Sigrima 420mg Injection, is a targeted therapy containing the active constituents pertuzumab and trasrtuzumab. It is used to treat a type of breast cancer (human epidermal growth factor receptor 2 positive breast cancer) that has spread to other parts of the body (metastasized) or cancer that has come back after the treatment. It will also be given before or after the surgery if the cancer has not metastasized. Cancer occurs when cells begin to grow abnormally in an uncontrolled manner.

Before taking Sigrima 420mg Injection, talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. This medication is not recommended for adolescents and children under 18. In patients with early-stage HER2-positive breast cancer, adding pertuzumab or trastuzumab to standard chemotherapy can reduce the risk of recurrence and improve disease-free survival.

• Breast cancer
• Non-small cell lung cancer

Human epidermal growth factor receptor 2 protein is largely present in some cancer cells and stimulates the growth of cancer cells. Sigrima 420mg Injection binds selectively to the HER2 receptors on breast cancer cells' surface, blocks them from receiving growth signals, and stops the cancer cells' growth.

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Sigrima 420mg Injection and reduce effectiveness by causing undesirable side effects.

• Store in a refrigerator between 2°C and 8°C (36°F and 46°F).
• It should not be frozen.
• Keep it in its original packaging until it is ready to be used.
• Keep out of the reach of children and pets.

Sigrima 420mg Injection is a medication administered intravenously (IV) by a healthcare professional. It is important to follow the healthcare provider's instructions regarding the dosage and administration of medication. Do not double the dose to make up for missed doses.

Like all medications, Sigrima 420mg Injections cause some side effects, although not everyone will experience them. 

Serious:

• Pulmonary toxicity (interstitial lung disease or pneumonitis)
• Infusion-related reactions
• Hypersensitivity reactions
• Liver toxicity
• Immune system effects
• Severe allergic reactions
• Gastrointestinal perforation (rare)
• Reduced blood platelets or white blood cell counts

Common:

• Nausea and vomiting
• Diarrhea
• Fatigue
• Hair loss
• Rash or itching
• Muscle pain or weakness
• Headache
• Difficulty sleeping
• Loss of appetite

If you are prescribed Sigrima 420mg Injection, or any other medication, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients should be monitored for signs of an allergic reaction, such as rash, itching, or swelling, and should seek immediate medical attention if these symptoms occur. It should be used with caution in patients with severe renal impairment. Talk to the physician if you have heart problems, have had radiotherapy, or have allergic conditions. Use effective birth control during the treatment and at least seven months after the last dose. Always maintain a healthy and balanced diet to support your overall health and well-being.

1. Roche products limited, Electronic medicines compendium (EMC), [Revised on Jan 2022] [ Accessed on 03/05/2023], https://www.medicines.org.uk/emc/files/pil.11989.pdf
2. zhu Chenjing et al.; Safety and efficacy evaluation of pertuzumab in patients with solid tumors; Medicine; [Published on May 2017]; [Accessed on 03/05/2023] https://journals.lww.com/md-journal/fulltext/2017/05190/safety_and_efficacy_evaluation_of_pertuzumab_in.19.aspx
3. Sandra M Swain et al; Sigrima 420mg Injection, and docetaxel in HER2-positive metastatic breast cancer; The New England Journal of Medicine; [Published on Feb 2015]; [Accessed on 03/05/203]; https://pubmed.ncbi.nlm.nih.gov/25693012/