• Advanced renal cell carcinoma
• Advanced hepatocellular carcinoma
• Differentiated  thyroid carcinoma

Sorafeb 200mg Tablet 30's works by inhibiting multiple protein kinases involved in tumour cell proliferation and angiogenesis (the formation of new blood vessels that supply tumours). Specifically, it targets receptors for vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and Raf kinases, which play key roles in cancer development and progression.  This stops the growth and spread of the tumour cells to other organs, as well as the formation of blood vessels in the tumour cells.

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Sorafeb 200mg Tablet 30's and reduce its effectiveness by causing undesirable side effects.

• Store Sorafeb 200mg Tablet 30's in the original package at room temperature (20°C to 25°C).
• Keep it out of reach of children.

The medicine will be prescribed to you by a healthcare professional in a hospital setting. It is not recommended to take this medication with meals that are high in fat since this may reduce Sorafeb 200mg Tablet 30's's effectiveness. Take the pills at least one hour before or two hours after a high-fat meal if you plan to eat one. The dose will be decided by your healthcare professional based on your condition. Avoid crushing, opening, or dissolving the tablet and swallow it whole with a glass of water. Take the Sorafeb 200mg Tablet 30's at the same time every day.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• gastrointestinal perforation
• abnormal heart rhythm (QT prolongation)
• Inflammation of the liver
• breathing or swallowing difficulties
• Stevens-Johnson Syndrome and toxic epidermal necrolysis
• Decreased blood flow to the heart
• Increased risk of bleeding (blood in urine, stool, vomit, cough)

 Common:

• Nausea
• Vomiting
• Fatigue
• Diarrhoea
• Alopecia
• Hand-foot skin reaction
• Gut wall bleeding

Follow all instructions and dosing recommendations provided by your healthcare provider. Do not take more or less of the medication than prescribed. Report any new or worsening symptoms to your healthcare provider immediately, especially if they relate to your lungs, eyes, skin, liver, kidneys, heart, or bleeding. When undergoing this therapy, stay out of direct sunlight and wear sunscreen with an SPF of at least 50 before going outside. Sorafeb 200mg Tablet 30's should not be stopped without first talking to your doctor. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping Sorafeb 200mg Tablets 30's. It is recommended to inform your doctor about other anticancer drugs you have been taking. It's critical to maintain a sufficient fluid intake because dehydration can exacerbate symptoms such as diarrhoea and other gastrointestinal disorders. 

Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately.

1. Bayer (Pty) Ltd, [Revised on 22nd Apr 2016] [Accessed on  15th March 2024], https://www.bayer.com/sites/default/files/NEXAVAR_200_EN_PI.pdf
2. Bayer HealthCare Pharmaceuticals Inc., US Food & Drug Administration, [Revised on Dec 2018] [Accessed on 15th  March 2024]], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021923s020lbl.pdf
3. Bayer AG, European Medicines Compendium (emc), [Revised on April 2023], [Accessed on  15th March 2024], https://www.medicines.org.uk/emc/files/pil.226.pdf
4. Zentiva Pharma UK Limited,  Medicines Compendium (emc), [Revised on April 2022], [Accessed on  15th March 2024] https://www.medicines.org.uk/emc/files/pil.13098.pdf
5. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.