R-thrombo 1500000IU contains an active component such as Streptokinase. It is a medication that is used for the treatment of blood clot-related conditions.It is used to treat deep vein thrombosis, a condition where blood clots form in the deep veins, usually in the legs.This medication is used to treat pulmonary embolism, which occurs when a blood clot travels to the lungs and blocks blood flow.  In certain cases, It is used to treat arterial blood clots, such as those that can cause ischemic strokes.  R-thrombo 1500000IU is used to maintain the patency of dialysis fistulas or grafts, which are artificial connections between an artery and a vein used in patients with kidney failure who require dialysis.

Individuals with a known hypersensitivity or allergic reaction to R-thrombo 1500000IU or any components of the medication should not take R-thrombo 1500000IU. Do not take this medication in the presence of active internal bleeding, such as gastrointestinal bleeding or recent surgery. Patients with a history of hemorrhagic stroke should not take this medication. Do not take this medication if you are having severe kidney dysfunction. Old-age patients should always consult a healthcare provider because of the higher risk of bleeding due to age-related changes in blood vessels and other medical conditions. R-thrombo 1500000IU is generally not recommended for use in children because there is limited study on its safety and efficacy in pediatric populations.

R-thrombo 1500000IU is used in the following:

• Myocardial Infarction (heart attack)
• Deep vein thrombosis (DVT)
• Pulmonary embolism
• Arterial clots
• Peripheral arterial disease
• Thrombosis in dialysis fistulas/grafts

R-thrombo 1500000IU operates as a thrombolytic agent by interacting with plasminogen, a precursor protein in the blood. Through its binding, It triggers plasminogen's conversion into plasmin, an active enzyme that dismantles fibrin, the structural framework of blood clots, leading to their dissolution. Promoting this clot breakdown restores blood flow by eliminating blockages in blood vessels, which is essential for preventing tissue damage and related complications.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with R-thrombo 1500000IU, reducing effectiveness by causing undesirable side effects.

• Store at room temperature, between  2°C to 8°C
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

R-thrombo 1500000IU is administered through the intravenous (IV) route or intracoronory. It may also be delivered through an arterial catheter for more localized treatment. Healthcare professionals perform administration following prescribed dosages and guidelines.

R-thrombo 1500000IU causes some side effects like all medications, although not everyone will experience them. 

Serious

• Bleeding
• Allergic Reactions
• Hypotension (Low Blood Pressure)
• Fever and Chills

Common

• Bleeding at Injection Site
• Nausea and Vomiting
• Fever
• Allergic Skin Reactions
• Minor Drop in Blood Pressure
• Flushing

Monitor for signs of allergic reactions, including rash, itching, swelling, and difficulty breathing. Discontinue R-thrombo 1500000IU and seek medical attention immediately if any allergic symptoms occur. Use with caution in individuals with a history of bleeding disorders, recent surgery, ulcers, or other conditions that might increase bleeding risk. Monitor blood pressure during administration and address any hypotensive episodes. Follow the prescribed dosage as directed by your healthcare provider. Individuals with severe liver or kidney impairment should talk to healthcare providers to assess their condition and determine the appropriate course of action. Use this medication with caution in individuals who have recently undergone surgery, or had significant trauma.

1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, bleeding, and thrombosis, 7th edition, 2013, 626.
2. Tetris Pharma Ltd, Electronic medicines compendium (emc), [Revised on 18th Dec 2021] [ Accessed on 25th 2023], https://www.medicines.org.uk/emc/product/13114/smpc#gref
3. Adinarayana Kunamneni, Thaer Taleb Abed Abdelghani, Poluri Ellaiah; streptokinase--the drug of choice for thrombolytic therapy; Journal of Thrombosis and Thrombolysis; Published on Feb 2007; Accessed on 25/08/2023; https://pubmed.ncbi.nlm.nih.gov/17111203/