDs), may increase bleeding concerns, particularly when platelet counts are low.

• Other medicines that affect blood cell counts: Combining Pomamac with certain cancer treatments or medicines that suppress bone marrow activity may increase the risk of anaemia, neutropenia and thrombocytopenia.

• Store Pomamac below 25°C.

• Keep the capsules in their original packaging to protect them from moisture and light.

• Store the medicine in a dry place, away from direct heat and sunlight.

• Keep it out of the reach of children.

• Do not use the capsules after the expiry date printed on the packaging.

• Take Pomamac exactly as prescribed by your oncologist.

• Swallow the capsule whole with water. Do not break, open, crush or chew it.

• It can generally be taken with or without food.

• Take it at approximately the same time each day.

• If you miss a dose, contact your doctor or pharmacist for instructions. Do not take an extra capsule to compensate for a missed dose.

• If the capsule is accidentally opened or damaged, avoid contact with its contents. Wash the affected area thoroughly with soap and water if contact occurs.

Pomalidomide treatment is usually given in cycles. The prescribed dose and treatment schedule depend on the patient's condition and response. The 2 mg capsule strength does not necessarily represent the total daily dose.

Pomamac may cause side effects, although not everyone experiences them.

Common side effects

• Fatigue and weakness

• Anaemia

• Low white blood cell count (neutropenia)

• Low platelet count (thrombocytopenia)

• Constipation

• Nausea and vomiting

• Diarrhoea

• Fever

• Back pain

• Upper respiratory tract infections

• Shortness of breath

Serious side effects

Contact your doctor immediately if you experience:

• Severe blood cell abnormalities: Unusual bruising, bleeding, persistent fever or signs of infection may indicate low platelet or white blood cell counts.

• Blood clots: Pain or swelling in one leg, sudden chest pain or difficulty breathing may indicate deep vein thrombosis or pulmonary embolism.

• Liver problems: Yellowing of the skin or eyes, dark urine, abdominal pain or unusual tiredness may indicate liver injury.

• Severe allergic reactions: Swelling of the face, lips or throat, difficulty breathing or widespread skin reactions require immediate medical attention.

• Severe skin reactions: Blistering, peeling skin or widespread rashes should be assessed immediately.

• Take Pomamac exactly as prescribed. Do not change the dose or treatment schedule without consulting your oncologist.

• Attend all scheduled blood tests to monitor your red blood cells, white blood cells and platelet counts.

• Inform your doctor about any history of blood clots, liver disease or recurring infections before starting treatment.

• Follow the pregnancy-prevention precautions strictly throughout treatment and for the recommended period after stopping it.

• Report fever, unusual bruising, bleeding or persistent infections promptly.

• Follow your doctor's advice regarding medicines prescribed to reduce the risk of blood clots.

• Avoid donating blood or sperm during treatment and for the recommended period after stopping Pomalidomide.

• Handle damaged or broken capsules carefully and avoid direct contact with their contents.

• Do not share your medicine with anyone, even if they have a similar condition.