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Pulmonext 5mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Introduction
Pulmonext 5mg Tablet contains an active component, Ambrisentan. This medication is used to treat pulmonary arterial hypertension (PAH). PAH is a condition characterised by high blood pressure in the arteries that carry blood from the heart to the lungs. It helps to relax and widen the blood vessels in the lungs, reducing the strain on the heart and improving blood flow. It is typically prescribed as a long-term treatment for PAH to improve exercise capacity and delay disease progression. By targeting the underlying mechanisms of PAH, this medication can slow down the progression of the disease.
This can result in a longer period of better health and quality of life for individuals with PAH. Ambrisentan can be used as a monotherapy (used alone) or in combination with other PAH medications, depending on the severity of the condition and the patient's response to treatment. In general, it is considered well-tolerated by most patients. While there can be side effects, they are usually manageable, and healthcare providers can monitor and adjust treatment accordingly.
If an individual has a known allergy or hypersensitivity to Pulmonext 5mg Tablet or its components, its use should be avoided. Inform your healthcare provider about any pre-existing medical conditions, such as gastrointestinal disorders, liver disease, kidney disease, or other health conditions. These may require special precautions or adjustments in the use of this medication. This medication can sometimes lead to fluid retention and worsening heart failure symptoms in some individuals. People with a history of heart failure require close monitoring while taking the medication.
There have been reports of decreases in red blood cell counts (anaemia) and decreases in white blood cell counts while taking Pulmonext 5mg Tablet. Regular blood tests are required during the treatment. Grapefruit juice can increase the levels of this medication in the body, which could potentially lead to an increased risk of side effects. Therefore, consuming grapefruit juice should be avoided while taking this medication. Pulmonext 5Mg Tablet price varies by location and retailer. Buy Pulmonext 5Mg Tablet online through various platforms like MrMed at affordable prices.
Uses
Pulmonext 5Mg Tablet uses to treat the following:
- Pulmonary arterial hypertension
How Pulmonext 5mg Tablet Works
Pulmonext 5mg Tablet is an endothelin receptor antagonist that exerts its therapeutic effect by selectively blocking the effects of endothelin, a substance that causes blood vessels to constrict and tighten. By inhibiting endothelin's action, this medication promotes vasodilation (widening of blood vessels) in the pulmonary arteries, reducing the resistance to blood flow and lowering pulmonary arterial pressure. This mechanism of action improves blood flow to the lungs, lessens the strain on the right side of the heart, and ultimately enhances exercise capacity and quality of life in individuals with pulmonary arterial hypertension (PAH).
Interaction of Pulmonext 5mg Tablet with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications, including birth control pills and medications that affect liver enzymes, may interact with Pulmonext 5mg Tablet, reducing effectiveness by causing undesirable side effects.
Storage Conditions
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to take Pulmonext 5mg Tablet
Pulmonext 5mg Tablet is usually taken orally once daily, with or without food. It's important to follow the prescribed dosage provided by your healthcare provider and to take the medication at the same time each day to maintain consistent levels in your system. Swallow the tablet whole with water and do not crush or chew it.
Safety Advice for Pulmonext 5mg Tablet
Breast Feeding
It is unknown if Pulmonext 5mg Tablet passes into breast milk. Because of the potential for harm to the infant, women should avoid breastfeeding while taking it.
Alcohol
There are no known interactions between Pulmonext 5mg Tablet and alcohol. However, excessive alcohol consumption can have negative effects on PAH and overall health. It's advisable to discuss alcohol consumption with your healthcare provider and consider moderation.
Liver
Pulmonext 5mg Tablet is primarily metabolised by the liver. Individuals with severe liver impairment should not take this medication. Regular liver function tests are typically recommended to monitor the medication's effects on the liver.
Lungs
Pulmonext 5mg Tablet is primarily used to treat pulmonary arterial hypertension (PAH). It's important to inform your healthcare provider about any lung conditions you have, as they will need to assess whether the benefits of the medication outweigh any potential risks.
Driving
PAH can cause symptoms like dizziness and fatigue, which could impact driving safety. If you experience any side effects that affect your ability to drive, it's best to avoid driving until you feel safe to do so.
Pregnancy
Pulmonext 5mg Tablet is known to cause serious birth defects and is contraindicated during pregnancy.
Side Effects
Pulmonext 5Mg Tablet side effects like all medications, although not everyone will experience them.
Serious:
- Liver problems
- Anaemia (low red blood cell count)
- Fluid retention leads to heart failure exacerbation in certain individuals
- Potential birth defects if taken during pregnancy
Common:
- Headache
- Nasal congestion
- Flushing
- Peripheral oedema (swelling in arms, legs, hands, or feet)
Expert tips
-
Regular liver function tests are necessary as the medication may cause liver problems.
-
It is contraindicated during pregnancy due to the risk of birth defects.
-
Monitor closely for fluid retention, especially if you have a history of heart failure.
-
Regular blood tests may be needed to check for anaemia or low white blood cell counts.
-
Inform your healthcare provider about all medicines you are taking to avoid drug interactions.
-
Share any existing lung conditions so your doctor can weigh the benefits and risks carefully.
-
Discuss lifestyle habits such as alcohol use and smoking with your doctor.
FAQs about Pulmonext 5mg Tablet
Q1.
Is Pulmonext 5mg Tablet a cure for pulmonary arterial hypertension (PAH)?
No, Pulmonext 5mg Tablet is not a cure for PAH. It is a medication that helps manage the symptoms and slow down the progression of the disease, improving quality of life and exercise capacity.
Q2.
Does Pulmonext 5mg Tablet cause weight gain?
Weight gain, particularly due to fluid retention, is a potential side effect of Pulmonext 5mg Tablet. However, not everyone experiences this side effect. Regular monitoring by your healthcare provider can help manage any weight-related concerns.
Q3.
Can Pulmonext 5mg Tablet be used in children with PAH?
The safety and efficacy of Pulmonext 5mg Tablet in pediatric patients have not been well established, and its use in children and adolescents is limited. Its use should be carefully considered under the guidance of a healthcare professional.
Q4.
What should I do if I miss a dose of Pulmonext 5mg Tablet?
If you miss a dose, take it as soon as you remember. However, if it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Q5.
Can Pulmonext 5mg Tablet be taken with other PAH medications?
Yes, Pulmonext 5mg Tablet can be used alone or in combination with other PAH medications, depending on your specific condition and treatment plan. Your healthcare provider will determine the best approach for your situation.
Q6.
How long does it take for Pulmonext 5mg Tablet to start working?
The effects of Pulmonext 5mg Tablet can vary from person to person. Some individuals may start experiencing improvements in exercise capacity and symptoms within a few weeks, while for others, it might take longer. Consistency in taking the medication as prescribed is important for optimal results.
Fact Box
|
Molecule name: |
Ambrisentan |
|
Therapeutic class: | Antihypertensive Agents |
|
Pharmacological class: | Endothelin receptor antagonist |
|
Indications: | Pulmonary arterial hypertension |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Anti-arrhythmic drugs, 12th edition, 2011, 834.
- Cipla EU Ltd, Electronic medicines compendium (EMC), [Revised on 16 Aug 2022] [ Accessed on 28th August 2023], https://www.medicines.org.uk/emc/product/11697/smpc#gref
- Gilead Sciences,, US Food and Drug Administration, [Revised on November 2020], [Accessed on 28th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2020/022081Orig1s042ltr.pdf
Disclaimer
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Author Details
Written By
Dr. Deva Prasath S.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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