Ribaxapi 100mg Tablet may be prescribed for certain patients with:

• Ovarian cancer: Olaparib may be used as maintenance treatment in eligible patients whose cancer has responded to platinum-based chemotherapy. Treatment suitability depends on the cancer type and relevant genetic or molecular findings.

• Breast cancer: Olaparib may be used in certain patients with HER2-negative breast cancer associated with BRCA gene mutations, depending on the stage of cancer and previous treatment.

Not every patient with ovarian or breast cancer is eligible for treatment with Olaparib. Your doctor will assess your condition and relevant test results before prescribing it.

Ribaxapi 100mg Tablet contains Olaparib, which blocks PARP enzymes that help cells repair damaged DNA.

Certain cancer cells have defects in other DNA repair pathways, including those involving BRCA proteins. These cells may depend more heavily on PARP enzymes to repair DNA damage. By blocking this repair pathway, Olaparib allows DNA damage to accumulate in susceptible cancer cells, which can lead to their death and help control cancer growth.

Tell your doctor about all medicines, supplements and herbal products you take before starting Ribaxapi 100mg Tablet. Some products may affect Olaparib levels in the blood and increase the risk of side effects or reduce its effectiveness.

• CYP3A inhibitors: Certain antifungals, antibiotics and antiviral medicines (e.g., itraconazole, clarithromycin and ritonavir) can increase olaparib levels in the blood. Your doctor may adjust your treatment or consider an alternative. 

• CYP3A inducers: Certain medicines, such as rifampicin (antibiotic), carbamazepine and phenytoin (anti-seizure medicines), can reduce olaparib levels in the blood and affect its effectiveness. These combinations should generally be avoided or reviewed by a specialist.

• Other anticancer medicines: Inform your doctor about other cancer treatments you receive, as some combinations may require specific precautions or dose adjustments.

• Grapefruit and grapefruit juice: These may affect Olaparib levels. Ask your doctor whether you should avoid them during treatment.

Do not start, stop or change any medicine without consulting your doctor.

• Store Ribaxapi 100mg Tablet below 30°C, as directed on the product packaging.

• Keep the medicine in its original packaging to protect it from moisture.

• Protect it from excessive heat.

• Keep it out of the reach of children.

Always follow the storage instructions supplied with your specific product.

• Take Ribaxapi 100mg Tablet exactly as prescribed by your doctor.

• The dose and frequency depend on your cancer type, treatment plan, response to treatment, side effects and other medicines you take.

• The 100mg strength may be used when a reduced dose is required. The number of tablets you need depends on your prescribed dose.

• Swallow the tablets whole with water. Do not crush, chew, dissolve or divide them.

• Olaparib tablets may generally be taken with or without food, as directed by your doctor.

• Take your doses at the prescribed times each day.

• If you miss a dose, take your next dose at its usual scheduled time. Do not take an extra dose to make up for the missed one.

Do not change your dose or stop treatment without speaking to your doctor.

Not everyone experiences side effects while taking Ribaxapi 100mg Tablet. The type and severity of side effects can vary between individuals.

Common side effects

Possible side effects of Olaparib include:

• Nausea

• Vomiting

• Diarrhoea

• Tiredness or weakness

• Decreased appetite

• Headache

• Dizziness

• Indigestion

• Anaemia (low red blood cell count)

• Decreased white blood cell or platelet counts

Inform your doctor if these symptoms persist, become severe or interfere with your daily activities. Your doctor may recommend supportive treatment or adjust your dose if necessary.

Serious side effects

Seek prompt medical attention if you experience:

• Unusual bruising or bleeding, persistent fever or recurrent infections, which may indicate low blood cell counts.

• New or worsening breathlessness, cough or fever, which may indicate a lung complication.

• Severe or persistent weakness or tiredness.

• Symptoms that could indicate a blood clot, such as sudden chest pain, difficulty breathing or painful swelling in a limb.

• Persistent abnormalities in blood counts that require further investigation.

Rarely, Olaparib has been associated with serious bone marrow conditions, including myelodysplastic syndrome and acute myeloid leukaemia. Your doctor will monitor your condition and investigate concerning symptoms or abnormal test results.

• Take Ribaxapi 100mg Tablet exactly as prescribed by your doctor.

• Attend scheduled blood tests to monitor your blood cell counts.

• Inform your doctor about all medicines, supplements and herbal products you take.

• Ask your doctor before consuming grapefruit or grapefruit juice during treatment.

• Report persistent fever, unusual bruising, bleeding or signs of infection promptly.

• Seek medical advice if you develop a new or worsening cough or breathlessness.

• Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding.

• Do not crush, chew, dissolve or divide the tablets.

• Do not change your dose or stop treatment without medical advice.