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SIMULECT 20MG INJECTION
Prescription Required
Salt Composition : Basiliximab
Manufacturer : NOVARTIS INDIA LTD
Origin of Medicine : Switzerland
1 Vial(s) Of 5ml
Introduction to Simulect 20mg Injection
Simulect 20mg injection is a monoclonal antibody with an active ingredient called Basiliximab. It belongs to the medication class known as immunosuppressant. It is used to prevent the rejection of kidney transplants. It is injected within the first 4 to 6 weeks following the transplant. It is used on adults, adolescents, and children. When a transplanted organ is introduced, the body's immune system recognizes it as foreign and attempts to reject it. This medicine works by inhibiting the immune cells responsible for attacking the transplanted organs. After treatment, your doctor may prescribe medicine (Ciclosporin and Corticosteroids) to protect the new kidney.Â
Do not consume Simulect 20mg injection medicine if you are allergic to Basiliximab and its other ingredients and if you are pregnant or breastfeeding. Before starting the treatment, inform your doctor if you had a transplant in the past and failed after a brief period or if you have ever been in the operating room for an unsuccessful transplant. Do not take any vaccine without consulting your doctor. Inform your physician if you are pregnant or planning to get pregnant. Use effective contraception to avoid pregnancy while undergoing therapy and up to 4 months after the last dosage. Do not breastfeed for up to four months after the second dose. Discuss more fertility concerns with your doctor.Â
Uses of Simulect 20mg Injection
- Prevents rejection of kidney transplant
Therapeutic Effects of Simulect 20mg Injection
Simulect 20mg injection is a monoclonal antibody. It targets and inhibits the activation of an interleukin-2 receptor alpha (IL-2Rα) receptor. This action will reduce the activation and proliferation of immune cells, particularly T lymphocytes (T cells), which are involved in organ rejection.
Interaction of Simulect 20mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Simulect 20mg injection and can cause undesirable side effects.Â
More Information about Simulect 20mg Injection
- Keep out of sight and reach of pets and children
- Store in a refrigerator at a temperature around 2°C - 8°C.
How to consume Simulect 20mg Injection
Simulect 20mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advices for Simulect 20mg Injection
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Pregnancy
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Simulect 20mg injection is unsafe during pregnancy as it may harm the unborn baby. Report to your medical professional if you are pregnant or think you may be pregnant, or planning for the pregnancy before starting the treatment. Use effective contraception during and after the last dose for up to four months.Â
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Breast Feeding
 ÂTaking Simulect 20mg injection while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the second dose. Therefore, talk with your doctor to get more information.Â
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Lungs
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It is unknown whether Simulect 20mg injection is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  It is unknown whether Simulect 20mg injection is safe for patients with liver problems. Inform your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking a Simulect 20mg injection tablet is safe. Please speak with your physician.
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Driving
  Simulect 20mg injection does not affect the driving ability.Â
Side Effects of Simulect 20mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe allergic reactions (swelling of face, tongue, or lips, difficulty in breathing, fast heartbeat, dizziness, decreased urine output).
Common
- Constipation
- Nausea
- Diarrhea
- Sudden weight gain
- Overgrowth of normal hair
- Infections
- High blood pressure
- Running nose
Word of Advice
Simulect 20mg injection is given as an injection into the veins by a healthcare provider only. Inform your medical professional if you are above 65 years older because this medicine is not studied in such conditions. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. Your doctor may change your dose or stop the treatment. Your medical professional will inform you if you need any dose adjustments. Children under 35 kg will receive a dose lower than what is typically administered to adults. Contact your doctor for more information.Â
FAQs
Q 1. How can I manage diarrhea while taking Simulect 20mg injection?
If you experience diarrhea while taking Simulect 20mg injection, stay hydrated by drinking plenty of fluids. Your medical professional may also recommend over-the-counter or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.
Q 2. How long should I take Simulect 20mg injection?
Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking Simulect 20mg injection if your doctor advises you to stop.
Q 3. How should Simulect 20mg injection be used?
A well-trained physician or nurse should always inject intravenous injection into the patient. Kindly do not self-administer the Simulect 20mg injection.
Q 4. When should I contact my doctor?
Notify your medical professional if you experience any side effects, especially allergic reactions with swelling of the face, tongue, or lips, difficulty in breathing, fast heartbeat, dizziness, or decreased urine output.
Q 5. Who should not take Simulect 20mg injection?
Notify your medical professional if you are pregnant or breastfeeding because Simulect 20mg injection can harm your baby. Also, use effective contraception.
Fact Box of Simulect 20mg Injection
| Molecule Name: Basiliximab | Therapeutic class: Immunosuppressant |
| Pharmacological class: Monoclonal antibody | Indications: Prevents rejection of kidney transplant |
References
- Novartis Pharmaceuticals UK Limited, Electronic medicines compendium (emc), [Revised on Sept 2021] [ Accessed on 24th May 2023], https://www.medicines.org.uk/emc/files/pil.7834.pdf
- Xuping Yao et al; Basiliximab induction in kidney transplantation with donation after cardiac death donors; Experimental and Therapeutic medicine; [Published on 08/04/2016], [Accessed on 18/12/2021]; https://www.spandidos-publications.com/10.3892/etm.2016.3238
- Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [ Accessed on 24th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/1998/basnov051298lb.pdf
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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