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Treoall 5gm Injection
Prescription Required
Salt Composition : Treosulfan
Manufacturer : HETERO HEALTHCARE LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Treoall 5gm Injection
Treoall 5gm injection contains the active substance Treosulfan. It is an anti-neoplastic medication belonging to the group called alkylating agents. This medicine is combined with Fludarabine to treat allogeneic hemopoietic stem cell transplant (alloHSCT) in adults with both malignant and non-malignant. In pediatric patients (older than one month), it treats malignant.
Do not take a Treoall 5gm injection if you are allergic to Treosulfan or its other ingredients. Notify your doctor if you have any infections or disorders with the heart, lungs, liver, or kidney. Before starting the treatment, inform your doctor if you took any live vaccine or have Fanconi anemia (inherited bone marrow failure syndromes) or other DNA breakage repair disorders. This medicine may reduce the blood count (myelosuppression); your doctor will monitor your blood counts and liver enzymes regularly to detect their functions until recovery of the hematopoietic system.
Before taking a Treoall 5gm injection, notify your doctor if you are pregnant or planning to get pregnant or breastfeeding. Use effective contraception during and after the last dose for six months of the treatment. Tresosulfan impacts fertility impairment if advised not to father a child during and up to 6 months after treatment. In pediatric patients, dermatitis diaper (inflammation of the skin in the diaper area) may occur, so napkins should be changed frequently for 6–8 hours. Contact your doctor for more information.
Uses of Treoall 5gm Injection
- Allogeneic hemopoietic stem cell transplant (alloHSCT)
Therapeutic Effects of Treoall 5gm Injection
Treoall 5gm is an alkylating agent. Its mechanism is to cause damage to the DNA structure, leading to inhibition of DNA replication and cancer cell death.
Interaction of Treoall 5gm Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications may interact with the effects of Treoall 5gm and reduce its effectiveness by causing undesirable side effects.
More Information about Treoall 5gm Injection
- Store at 25˚C, excursions permitted to 15˚C to 30˚C.
- Keep away from pets and children.
- Do not refrigerate.
How to consume Treoall 5gm Injection
Treoall 5gm injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advices for Treoall 5gm Injection
Pregnancy
Treoall 5gm is unsafe to use during pregnancy as it may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment.
Breast Feeding
Breastfeeding is not recommended in Treoall 5gm patients because it is unknown whether the medicine passes into the breast milk. So, do not breastfeed during the treatment.
Lungs
Inform your physician about any underlying lung disorders before taking Treoall 5gm, as this medication should be used cautiously in lung disease patients. Consult your physician before taking this medicine.
Liver
Inform your physician about any underlying liver disorders before taking Treoall 5gm, as this medication should be used cautiously in liver disease patients. Consult your physician before taking this medicine.
Alcohol
It is unknown whether consuming alcohol while taking a Treoall 5gm tablet is safe. Please speak with your physician.
Driving
While taking Treoall 5gm, driving or using machines is unsafe because it may cause nausea, changes in vision, vomiting, etc. Talk to your doctor for more information.
Side Effects of Treoall 5gm Injection
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Serious
- Decrease in blood cell count
- Infections
- Liver vien blockage
- Lung inflammation
Common
- Allergic reaction
- Decreased appetite
- Headache, dizziness
- Irregular heartbeat
- Breathing difficulties Joint pain
- Increased liver enzymes
- The lower level of bilirubin
Word of Advice
Men should avoid fathering a child during and up to 6 months after treatment. This medicine is not safe to be used in pregnancy. Consult your doctor for advice. Use effective contraception during and after six months of the last dose. This medicine can cause fertility impairment; consult your doctor for more fertility concerns. Don't splash or spill the medicine anywhere on the skin. In infants under four months, there is a chance of getting a seizure. Hence monitor for nervous disorders and breathing problems.
FAQs
Q 1. How is Treoall 5gm dosage determined?
Treoall 5gm dosage is based on several factors, including the type and stage of the cancer being treated, the individual's overall health, and their response to the treatment.
Q 2. Can Treoall 5gm cause a lower level of bilirubin?
One of the common side effects of Treoall 5gm is the lower level of bilirubin. If you experience any side, contact your physician immediately.
Q 3. Why is liver enzyme getting elevated during treatment with Treoall 5gm?
The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary and typically resolves on its own or with dose adjustment of the Treoall 5gm tablet.
Q 4. What if I missed a dose of Treoall 5gm?
Do not miss your dose. Keep all your appointments with the dosing regularly. If you forget or miss an appointment, inform your healthcare professional and reschedule the dosing.
Q 5. Can I stop taking Treoall 5gm after I feel better?
Even if you feel better, continue taking doxycycline until the prescription is completed. If you stop using Treoall 5gm injections too soon or skip doses, your illness may not be entirely treated.
Fact Box of Treoall 5gm Injection
Molecule name: Treosulfan | Therapeutic class: Antineoplastics |
Pharmacological class: Alkalyting agent | Indications: Allogeneic hemopoietic stem cell transplant (alloHSCT) |
References
- Medexus Inc., [Revised on 25th Jun 2021] [Accessed on 06 May 2023], https://d1io3yog0oux5.cloudfront.net/medexusinc/files/pages/medexusinc/db/795/description/Trecondyv+Product+Monograph.pdf
- Medac, [Accessed on 06 May 2023], https://www.ema.europa.eu/en/documents/product-information/trecondi-epar-product-information_en.pdf
- International Agency for Research on Cancer; Treosulfan; PHARMACEUTICALS; NCBI Bookshelf; [Revised on 2012] [Accessed:06 May 2023]; https://www.ncbi.nlm.nih.gov/books/NBK304322/#_NBK304322_pubdet_
- RA Hilger et al.; Clinical pharmacokinetics of intravenous Treosulfan in patients with advanced solid tumors; [Revised on 1998] [Accessed:06 May 2023] ; https://pubmed.ncbi.nlm.nih.gov/9654108/
- GP Breitbach; Treosulfan in the treatment of advanced ovarian cancer: a randomized co-operative multicentre phase-III study; [Revised on 2002] [Accessed:06 May 2023]; https://pubmed.ncbi.nlm.nih.gov/12530019/
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