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Rabipur Vaccine
Prescription Required
Salt Composition : Rabies Antiserum
Manufacturer : GLAXO SMITHKLINE PHARMACEUTICALS LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Rabipur Vaccine
The Rabipur Vaccine contains active components called rabies antiserum. It belongs to the drug class as Immunoglobulin. It is also known as rabies immune globulin (Rabies antiserum) or rabies immune serum and is a medical treatment used to prevent the development of rabies in individuals who have been exposed to the rabies virus. One of the most significant advantages of the Rabipur Vaccine is that it provides immediate passive immunity against the rabies virus.
It is a crucial component of post-exposure prophylaxis (PEP) for individuals who have been bitten, scratched, or otherwise exposed to a potentially rabid animal. Neutralising the rabies virus at the exposure site can help prevent it from entering the nervous system and progressing to symptomatic rabies.
Individuals with a known history of severe allergic reactions (anaphylaxis) to any component of the rabies antiserum or any previous rabies vaccination should not receive the Rabipur Vaccine.
Suppose an individual has previously completed a full course of rabies vaccination (pre-exposure prophylaxis). In that case, they may not require it in the event of a subsequent exposure, as their immune system should already have an antibody response to the rabies virus. Always consult a healthcare provider before using it in old age or with children.
Uses of Rabipur Vaccine
Rabipur Vaccine is used in the following:
- Post-exposure prophylaxis of rabies infection
Therapeutic Effects of Rabipur Vaccine
The Rabipur Vaccine works by providing immediate protection through pre-formed antibodies that neutralise the rabies virus at the exposure site. This prevents the virus from entering nerve cells and allows the individual's immune system to generate antibodies through vaccination, ultimately preventing rabies infection.
Interaction of Rabipur Vaccine with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the Rabipur Vaccine, reducing effectiveness by causing undesirable side effects.
More Information about Rabipur Vaccine
- Stored Rabipur Vaccine at room temperature from 2°C to 8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Rabipur Vaccine
Rabipur Vaccine is typically administered through the intramuscular (IM) route. It is injected directly into the muscle, usually at or near the site of potential rabies exposure, to provide immediate passive immunity against the rabies virus. Always consult with a healthcare professional for proper administration guidance based on the specific circumstances of exposure.
Safety Advices for Rabipur Vaccine
Pregnancy
It is unknown what the safety of Rabies antiserum is. It is important to consult a healthcare provider before using Rabipur Vaccine, as its safety during pregnancy is unknown. The benefits of preventing rabies must outweigh any potential risks to the fetus.
Breast Feeding
The antibodies are not significantly excreted in breast milk in significant amounts. Breastfeeding women should consult a healthcare provider before using Rabipur Vaccine.
Lungs
Rabipur Vaccine and vaccination are typically safe for individuals with lung conditions. If you have respiratory issues or lung conditions, consult a healthcare provider before using it.
Liver
Rabipur Vaccine is generally safe for individuals with liver conditions, as it does not require processing by the liver. Consult a healthcare provider if you have any liver dysfunction.
Alcohol
Alcohol consumption is generally unsafe while receiving the Rabipur Vaccine as it can impair the immune system's response to the vaccine, potentially reducing its effectiveness.
Driving
You may experience side effects such as pain or discomfort at the injection site after receiving Rabipur Vaccine. Always consult a healthcare provider before using it before driving.
Side Effects of Rabipur Vaccine
Rabipur Vaccine causes some side effects like all medications, although not everyone will experience them.
Serious side effects of Rabipur Vaccine are:
- Severe allergic reactions
Common side effects of Rabipur Vaccine are:
- Allergic reactions
- Neurological side effects
- Other serious reactions
Word of Advice
Before taking the Rabipur vaccine, inform your healthcare provider if you have any allergies, especially regarding medications used in rabies treatment, as severe allergies may require special consideration. Additionally, if you have conditions that weaken your immune system, like HIV, or if you are taking medications that suppress immunity, it's important to know that the rabies vaccine may not work as effectively, so discuss this with your healthcare provider.
If you are pregnant or breastfeeding, you must talk with your healthcare provider before starting rabies treatments. They will assess the risks and benefits to determine the best course of action for your specific situation.
If you have liver or kidney issues, inform your healthcare provider, as this may impact your treatment plan. After receiving rabies treatment, it's advisable to avoid alcohol consumption for a period. If you experience any pain or discomfort at the injection site, it's best not to drive immediately after the treatment.
If you have clotting disorders or multiple bite wounds, exercise extra caution, as there may be a higher risk of bleeding at the injection sites. Always consult your healthcare provider for personalised advice, as rabies is a serious concern, and timely and appropriate treatment is essential to ensure your safety.
FAQs
Q 1. What is the source of rabies antibodies in the Rabipur Vaccine?
Rabies antibodies in the Rabipur Vaccine are typically derived from the blood plasma of individuals or animals immunised against rabies. The antibodies are purified and concentrated for medical use.
Q 2. Can the Rabipur Vaccine be administered multiple times if needed?
Yes, in cases where additional exposure to the rabies virus occurs or if there is a delay in initiating rabies vaccination, additional doses of the Rabipur Vaccine can be administered as necessary.
Q 3. How long does the protection from the Rabipur Vaccine last?
The protection provided by the Rabipur Vaccine is immediate but relatively short-lived. It helps bridge the gap until the individual's immune system generates its antibodies through rabies vaccination. The vaccine offers long-term immunity.
Q 4. What should I do if I experience side effects after receiving the Rabipur Vaccine?
If you experience any unusual or severe side effects after receiving Rabipur Vaccine, seek immediate medical attention. Healthcare providers are trained to manage and treat adverse reactions promptly.
Q 5. Are there any age restrictions for receiving the Rabipur Vaccine?
Rabipur Vaccine can be administered to individuals of all ages, including children and the elderly, depending on the specific circumstances of rabies exposure. Doses and treatment plans may be adjusted based on age and weight.
Q 6. Can the Rabipur Vaccine be used as a substitute for rabies vaccination?
No, the Rabipur Vaccine is not a substitute for rabies vaccination. Both treatments are essential components of post-exposure prophylaxis (PEP), and they work together to provide comprehensive protection. It provides immediate immunity, while the vaccine offers long-term protection.
Fact Box of Rabipur Vaccine
Molecule name: Rabies antiserum | Therapeutic class: Immune Serum |
Pharmacological class: Immunoglobulin | Indications: Post-exposure prophylaxis of rabies infection |
References
- Thomas Moulenat et al., Purified Vero Cell Rabies Vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019, Trop. Med. Infect. Dis., 2020, 5, 40, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157209/pdf/tropicalmed-05-00040.pdf
- KD Tripathi, Vaccines, Antisera and lmmuneglobulins, Essentials of Medical Pharmacology, 8th Edition, 2019, 978-986.
- Kedrion Biopharma Inc., US Food and Drug Administration, [Revised on 2020] [Accessed on 11th September 2020],https://www.fda.gov/media/106795/downloa
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