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Rexafor 20mg Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Introduction to Rexafor 20mg Injection
Rexafor 20mg Injection is an antineoplastic containing the active ingredient Plerixafor. It is used in collecting blood stem cells, storage, and transplantation. It is also used in lymphoma (WBC cancer), multiple myeloma (plasma cell cancer in bone marrow), or a solid tumour. Talk to your doctor if you have or had any heart disease. Before starting the treatment, notify your doctor if you have high WBC counts, low platelet counts, or a history of usual lightheadedness or fainting, especially before injection. It is not advised to take this medicine for stem cell mobilisation if you have leukaemia.
Do not take this tablet if you are allergic to Plerixafor or any other medicine ingredients. Notify your doctor if you have kidney disorders; your doctor may adjust the dose of the medicine if you have existing kidney disease. Your doctor may also perform a regular blood test to monitor the blood cell count. Do not take this tablet if you are pregnant or planning to get pregnant, think you might be pregnant, or if you are breastfeeding. It is recommended to use effective contraception. Report to your doctor if you experience any side effects like rashes or swelling around your eyes, a change in breathing (lack of oxygen), or pain in the abdomen (upper left) or left shoulder.
Uses of Rexafor 20mg Injection
Rexafor 20mg Injection is used in the treatment of the following:
- Collect blood stem cells
- Lymphoma and multiple myeloma in adults
- Lymphoma or solid tumours in children (aged between 1 to 18)
Therapeutic Effects of Rexafor 20mg Injection
Rexafor 20mg Injection works by blocking a protein called CXCR4 (chemokine receptor) on stem cells, which helps them move from the bone marrow into the bloodstream. By blocking CXCR4, Rexafor 20mg Injection causes the stem cells to be released into the bloodstream, where the stem cells can be collected and isolated using a machine and stored for transplantation.
Interaction of Rexafor 20mg Injection with other drugs
Inform your healthcare professional about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, and herbal products. Certain medications interact with Rexafor 20mg Injection may reduce effectiveness by causing undesirable side effects.
More Information about Rexafor 20mg Injection
- Keep Rexafor 20mg Injection out of sight and reach of children and pets.
- This tablet does not require any special storage conditions.
- It should be used immediately if the vial is opened.
- Do not refrigerate or freeze.
How to consume Rexafor 20mg Injection
Rexafor 20mg Injection is administered as a subcutaneous injection (under your skin). If this drug is recommended for you, it will be given by a doctor. Do not self-administer. Your doctor will choose the dosage and administration frequency based on the condition because it differs from person to person.
Safety Advice for Rexafor 20mg Injection
Breast Feeding
You must not breastfeed while being treated with Rexafor 20mg Injection. Inform your physician if you are breastfeeding before taking this treatment.
Alcohol
It is not recommended to take alcohol while under this treatment because it may cause drowsiness and sleepiness. Talk to your doctor for more information.
Liver
On the use of Rexafor 20mg Injection in patients with liver illness, there is not much information currently accessible. Please speak with your physician.
Lungs
Consult your doctor immediately if you experience any symptoms like difficulty in breathing. Contact your doctor for more lung-related concerns.
Driving
Rexafor 20mg Injection could affect your ability to drive. Avoid driving while taking this medicine. Talk to your doctor for more information.
Pregnancy
Rexafor 20mg Injection can cause harm to your unborn baby. Report to your doctor if you are pregnant or planning to get pregnant before taking the Rexafor 20mg Injection. Use effective contraception.
Side Effects of Rexafor 20mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious side effects of Rexafor 20mg Injection are:
- Rashes and swelling around the eyes
- Difficulty in breathing
- Faintness
- Upper left abdomen pain
- Left shoulder pain
Common side effects of Rexafor 20mg Injection are:
- Diarrhea
- Redness or irritation in the injection site
- Low RBC count (anaemia)
- Constipation, indigestion
- Dry mouth, numbness
- Joint pains
- Sweating
- Difficulty in sleeping
- Headache
Word of Advice
You need to tell your doctor if you have any kidney disorders before taking Rexafor 20mg Injection. Your physician may decide to adjust the dose or delay treating you depending on your kidney function. Please consult your doctor before starting this injection, and getting suggestions about fertility concerns from your doctor is recommended. Your doctor may take regular blood tests to monitor your liver function and blood cell count.
FAQs about Rexafor 20mg Injection
Q1.
How can I manage the side effects related to Rexafor 20mg Injection use?
Managing side effects of Rexafor 20mg Injection can include taking anti-nausea medication, staying hydrated, and resting. If you experience any side effects, it is important to speak with a healthcare provider. Hence, visit your doctor immediately.
Q2.
Why should I not consume alcohol while taking Rexafor 20mg Injection?
The liver metabolises Rexafor 20mg Injection, and alcohol can also affect liver function. Therefore, consuming alcohol while taking Rexafor 20mg Injection can impact its effectiveness and increase the risk of liver damage. Also, alcohol can increase the risk of certain side effects associated with Rexafor 20mg Injection, such as dizziness, drowsiness, and lightheadedness.
Q3.
How is Rexafor 20mg Injection administered?
Rexafor 20mg Injection is given as a subcutaneous injection (injected under the skin), typically in the stomach or thigh.
Q4.
What if I missed my dose of Rexafor 20mg Injection?
If you missed your regular injection, contact your doctor immediately.
Q5.
How effective is Rexafor 20mg Injection in mobilising stem cells?
Studies have shown that Rexafor 20mg Injection, in combination with G-CSF, is highly effective in mobilising stem cells from the bone marrow into the bloodstream.
Q6.
Who should not take Rexafor 20mg Injection?
Rexafor 20mg Injection is not recommended for patients who have had an allergic reaction to Rexafor 20mg Injection or any of its ingredients. It is also not advised for patients with certain medical conditions, such as severe kidney problems or low white blood cell counts.
Fact Box of Rexafor 20mg Injection
Molecule name: Plerixafor | Therapeutic class: Antineoplastic |
Pharmacological class: Hematopoietic Stem Cell Mobilizers
| Indications: 1. Collect blood stem cells 2. Lymphoma and multiple myeloma in adults 3. Lymphoma or solid tumours in children (aged between 1 to 18) |
References
- Genzyme Corporation, U.S. Food & Drug Administration [Revised on Dec 2017] [Accessed on 13th April 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022311s018lbl.pdf
- Seacross Pharmaceuticals Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 20th April 2023], Plerixafor Seacross 20 mg/ml solution for injection - Patient Information Leaflet (PIL) - (emc) (medicines.org.uk)
- James L. Zehnder, Agents Used in Cytopenias; Hematopoietic Growth Factors, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 591- 607.
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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