Ribaxapi 150mg Tablet may be prescribed for eligible patients with certain types of cancer, depending on the applicable product authorisation, genetic test results and previous treatment.

• Ovarian cancer: It may be used as maintenance treatment in eligible patients whose cancer has responded to platinum-based chemotherapy.

• Breast cancer: It may be used in certain patients with HER2-negative breast cancer associated with BRCA gene mutations.

• Pancreatic cancer: Olaparib may be used as maintenance treatment for certain patients with BRCA-mutated metastatic pancreatic cancer whose disease has not progressed after platinum-based chemotherapy.

• Prostate cancer: It may be used for certain patients with advanced prostate cancer associated with specific gene changes, depending on the treatment regimen.

Not every patient with these cancers is eligible for olaparib treatment. Your doctor will consider your diagnosis, genetic test results and treatment history before prescribing it.

Ribaxapi 150mg Tablet contains olaparib, which blocks PARP enzymes involved in repairing damaged DNA.

Some cancer cells have changes in DNA repair genes, such as BRCA1 or BRCA2, making it harder for them to repair DNA damage. Blocking PARP adds to this damage, which can cause susceptible cancer cells to die and help control cancer growth.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take before starting Ribaxapi 150mg Tablet.

• CYP3A inhibitors: Certain antifungals, antibiotics and antiviral medicines, such as itraconazole, clarithromycin and ritonavir, can increase olaparib levels in the blood. Your doctor may need to adjust your treatment or consider an alternative.

• CYP3A inducers: Medicines such as rifampicin, carbamazepine and phenytoin can reduce olaparib levels and affect its effectiveness. These combinations should generally be avoided or reviewed by a specialist.

• Other anticancer medicines: Tell your doctor about other cancer treatments you receive, as certain combinations may require specific precautions or dose adjustments.

• Grapefruit and grapefruit juice: These may increase olaparib exposure. Ask your doctor whether you should avoid them during treatment.

Do not start, stop or change any medicine without consulting your doctor.

• Store Ribaxapi 150mg Tablet according to the instructions on its packaging.

• Keep the tablets in their original packaging and protect them from excessive heat and moisture.

• Keep the medicine out of the sight and reach of children.

Check the product packaging for the specific storage temperature recommended for Ribaxapi.

• Take Ribaxapi 150mg Tablet exactly as prescribed by your doctor.

• The dose depends on your cancer type, treatment regimen, response to treatment, side effects and other medicines you take.

• In certain approved treatment settings, the usual olaparib tablet dose is 300mg twice daily. This may involve taking two 150mg tablets per dose, but the appropriate dose for you may differ.

• Swallow the tablets whole with water. Do not crush, chew or divide them.

• Olaparib tablets may generally be taken with or without food.

• Take your doses at the prescribed times each day.

• If you miss a dose, take your next dose at its usual scheduled time. Do not take an extra dose to make up for the missed one.

Do not change your dose or stop treatment without speaking to your doctor.

Not everyone experiences side effects while taking Ribaxapi 150mg Tablet. The type and severity of side effects can vary between individuals.

Common side effects

Possible side effects of olaparib include:

• Nausea

• Vomiting

• Diarrhoea

• Tiredness or weakness

• Decreased appetite

• Headache

• Dizziness

• Indigestion

• Anaemia (low red blood cell count)

• Reduced white blood cell or platelet counts

Inform your doctor if these symptoms persist, become severe or interfere with your daily activities.

Serious side effects

Seek prompt medical attention if you experience:

• Unusual bruising or bleeding, persistent fever or recurrent infections, which may indicate low blood cell counts.

• New or worsening breathlessness, cough or fever, which may indicate inflammation of the lungs.

• Severe or persistent weakness or tiredness.

• Symptoms that may indicate a blood clot, such as sudden chest pain, difficulty breathing or painful swelling in a limb.

Rarely, olaparib has been associated with serious bone marrow conditions, including myelodysplastic syndrome and acute myeloid leukaemia. Your doctor will monitor your blood counts and investigate concerning symptoms or abnormal results.

• Take Ribaxapi 150mg Tablet exactly as prescribed; do not adjust the number of tablets yourself.

• Attend scheduled blood tests to monitor your blood cell counts.

• Tell your doctor about all medicines, supplements and herbal products you take.

• Ask your doctor before consuming grapefruit or grapefruit juice during treatment.

• Report persistent fever, unusual bruising, bleeding or signs of infection promptly.

• Seek medical advice if you develop a new or worsening cough or breathlessness.

• Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding.

• Swallow the tablets whole and follow the storage instructions on the packaging.

• Do not stop treatment or change your dose without medical advice.