Tukavo 150mg Tablet is a medicine used to treat a specific type of breast cancer called HER2-positive breast cancer, especially when it has spread to other parts of the body, including the brain. It is usually given along with two other medicines—trastuzumab and capecitabine.

Tucatinib in Tukavo 150mg Tablet works by blocking a protein (HER2) that helps cancer cells grow. By doing this, Tucatinib helps slow down or stop the cancer from spreading further.

Tucatinib is not a chemotherapy drug. It is a targeted therapy, which means it attacks cancer cells more specifically and causes less harm to healthy cells. It is given only with a doctor’s advice and regular checkups are needed during treatment to make sure the medicine is working safely.

Tukavo 150mg Tablet is used for:

• HER2-positive advanced or metastatic breast cancer

• Brain metastases in HER2+ breast cancer patients

• Use in combination with trastuzumab and capecitabine after previous HER2-directed therapies

This therapy is typically considered when other standard HER2 treatments have become ineffective.

Tukavo 150mg Tablet belongs to a group of medicines known as tyrosine kinase inhibitors (TKIs). It works by:

• Specifically targeting the HER2 receptor, a protein that promotes cancer cell growth

• Blocking HER2-related signaling pathways that drive tumor progression

• Working synergistically with other anticancer drugs like trastuzumab and capecitabine

• Crossing the blood-brain barrier to treat cancer that has spread to the brain

This focused mechanism helps slow disease progression while minimizing impact on normal cells.

Inform your doctor about all medicines, supplements, or herbal products you are taking. Tukavo 150mg Tablet may interact with:

• Azole antifungals (e.g., ketoconazole, itraconazole)

• Macrolide antibiotics (e.g., clarithromycin)

• Rifampin and rifabutin (may reduce Tucatinib levels)

• Anticonvulsants like phenytoin, carbamazepine

• St. John’s Wort (a herbal product that can reduce effectiveness)

• Proton pump inhibitors and other acid-lowering agents

These interactions may either increase toxicity or reduce Tucatinib's effectiveness.

• Store below 30°C in a dry place, away from direct sunlight.

• Keep in the original blister or bottle until ready to use.

• Do not freeze or expose to moisture.

• Keep out of reach of children and pets.

• Safely discard expired or unused capsules—do not flush them.

• Take Tukavo 150mg Tablet by mouth, exactly as prescribed by your oncologist.

• Usually taken twice a day (every 12 hours), with or without food.

• Swallow capsules whole with water. Do not crush, chew, or open them.

• Take at the same time every day to maintain steady drug levels.

• If vomiting occurs after taking a dose, do not retake it. Wait for the next scheduled dose.

• Do not miss doses, and do not stop without consulting your doctor.

Common Side Effects

Some people may have:

• Loose motion (diarrhea)

• Feeling very tired

• Nausea or vomiting

• Mouth sores

• Less hunger

• Red or sore hands and feet

• Liver test changes (seen in blood reports)

These usually go away with time or treatment. Tell your doctor if any feel too strong or last long.

Serious Side Effects (Call Your Doctor Right Away)

• Yellow skin or eyes (could mean a liver problem)

• Bad diarrhea with weakness

• Trouble breathing or swelling (could be an allergy)

• High fever or infections

Report any unexpected or persistent side effects to your doctor immediately.

• Keep oral rehydration salts (ORS) handy in case of diarrhea.

• Use sunscreen and moisturizers to prevent skin reactions on hands and feet.

• Stick to a mild diet if experiencing nausea; avoid spicy or greasy foods.

• Inform your healthcare provider if you’re taking any over-the-counter meds.

• Track side effects daily using a treatment journal—it helps your doctor manage symptoms early.