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Taftrio Tablet
Prescription Required
Salt Composition : Bictegravir,emtricitabine,tenofovir Alafenamide
Manufacturer : HETERO HEALTHCARE LTD
Origin of Medicine : India
60 Tablet(s) In A Bottle
Introduction to Taftrio Tablet
Taftrio Tablet is an antiretroviral drug that contains Bictegravir, Emtricitabine, and Tenofovir Alafenamide. It is used in the treatment of HIV-1 infection. It is a Human immunodeficiency virus that mainly occurs when a person's immune system is attacked and weakened by the human immunodeficiency virus (HIV). This infection progressively weakens the immune system, making individuals more susceptible to opportunistic infections.
Do not take this drug if allergic to Taftrio Tablet and other ingredients. During the early stages of HIV-1 treatment, some patients may experience an inflammatory response to opportunistic infections. This condition is called immune reconstitution syndrome. It can occur after starting the drug or other antiretroviral therapies. Knowing this possibility and monitoring for any signs of worsening infections or inflammatory symptoms is necessary. Report to your doctor if you have had a history of heart failure, pancreatitis, bone disease, fractures, liver or kidney problems. Patients diagnosed with pancreatitis or at risk of pancreatitis should take this combination of medicine cautiously. During the treatment, your doctor may periodically monitor your blood counts, bone mineral density, and liver and kidney parameters to prevent serious complications.
Adults of childbearing potential should consider using an effective contraceptive to prevent an unwanted pregnancy. If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment, as this combination regimen is not recommended during early pregnancy. Breastfeeding is not recommended due to the possible transmission of HIV-1 infection from the mother to the baby. It's necessary to inform your doctor about all your medications, including prescription, over-the-counter, and herbal supplements, to ensure no potential interactions.
Uses of Taftrio Tablet
- Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection
Therapeutic Effects of Taftrio Tablet
Taftrio Tablet combines integrase strand transfer inhibitors and nucleoside, nucleotide analogue reverse transcriptase inhibitors. It increases the number of CD4 T cells and stimulates the immune system to fight against infections. Thereby, it reduces the viral load of HIV in the blood and decreases the severity of HIV infection.
Interaction of Taftrio Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Taftrio Tablet and can cause undesirable side effects.
More Information about Taftrio Tablet
- Store Taftrio Tablet at room temperature below 30°C.
- Keep out of sight and reach of pets and children.
How to consume Taftrio Tablet
Take the Taftrio Tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.
Safety Advices for Taftrio Tablet
Pregnancy
Consult your physician if you are pregnant or planning for pregnancy during the treatment with Taftrio Tablet.
Breast Feeding
Breastfeeding is not recommended in individuals taking a Taftrio Tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Lungs
Whether Taftrio Tablet is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Liver
Taftrio Tablets should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.
Alcohol
It is unsafe to consume alcohol while taking a Taftrio Tablet. It may reduce the drug's effectiveness and can cause toxic side effects.
Driving
Taftrio Tablets can make you feel dizzy and affect your concentration. Do not drive or operate machinery.
Side Effects of Taftrio Tablet
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Serious
- Bone loss
- Worsening of Hepatitis B
- Kidney injury
- Immune reconstitution syndrome
- Lactic acidosis
- Liver toxicity
Common
- Depression
- Abnormal dreams
- Headache
- Dizziness
- Diarrhea
- Feeling sick (Nausea)
- Tiredness (Fatigue)
Word of Advice
To prevent the spread of HIV-1 infection, avoid sharing needles or syringes, which can transmit HIV-1 infections easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items like toothbrushes, razor blades, or anything with body fluids or blood should also be avoided. They should not be shared because HIV-1 can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus. Do not have any sex without protection. It is necessary to practice safe sex using a polyurethane condom or latex to lower the risk of sexual contact with semen, vaginal secretions, or blood.
If you remember to take a Taftrio Tablet for the entire day, take your usual dose the next day. However, do not double-dose yourself. Do not store this tablet in a moist place like a bathroom cabinet or near the kitchen sink. Keep your tablet in a tightly closed container. Do not accept if the seal over the bottle opening is broken or missing. This medicine was prescribed for your specific condition. Please do not use it for other conditions. Do not give this tablet to others, even if they have the same symptoms like you have. It may harm them.
FAQs
Q 1. What should you not take with a Taftrio Tablet?
Taking Taftrio Tablet with antacids is not recommended. Tell your healthcare provider about taking other medications, over-the-counter drugs, vitamins, or herbal supplements.
Q 2. How do I take a Taftrio Tablet if I have difficulty swallowing?
If you have problems swallowing Taftrio Tablet, split the tablet into two and take them separately within 10 minutes.
Q 3. How to store a Taftrio Tablet?
Store Taftrio Tablet at room temperature in a tightly closed container away from the reach of children.
Q 4. What are the required laboratory parameters before starting this treatment with Taftrio Tablet?
If you are an adolescent or adult of childbearing potential, your healthcare provider will perform a pregnancy test before prescribing Taftrio Tablet. Other prominent tests for HBV infection are serum creatinine, estimated creatinine clearance, urine glucose, and urine protein.
Q 5. What should you do if you miss a dose of Taftrio Tablet?
If you missed a dose of Taftrio Tablet, take one tablet when you remember. Anyhow, if it is almost time for your next dose, skip this dose and take your next dose as per schedule. Do not double the dose to compensate for the missed dose.
Q 6. What are some of the long-term side effects of the Taftrio Tablet combination regimen?
Some serious side effects of Taftrio Tablet combination regimen include worsening hepatitis B, bone loss, kidney injury, pancreatitis, immune reconstitution syndrome, liver toxicity, and hypersensitivity reactions.
Fact Box of Taftrio Tablet
Molecule name: Bictegravir, Emtricitabine, Tenofovir Alafenamide
| Therapeutic class: Antiretroviral |
Pharmacological class: 1. Bictegravir-Integrase strand transfer inhibitor (INSTI) 2.Emtricitabine-Nucleoside reverse transcriptase inhibitor (NRTI) 3.Tenofovir Alafenamide-Nucleotide reverse transcriptase inhibitor (NtRTI) | Indication: Treatment of human immunodeficiency virus 1 (HIV-1) infection |
References
- Gilead Sciences Inc., U.S. Food and Drug Administration (EMC), [Revised on Oct 2021] [Accessed on 20th May 2023], https://www.medicines.org.uk/emc/files/pil.9313.pdf
- KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th Edition, 2011, 1634-1638.
Disclaimer
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