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Regolieva 40mg Tablet
Prescription Required
Salt Composition : Regorafenib
Manufacturer : Allieva Pharma Pvt. Ltd.
Origin of Medicine : India
28 Tablet(s) In A Bottle
Introduction to Regolieva 40mg Tablet
Regolieva 40mg Tablet is a targeted therapy containing the active constituent regorafenib. It is used to treat colon cancer, rectal cancer, liver cancer, and gastrointestinal stromal tumours (GIST) (a type of cancer of the stomach and bowel). Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner.
Talk to your doctor if you have any liver disorders, infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headaches, or seizures, or if you recently had or are going to have a surgical procedure before taking this medicine. Regolieva 40mg Tablet is not recommended for adolescents and children.
Avoid drinking grapefruit juice while taking this medicine, as it can affect the way this medicine works. Use effective birth control during the treatment and for at least eight weeks after the last dose. Talk to your doctor if you are on a salt-controlled diet, as Regolieva 40mg Tablet contains sodium.
Uses of Regolieva 40mg Tablet
Regolieva 40mg Tablet is used in the treatment of the following:
- Colorectal cancer has started to spread to other parts of the body
- Gastrointestinal stromal tumours (GIST) (a type of stomach and bowel cancer)
- Liver cancer in adult patients who have already undergone treatment with Sorafenib (anticancer medicine)
Therapeutic Effects of Regolieva 40mg Tablet
Regolieva 40mg Tablet binds to tyrosine kinase receptors and inhibits the VEGF (vascular endothelial growth factor) and EGFR (epidermal growth factor receptor) receptors on the cell surface. By binding to these receptors, this medication blocks an important pathway that promotes cell division. This helps to prevent the growth and multiplication of cancer cells.
Interaction of Regolieva 40mg Tablet with other drugs
It is important to inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Regolieva 40mg Tablet, potentially affecting their effectiveness or causing side effects.
More Information about Regolieva 40mg Tablet
- Keep this medicine out of sight and reach of children.
- Store at room temperature between 20°C to 25°C.
How to consume Regolieva 40mg Tablet
Always take Regolieva 40mg Tablet exactly as your doctor has told you. Swallow the tablets whole with water. Do not crush or chew the tablets. Avoid drinking grapefruit juice while taking this medicine.
Safety Advices for Regolieva 40mg Tablet
Pregnancy
Regolieva 40mg Tablet is not safe to be used in pregnancy. Consult with your doctor for advice.
Breast Feeding
It is not recommended to breastfeed while taking Regolieva 40mg Tablet. Consult with your doctor for advice.
Lungs
Regolieva 40mg Tablet may cause lung-related side effects, such as interstitial lung disease. It should be used with caution in patients with pre-existing lung conditions. Consult with your doctor for advice.
Liver
Regolieva 40mg Tablet should be used with caution in patients suffering from liver diseases. Consult with your doctor for advice.
Alcohol
It is not recommended to consume alcohol while taking Regolieva 40mg Tablet, as it may increase the risk of liver damage and other side effects. Consult with your doctor for advice.
Driving
Regolieva 40mg Tablet may cause dizziness, fatigue, or visual disturbances, which could impair your ability to drive. Avoid driving or operating heavy machinery if you experience these symptoms. Consult with your doctor for advice.
Side Effects of Regolieva 40mg Tablet
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Severe:
- Liver problems (yellowish discolouration of skin and whites of the eyes, dark urine, confusion)
- Bleeding
- Infection (high fever, cough with or without sputum, pain when urinating, unusual vaginal discharge, shortness of breath)
- Stomach and bowel problems (severe stomach pain, blood in vomit, red or black stools)
Common:
- Low blood cell count
- Decreased appetite, weight loss
- Nausea, vomiting
- High blood pressure
- Voice changes
- Diarrhea
- Dry mouth, painful tongue, mouth sores
- Changes in liver function
- Weakness, lack of energy
- Pain, redness, blisters and swelling of palms of the hands or soles of the feet
- Dehydration
- Hair loss, dry skin
- Headache
- Heartburn
- Low levels of potassium, phosphate, calcium, sodium or magnesium in blood
- Shaking
- Numbness, tingling
- Taste disorders
- Muscle spasms
- Abnormal clotting condition
- Protein in the urine
Word of Advice
Talk to the doctor if the patient has any liver disorders, infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headache, seizures or recently had or is going to have a surgical procedure before taking Regolieva 40mg Tablet. It is not recommended for adolescents and children. Avoid drinking grapefruit juice while taking Regolieva 40mg Tablet, as it can use the effectiveness of the medications. Avoid taking this medicine if the patient is planning for pregnancy or during pregnancy and breastfeeding, as it causes harmful effects for the developing baby.
FAQs
Q 1. Is Regolieva 40mg Tablet chemotherapy?
Regolieva 40mg Tablet is used as a chemotherapy to treat cancer of the stomach, colon or rectal when other medications and treatments become ineffective.
Q 2. How is the Regolieva 40mg Tablet taken?
Regolieva 40mg Tablet is taken as prescribed by the doctor. It is taken once daily along with the food at a fixed time and does not stop this medication without the proper advise of the doctor.
Q 3. Can I take grapefruit juice while taking a Regolieva 40mg Tablet?
No, patients are advised not to take grapefruit juice while taking this medication as it decreases the effectiveness of the medicine.
Q 4. Is it safe to use Regolieva 40mg Tablet during pregnancy?
It is unsafe to use this medication if the patient is planning for pregnancy or during pregnancy as it causes harmful effects on the developing baby
Q 5. What is the use of the Regolieva 40mg Tablet?
It is used to treat colon cancer, rectal cancer, liver cancer, and gastrointestinal stromal tumours (GIST) (a type of cancer of the stomach and bowel).
Fact Box of Regolieva 40mg Tablet
| Molecule name: Regorafenib | Therapeutic Class: Antineoplastic Agent |
| Pharmacological Class: Multikinase Inhibitor | Indications: 1. Colorectal cancer (metastatic) 2. Gastrointestinal stromal tumours (GIST) that are unresectable or have metastasised 3. Hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib |
References
1. Bayer plc, Electronic medicines compendium (emc), [Revised on August 2021] [ Accessed on 5th August 2021], https://www.medicines.org.uk/emc/files/pil.1263.pdf
2. Bayer Healthcare Pharmaceuticals Inc, US Food and Drug Administration, [Revised on April 2018] [ Accessed on 5th August 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf
3. Thomas J Ettrich, Thomas Seufferlein; Regorafenib; Recent Results in Cancer Research; Published on 2014; Accessed on 01/12/2021; https://pubmed.ncbi.nlm.nih.gov/24756792/
4. Dirk Strumberg, Beate Schultheis; Regorafenib for cancer; Expert Opinion on Investigational Drugs; Published on June 2012; Accessed on 01/12/2021; (https://pubmed.ncbi.nlm.nih.gov/22577890/ )
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