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Sigrima 420mg Injection
Prescription Required
Salt Composition : Pertuzumab
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
1 Vial(s) Of 14ml
Introduction to Sigrima 420mg Injection
Sigrima 420mg Injection, is a targeted therapy containing the active constituents pertuzumab and trasrtuzumab. It is used to treat a type of breast cancer (human epidermal growth factor receptor 2 positive breast cancer) that has spread to other parts of the body (metastasized) or cancer that has come back after the treatment. It will also be given before or after the surgery if the cancer has not metastasized. Cancer occurs when cells begin to grow abnormally in an uncontrolled manner.
Before taking Sigrima 420mg Injection, talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. This medication is not recommended for adolescents and children under 18. In patients with early-stage HER2-positive breast cancer, adding pertuzumab or trastuzumab to standard chemotherapy can reduce the risk of recurrence and improve disease-free survival.
Uses of Sigrima 420mg Injection
- Breast cancer
- Non-small cell lung cancer
Therapeutic Effects of Sigrima 420mg Injection
Human epidermal growth factor receptor 2 protein is largely present in some cancer cells and stimulates the growth of cancer cells. Sigrima 420mg Injection binds selectively to the HER2 receptors on breast cancer cells' surface, blocks them from receiving growth signals, and stops the cancer cells' growth.
Interaction of Sigrima 420mg Injection with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Sigrima 420mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Sigrima 420mg Injection
- Store in a refrigerator between 2°C and 8°C (36°F and 46°F).
- It should not be frozen.
- Keep it in its original packaging until it is ready to be used.
- Keep out of the reach of children and pets.
How to consume Sigrima 420mg Injection
Sigrima 420mg Injection is a medication administered intravenously (IV) by a healthcare professional. It is important to follow the healthcare provider's instructions regarding the dosage and administration of medication. Do not double the dose to make up for missed doses.
Safety Advices for Sigrima 420mg Injection
Pregnancy
Sigrima 420mg Injection may harm the developing fetus, so it is unsafe to use it during pregnancy
Breast Feeding
It is unknown whether Sigrima 420mg Injection is excreted in human milk. So breastfeeding women should consult their doctor before taking it.
Lungs
Sigrima 420mg Injection can cause side effects, and the safety of their use in the lungs depends on several factors. Patients should consult their doctor if they have any pre-existing health condition before taking this medication
Liver
Patients with pre-existing liver disease or impaired liver function may be at increased risk for the potential side effects of Sigrima 420mg Injection, including liver toxicity. So patients should discuss it with their healthcare provider before taking it.
Alcohol
Alcohol use can negatively affect the immune system, and patients receiving Sigrima 420mg Injection may already have compromised immune systems due to their medical condition or treatment. Therefore, it is generally recommended that patients limit their alcohol consumption or avoid alcohol entirely while receiving it.
Driving
Patients should always monitor their response to the Sigrima 420mg Injection medication and be cautious when driving or operating machinery if they experience any side effects that may impair their ability to do so safely.
Side Effects of Sigrima 420mg Injection
Like all medications, Sigrima 420mg Injections cause some side effects, although not everyone will experience them.
Serious:
- Pulmonary toxicity (interstitial lung disease or pneumonitis)
- Infusion-related reactions
- Hypersensitivity reactions
- Liver toxicity
- Immune system effects
- Severe allergic reactions
- Gastrointestinal perforation (rare)
- Reduced blood platelets or white blood cell counts
Common:
- Nausea and vomiting
- Diarrhea
- Fatigue
- Hair loss
- Rash or itching
- Muscle pain or weakness
- Headache
- Difficulty sleeping
- Loss of appetite
Word of Advice
If you are prescribed Sigrima 420mg Injection, or any other medication, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients should be monitored for signs of an allergic reaction, such as rash, itching, or swelling, and should seek immediate medical attention if these symptoms occur. It should be used with caution in patients with severe renal impairment. Talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. Use effective birth control during the treatment and at least seven months after the last dose. Always maintain a healthy and balanced diet to support your overall health and well-being.
FAQs
Q 1. Can Sigrima 420mg Injection cause infertility?
Sigrima 420mg Injection can affect fertility in some patients, although the extent of this effect is not well-understood. Women who wish to preserve their fertility should discuss their options with their healthcare provider before starting treatment with these drugs.
Q 2. Can Sigrima 420mg Injection be used together with chemotherapy?
Yes, Sigrima 420mg Injection are often combined with chemotherapy to treat HER2-positive breast cancer. This combination therapy effectively reduces the risk of recurrence and improves overall survival in patients with HER2-positive breast cancer.
Q 3. Can I take Sigrima 420mg Injection if I have TB?
If you have active tuberculosis (TB) infection, Sigrima 420mg Injection should not be used until the TB infection has been treated and is under control. These drugs can suppress the immune system, worsening TB or other infections.
Fact Box of Sigrima 420mg Injection
Molecule name: PERTUZUMAB | Therapeutic class: Anticancer |
Pharmacological class: Monoclonal antibodies | Indications: Non-small cell lung cancer Breast cancer
|
References
- Roche products limited, Electronic medicines compendium (EMC), [Revised on Jan 2022] [ Accessed on 03/05/2023], https://www.medicines.org.uk/emc/files/pil.11989.pdf
- zhu Chenjing et al.; Safety and efficacy evaluation of pertuzumab in patients with solid tumors; Medicine; [Published on May 2017]; [Accessed on 03/05/2023] https://journals.lww.com/md-journal/fulltext/2017/05190/safety_and_efficacy_evaluation_of_pertuzumab_in.19.aspx
- Sandra M Swain et al; Sigrima 420mg Injection, and docetaxel in HER2-positive metastatic breast cancer; The New England Journal of Medicine; [Published on Feb 2015]; [Accessed on 03/05/203]; https://pubmed.ncbi.nlm.nih.gov/25693012/
Disclaimer
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