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Samylieva 400mg Tablet
Last updated on 13 May 2026 | 08:46 AM (IST)
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Introduction to Samylieva 400mg Tablet
The Samylieva 400mg Tablet contains an active component called the Ademetionine. It can be used to treat intrahepatic cholestasis, a condition in which bile flow from the liver is reduced. It can also be used to treat other types of liver disease, such as cirrhosis and alcoholic hepatitis. It is effective in treating major depressive disorder. This medication helps to promote the production of bile, which is a fluid that helps to digest fats and remove toxins from the body. It can also be used to treat osteoarthritis pain and inflammation. It works by reducing the production of inflammatory chemicals and promoting cartilage repair.
If you are allergic to Samylieva 400mg Tablet or any other ingredient in the medication, you should not take it. This medication may trigger manic episodes in people with bipolar disorder, so it is not recommended for this population. It has not been studied extensively in pregnant or breastfeeding women, so it is best to avoid it during these times. It may be harmful to people with severe kidney function impairment. It should not be used in people with Parkinson's disease, as it may worsen the symptoms. It should be avoided in cases of homocystinuria as it may worsen its symptoms. It is generally safe for older adults. However, it is important to consult a healthcare provider before using it in old age. Ademetionine has not been studied extensively in children, so it is best to avoid it in this population unless specifically recommended by a doctor.
Uses of Samylieva 400mg Tablet
Samylieva 400mg Tablet is used in the following:
- Hepatoprotective
- Antidepressant
- Chondroprotective
- Antioxidant
- Nootropic
Therapeutic Effects of Samylieva 400mg Tablet
Samylieva 400mg Tablet works by donating methyl groups to other molecules, which is essential for many cellular functions, including DNA repair, gene expression, and protein synthesis. It is also a precursor to glutathione, a powerful antioxidant that protects cells from damage. Additionally, it is involved in the production of bile, which helps to digest fats and remove toxins from the body.
Interaction of Samylieva 400mg Tablet with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the Samylieva 400mg Tablet, reducing effectiveness by causing undesirable side effects.
More Information about Samylieva 400mg Tablet
- Store at room temperature, between 20°C to 25°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
How to consume Samylieva 400mg Tablet
Samylieva 400mg Tablet administered orally. Do not break or chew or crush this tablet. Follow the procedure mentioned by the doctor or pharmacist.
Safety Advice for Samylieva 400mg Tablet
Breast Feeding
It is important to consult with a healthcare provider before taking Samylieva 400mg Tablet as it has not been studied extensively in breastfeeding women.
Alcohol
It is not safe alcohol while taking Samylieva 400mg Tablet, as alcohol can exacerbate certain side effects
Liver
If you have liver disorders, informing your healthcare provider before starting the Samylieva 400mg Tablet is important.
Lungs
Consult your healthcare provider if you have a history of lung conditions before using the Samylieva 400mg Tablet.
Driving
Samylieva 400mg Tablet is not known to impair cognitive or motor function. Therefore, it does not typically interfere with the ability to drive or operate machinery. If you experience these symptoms, consult your healthcare provider if you experience side effects.
Pregnancy
Samylieva 400mg Tablet has not been studied extensively in pregnant women, so it is best to avoid it during these times.It is important to consult with a healthcare provider to assess the individual situation.
Side Effects of Samylieva 400mg Tablet
Samylieva 400mg Tablet causes some side effects like all medications, although not everyone will experience them.
Serious
- Allergic reactions
- Mania or hypomania
- Serotonin syndrome
- Worsening liver disease
Common
- Abdominal discomfort
- Nausea and vomiting
- Headache
- Dizziness
- Insomnia
- Anxiety
Word of Advice
Consult a healthcare provider before using Samylieva 400mg Tablet if you have bipolar disorder, Parkinson's disease, or a history of mania. Avoid this medication during pregnancy and breastfeeding, as its safety in these situations is uncertain. Be cautious if you have underlying medical conditions, especially anxiety disorders or diabetes. Children should not use it without a healthcare provider's supervision. Be aware of potential side effects such as gastrointestinal issues, dry mouth, headache, and mild insomnia. Stick to the recommended dosage to avoid adverse effects. Discontinue it at least two weeks before any scheduled surgery, as it might affect the central nervous system. If you have a bleeding disorder or are taking medications that increase bleeding risk, consult a healthcare provider before using this medication.
FAQs about Samylieva 400mg Tablet
Q1.
Are there any dietary restrictions to consider when taking Samylieva 400mg Tablet?
While there are no specific dietary restrictions while taking Samylieva 400mg Tablet, it is advisable to follow a balanced diet as recommended by a healthcare provider.
Q2.
What are the potential side effects of Samylieva 400mg Tablet?
Some common side effects of Samylieva 400mg Tablet may include gastrointestinal disturbances, dry mouth, headache, and mild insomnia. However, individual reactions may vary.
Q3.
Can Samylieva 400mg Tablet be used long-term?
The long-term use of Samylieva 400mg Tablet should be monitored by a healthcare provider, especially if it is used to manage chronic conditions. Regular check-ups and discussions with a healthcare provider can help assess the ongoing benefits and any potential risks associated with long-term use.
Fact Box of Samylieva 400mg Tablet
Molecule name: Ademetionine | Therapeutic class: hepatoprotective agents |
Pharmacological class: Sulfur-containing amino acid derivative. | Indications: 1. Hepatoprotective 2. Antidepressant 3. Chondroprotective 4. Antioxidant 5. Nootropic |
References
Abbott Laboratories, [Accessed on 25th Oct 2023], https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/productpdf/Transmetil%20500mg.pdf
Mazen Noureddin et al., Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review;[Published on Feb 2020][Accessed on 25th Oct 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061266/
S-adenosylmethionine; [Accessed on 25th Oct 2023]; http://accurateclinic.com/wp-content/uploads/2016/02/S-adenosylmethionine-University-of-Maryland-Medical-Center. pdf#2
Disclaimer
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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 13 May 2026 | 08:46 AM (IST)
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