Venclexta 100mg Tablet is used for:

• Chronic lymphocytic leukaemia (CLL), including specific treatment settings based on previous therapy and disease characteristics.

• Acute myeloid leukaemia (AML) in adults who are not eligible for intensive chemotherapy, in combination with other prescribed medicines.

Venclexta contains venetoclax, a selective BCL-2 inhibitor.

BCL-2 is a protein that helps certain blood cancer cells avoid programmed cell death. Venetoclax blocks this protein, allowing the cancer cells to undergo apoptosis, which helps reduce the number of cancer cells.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take.

• Strong CYP3A inhibitors: These medicines can increase venetoclax levels and may require dose adjustment or avoidance during the initial dose ramp-up.

• Strong CYP3A inducers: These medicines can reduce the effectiveness of Venclexta and should generally be avoided.

• P-glycoprotein (P-gp) inhibitors: These may increase venetoclax exposure.

• Medicines affected by P-gp or BCRP: Venetoclax may increase their exposure.

• Grapefruit, Seville oranges and starfruit: Avoid these during treatment because they can increase venetoclax levels.

Do not start any new medicine without informing your doctor.

• Store at a temperature not exceeding 30°C.

• Keep the tablets in their original packaging to protect them from moisture.

• Keep out of the sight and reach of children.

Take Venclexta exactly as prescribed by your doctor.

• Take the tablet once daily with a meal and water.

• Swallow the tablet whole without crushing, chewing or breaking it.

• Your doctor may gradually increase the dose during the initial treatment period to reduce the risk of tumour lysis syndrome.

• Drink plenty of fluids as advised during the dose ramp-up period.

• If you miss a dose and remember within 8 hours, take it as soon as possible. If more than 8 hours have passed, skip the missed dose.

• If you vomit after taking a dose, do not take another dose on the same day.

Common side effects

• Neutropenia

• Anaemia

• Low platelet count

• Diarrhoea

• Nausea

• Fatigue

• Constipation

• Vomiting

• Fever

• Reduced appetite

Serious side effects

Seek medical attention immediately if you develop:

• Tumour lysis syndrome (TLS)

• Serious infections

• Severe neutropenia

• Significant bleeding

• Kidney problems related to TLS

• Follow the dose-escalation schedule exactly as prescribed.

• Drink plenty of fluids during the initial treatment period.

• Attend all scheduled blood tests and monitoring appointments.

• Report fever, chills or signs of infection immediately.

• Avoid grapefruit, Seville oranges and starfruit during treatment.

• Do not receive live vaccines unless advised by your doctor.

• Do not stop treatment without consulting your oncologist.