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Both men and women taking Temonat 20mg Capsule should use effective birth control.
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Women of reproductive potential must use contraception during treatment and for six months after therapy.
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Men receiving Temonat 20mg Capsule should avoid fathering children and use reliable contraception during treatment and for three months after therapy.
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Doctors may recommend routine blood tests to monitor:
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Electrolyte levels
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Blood cell count
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Liver function.
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Quick Summary
Temonat 20mg Capsule
Written By:Dr. Bhairavi SPharm. D Reviewed By:Dr. Tejashwin AdigaMBBS
Last updated on 26 Sep 2026 | 08:44 AM (IST)
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Introduction
Temonat 20mg Capsule contains the active ingredient temozolomide, which belongs to the class of antitumor agents. It is prescribed for the treatment of brain cancers such as glioblastoma multiforme in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma, in patients older than three years. These are some of the most aggressive forms of brain tumors with low survival chances. Temonat capsule for glioblastoma treatment is commonly recommended, where anaplastic astrocytoma may be treated with Temonat alone or along with radiotherapy after biopsy, while glioblastoma multiforme is treated using a combination of radiotherapy and Temonat, followed by maintenance therapy.
The Temonat 20mg composition includes temozolomide as the active component. This oral alkylating agent works by slowing down or stopping the growth of cancer cells, making it a critical part of treatment protocols.
When it comes to Temonat 20mg dosage and how to take, the amount depends on the patient’s age, body weight, type of tumor, and overall health condition. It is usually taken once daily as prescribed by the oncologist, and the capsules should be swallowed whole with water without breaking or chewing. Dose adjustments may be necessary depending on blood test results and tolerance levels.
Temonat is also used in pediatric cases, and Temonat 20mg for brain tumor in children is considered effective for those above three years of age with certain types of malignant glioma. However, it should only be given under strict medical supervision.
Like any chemotherapy drug, it has Temonat 20mg side effects and risks. Some of the common side effects include nausea, vomiting, loss of appetite, fatigue, headache, constipation, and hair loss. In some cases, serious complications may occur, such as low blood cell counts, abnormal liver function, or increased susceptibility to infections. Routine monitoring with blood tests is essential to manage these risks effectively.
For patients who may not tolerate it well or where availability is an issue, doctors may recommend a Temonat 20mg substitute, which usually contains the same active ingredient, temozolomide, under a different brand name. However, switching should only be done after consulting the treating oncologist.
Finally, Temonat 20mg Natco Pharma is manufactured by Natco Pharma, a reputed pharmaceutical company known for its oncology and specialty medicines. Its reliability and quality make it a widely used choice in cancer treatment across the world.
Uses
Temonat 20mg uses are
- Treatment of newly diagnosed glioblastoma multiforme.
- Treatment of refractory anaplastic astrocytoma
How Temonat 20mg Capsule works
Temonat 20mg Capsule acts by inhibiting the production of genetic material (DNA and RNA) of the cancer cells, which results in preventing their cell growth and multiplication, thereby preventing cancer spread to other parts of the body.
Interaction of Temonat 20mg Capsule with other drugs
Inform your doctor about any medicines you take or have taken before the treatment.
Storage conditions
- Keep Temonat 20mg Capsule out of sight and reach of children.
- Store protected from light and moisture.
- Do not store above 25°C.
How to take Temonat 20mg Capsule
Use as directed by your physician. Your physician will prescribe an adequate dose according to your height and weight. Swallow the capsule whole with a glass of water, on an empty stomach. Do not open, crush or chew the capsule and avoid contact of the open capsules with your skin.
Safety Advice for Temonat 20mg Capsule
Breast Feeding
Unsafe
Temonat 20mg Capsule is unsafe to use during breastfeeding as it passes through breast milk and harm the baby. Consult your physician for advice before breastfeeding.
Alcohol
Consult Your Doctor
Avoid consuming alcohol while taking Temonat 20mg Capsule as it may cause unpleasant side effects. Consult our doctor for advice.
Liver
Consult Your Doctor
Inform your physician before taking Temonat 20mg Capsule if you have severe liver problems. Dose adjustment is required based on the condition.
Lungs
Consult Your Doctor
Inform your physician before taking Temonat 20mg Capsule if you have if you have any lung conditions.
Driving
Unsafe
Do not drive or operate heavy machines while being treated with Temonat 20mg Capsule as it may decrease alertness, affect your vision and make you dizzy and sleepy.
Pregnancy
Unsafe
Temonat 20mg Capsule is unsafe to use during pregnancy as it may cause fetal harm. It should not be used unless prescribed by your physician. Women with childbearing potential should use effective contraceptive precautions for at least 6 months following the completion of treatment.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Temonat 20mg side effects are
Serious:
- Secondary cancer like myelodysplastic syndrome and myeloid leukemia.
- Severe Allergic reactions
- Inflammation and fluid buildup in lungs
- Blood clot in lungs or legs
- Liver toxicity
- Convulsions
- Fever and chills
- Severe headache
- Uncontrolled bleeding
Common:
- Hair loss
- Rashes
- Tiredness
- Nausea, vomiting and diarrhea
- Constipation
- High blood sugar levels
- Dizziness, impaired sensation, tingling sensation, abnormal taste
- Vision and Hearing problem
- Frequent urination
- Muscle damage, pain in muscles and joints
- Weight changes
- Infections and wounds
- Amnesia
- Abnormal blood cell counts
- Loss of appetite
- Sleep problems
- Memory loss
- Difficulty concentrating, changes in mental status and alertness
- Coordination problems
Expert Tips
FAQs about Temonat 20mg Capsule
Q1.
What class of medication is Temonat 20mg Capsule?
Temonat 20mg Capsule belongs to the class of medications called Antitumor agents
Q2.
Can children use Temonat 20mg Capsule?
No, Temonat 20mg Capsule is not recommended for usage in children under 3. There is limited information on patients over the age of 3 who have taken this medication. Consult your doctor before taking Temonat 20mg Capsule.
Q3.
What is the best time to take Temonat 20mg Capsule?
It is best to take Temonat 20mg Capsule once a day on an empty stomach. Take the capsule at the same time every day for better results.
Q4.
Can I take vaccinations while taking Temonat 20mg Capsule?
No, The live vaccine may interact with Temonat 20mg Capsule. Hence, without consulting your healthcare provider, this medication should not be taken with any vaccinations.
Q5.
Can I drive while taking Temonat 20mg Capsule?
No, taking Temonat 20mg Capsule while driving and operating heavy machines may cause dizziness, sleepiness, and decreased alertness, affecting your vision.
Fact Box of Temonat 20mg Capsule
|
Molecule name | Temozolomide |
|
Therapeutic class |
Alkylating agents |
|
Pharmacological class |
Antitumor agents |
|
Indications |
1. Treatment of newly diagnosed glioblastoma multiforme. 2. Treatment of refractory anaplastic astrocytoma |
References
1. Sun Pharmaceutical Industries, Electronic Medicines Compendium (EMC) [Revised on Feb 2022] [Accessed on 21 Nov 2022] https://www.medicines.org.uk/emc/files/pil.5318.pdf
2. Pfizer, US Food and Drug Administration, [Revised on Sep 2015] [Accessed on 21 Nov 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021029s031lbl.pdf
3. Neha Singh et al., Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review, Cancer Drug Resist; Published on Mar 2021; Accessed on 21/09/2022; https://cdrjournal.com/article/view/3779
4. Zerong Tian et al., Glioblastoma and Anaplastic Astrocytoma: Differentiation Using MRI Texture Analysis, Front. Oncol., Published on Sep 2019; Accessed on 21/09/2022; https://www.frontiersin.org/articles/10.3389/fonc.2019.00876/full
Disclaimer
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Author Details

Written By
Dr. Bhairavi S
Pharm. D

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:44 AM (IST)

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