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Valentax 100mg Tablet
Last updated on 19 Aug 2026 | 06:50 AM (IST)
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Introduction
Valentax 100 mg Tablet contains the active ingredient Venetoclax. Valentax 100 mg Tablet is an antineoplastic drug in the class of BCL-2 inhibitors. It is used to treat adults with certain types of blood cancers, including chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML).
Specifically, it is used in CLL with a 17p deletion and in AML in patients who cannot undergo intensive chemotherapy. It can also be used in combination with other medications to treat certain types of non-Hodgkin lymphoma.
Valentax 100 mg Tablet works by inhibiting the BCL-2 protein, which helps promote cancer cell death. This action restores apoptosis (programmed cell death) by binding to BCL-2, displacing pro-apoptotic proteins, and initiating mitochondrial outer membrane permeabilisation, which triggers cell death.
Do not take Valentax 100 mg Tablet if you are allergic to Venetoclax or any of the other ingredients in the medication. Before starting treatment, inform your doctor if you have kidney problems, a history of infections, or any blood-related disorders, such as low white blood cell count or low platelet count.
Ensure that your physician is aware of any past history of Tumour Lysis Syndrome (TLS) or if you are pregnant or planning to become pregnant, as Venclexta may harm the fetus. Valentax 100 mg Tablet should not be used in children or adolescents under the age of 18.
Uses
Valentax 100 mg Tablet is used in the treatment of the following:
Chronic lymphocytic leukaemia (CLL), including CLL with 17p deletion
Acute myeloid leukaemia (AML) in adults who cannot undergo intensive chemotherapy
Certain types of non-Hodgkin lymphoma, when combined with other medications
How Valentax 100 mg Tablet works
Valentax 100 mg Tablet works as a selective, orally bioavailable small-molecule inhibitor of BCL-2, an antiapoptotic protein. In CLL and AML cells, BCL-2 overexpression supports tumour cell survival and chemotherapy resistance by binding directly to BCL-2. Valentax 100 mg Tablet displaces pro-apoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilisation and activating caspases. Nonclinical studies demonstrate venetoclax’s cytotoxic effect on tumour cells overexpressing BCL-2.
Interaction of Valentax 100 mg with other drugs
Inform your healthcare professional about all medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Valentax 100 mg Tablet, potentially affecting its effectiveness or causing side effects.
Storage Conditions
Keep out of reach of children and pets.
Store Valentax 100 mg Tablet in the original packaging to protect from moisture.
Avoid direct sunlight
Store Valentax 100 mg Tablet at a temperature not exceeding 30°C.
How To Use
Valentax 100 mg Tablet is administered orally. Do not break, chew, or crush the tablets. Follow the prescribed dosing schedule and consult your healthcare provider to determine the correct dosage. If you miss a dose, do not double the dose. Contact your healthcare provider for guidance.
Safety Advice
Pregnancy
It is unsafe to consume Valentax 100 mg Tablet during pregnancy, as it may cause harm to the fetus when administered to pregnant women.
Breast Feeding
It is unknown whether Valentax 100 mg tablets are safe to take during breastfeeding. Please consult your healthcare provider if you have any concerns.
Lungs
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Valentax 100 mg Tablet.
Liver
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Valentax 100 mg Tablet.
Alcohol
It is unknown whether alcohol consumption is safe while you are undergoing a Valentax 100 mg Tablet course. Consult your doctor for guidance.
Driving
Valentax 100 mg Tablet has no or negligible effect on your ability to drive or operate machines, so it is generally safe to use.
Side Effects
Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.
Common side effects of Valentax 100 mg Tablet are
Fatigue
Anemia
Nausea
Diarrhea
Low platelet count (thrombocytopenia)
Low white blood cell count (neutropenia)
Serious side effects of Valentax 100 mg Tablet are:
Risk of death
Tumour lysis syndrome (TLS)
Kidney failure
Need for dialysis treatment
Expert Tips
Valentax 100 mg Tablet can cause serious side effects like Tumour Lysis Syndrome (TLS), neutropenia, and infections, requiring close monitoring and prophylactic treatment, especially during the ramp-up phase. It may also harm the fetus, so women of reproductive potential should avoid pregnancy during treatment. Regular blood counts are essential to detect neutropenia, and you should avoid live attenuated vaccines. Follow your healthcare provider’s instructions carefully, stay hydrated, and notify your doctor immediately if you experience symptoms like fever or unusual tiredness.
FAQs
Q1.
What is the new cancer drug Valentax 100 mg Tablet?
Valentax 100 mg Tablet is a cancer drug used to treat certain blood cancers, including chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML). It works by inhibiting the BCL-2 protein, which helps cancer cells survive, thereby promoting their death.
Q2.
What type of chemo is Valentax 100 mg Tablet?
Valentax 100 mg Tablet is not a traditional chemotherapy drug. It is a targeted therapy that inhibits the BCL-2 protein to promote cancer cell death.
Q3.
How successful is Valentax 100 mg Tablet?
Valentax 100 mg Tablet has shown significant success in treating chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML), especially in patients with high-risk forms of these cancers. Clinical studies demonstrate improved survival rates and remission in many patients
Q4.
Does Valentax 100 mg Tablet lower platelets?
Yes, Valentax 100 mg Tablet can lower platelet counts, leading to thrombocytopenia in some patients. Regular blood tests are needed to monitor platelet levels during treatment
Q5.
Does Valentax 100 mg Tablet cause side effects?
Yes, Valentax 100 mg Tablet can cause side effects. Common ones include nausea, diarrhoea, fatigue, and low blood cell counts. It can also lead to more serious effects, such as tumour lysis syndrome (TLS) and infections. Regular monitoring by a healthcare provider is essential to manage and prevent complications.
Fact Box
Molecule name | Venetoclax |
Therapeutic class | Antineoplastic agent |
Pharmacological class | BCL-2 inhibitor |
Indications | 1. Chronic lymphocytic leukaemia (CLL), including CLL with 17p deletion 2. Acute myeloid leukaemia (AML) in adults unable to undergo intensive chemotherapy 3. Certain non-Hodgkin lymphoma types, in combination with other medications |
References
Disclaimer
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Author Details
Written By
Naina Boruah
MSc Biomedical Science
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 19 Aug 2026 | 06:50 AM (IST)
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