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Venclexta 10mg Tablet
Prescription Required
Salt Composition : Venetoclax
Manufacturer : ABBVIE THERAPEUTICS INDIA PRIVATE LIMITED
Origin of Medicine : United States of America
2 Tablet(s) In A Strip
Introduction to Venclexta 10mg Tablet
Venclexta 10mg Tablet contains the active ingredient Venetoclax. Venclexta 10mg Tablet is an antineoplastic drug that belongs to the class of BCL-2 inhibitors. It is used to treat adults with certain types of blood cancers, including chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML).
Specifically, it is used in CLL with a 17p deletion and in AML in patients who cannot undergo intensive chemotherapy. Additionally, it can be used in combination with other medications to treat certain types of non-Hodgkin lymphoma.
Venclexta 10mg Tablet works by inhibiting the BCL-2 protein, which helps promote cancer cell death. This action restores the process of apoptosis (programmed cell death) by binding to BCL-2, displacing pro-apoptotic proteins, and initiating mitochondrial outer membrane permeabilisation, which triggers cell death.
Do not take Venclexta 10mg Tablet if you are allergic to Venetoclax or any of the other ingredients in the medication. Before starting treatment, inform your doctor if you have kidney problems, a history of infections, or any blood-related disorders like low white blood cell count or low platelet count.
Ensure that your physician is aware of any past history of Tumor Lysis Syndrome (TLS) or if you are pregnant or planning to become pregnant, as Venclexta may harm the fetus. Venclexta 10mg Tablet should not be used in children or adolescents under the age of 18.
Uses of Venclexta 10mg Tablet
Venclexta 10mg Tablet is used in the treatment of the following:
- Chronic lymphocytic leukaemia (CLL), including CLL with 17p deletion
- Acute myeloid leukaemia (AML) in adults who cannot undergo intensive chemotherapy
- Certain types of non-Hodgkin lymphoma, when combined with other medications
Therapeutic Effects of Venclexta 10mg Tablet
Venclexta 10mg Tablet works as a selective, orally bioavailable small-molecule inhibitor of BCL-2, an antiapoptotic protein. In CLL and AML cells, BCL-2 overexpression supports tumour cell survival and chemotherapy resistance by binding directly to BCL-2, Venclexta 10mg Tablet displaces pro-apoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilisation and activating caspases. Nonclinical studies demonstrate venetoclax’s cytotoxic effect on tumor cells overexpressing BCL-2.
Interaction of Venclexta 10mg Tablet with other drugs
It is important to inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Venclexta 10mg Tablet, potentially affecting their effectiveness or causing side effects.
More Information about Venclexta 10mg Tablet
- Keep out of reach of children and pets.
- Store Venclexta 10mg Tablet in the original packaging to protect from moisture.
- Avoid direct sunlight
- Store Venclexta 10mg Tablet at a temperature not exceeding 30°C.
How to consume Venclexta 10mg Tablet
Venclexta 10mg Tablet is administered orally. Do not break, chew, or crush the tablets. Follow the prescribed dosing schedule and consult your healthcare provider to determine the correct dosage. If you miss a dose, do not double the dose. Contact your healthcare provider for guidance.
Safety Advices for Venclexta 10mg Tablet
Pregnancy
It is unsafe to consume Venclexta 10mg Tablet during pregnancy as it may cause harm to the fetus when administered to pregnant women.
Breast Feeding
It is unknown if Venclexta 10mg Tablet are safe to take during breastfeeding. Please consult your healthcare provider if you have any concerns.
Lungs
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Venclexta 10mg Tablet.
Liver
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Venclexta 10mg Tablet.
Alcohol
It is unknown whether alcohol consumption is safe while you are undergoing a Venclexta 10mg Tablet course. It is recommended to consult your doctor for better guidance.
Driving
Venclexta 10mg Tablet has no or negligible influence on the ability to drive and use machines, so it is generally safe to use.
Side Effects of Venclexta 10mg Tablet
Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.
Common side effects of Venclexta 10mg Tablet are
- Fatigue
- Anemia
- Nausea
- Diarrhea
- Low platelet count (thrombocytopenia)
- Low white blood cell count (neutropenia)
Serious side effects of Venclexta 10mg Tablet are:
- Risk of death
- Tumor lysis syndrome (TLS)
- Kidney failure
- Need for dialysis treatment
Word of Advice
Venclexta 10mg Tablet can cause serious side effects like Tumor Lysis Syndrome (TLS), neutropenia, and infections, requiring close monitoring and prophylactic treatment, especially during the ramp-up phase. It may also harm the fetus, so women of reproductive potential should avoid pregnancy during treatment. Regular blood counts are essential to detect neutropenia and live attenuated vaccines should be avoided. Follow your healthcare provider’s instructions carefully, stay hydrated, and notify your doctor immediately if you experience symptoms like fever or unusual tiredness.
FAQs
Q 1. What is the new cancer drug Venclexta 10mg Tablet?
Venclexta 10mg Tablet is a cancer drug used to treat certain blood cancers, including chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML). It works by inhibiting the BCL-2 protein, which helps cancer cells survive, promoting their death.
Q 2. What type of chemo is Venclexta 10mg Tablet?
Venclexta 10mg Tablet is not a traditional chemotherapy drug. It is a targeted therapy that inhibits the BCL-2 protein to promote the death of cancer cells.
Q 3. How successful is Venclexta 10mg Tablet?
Venclexta 10mg Tablet has shown significant success in treating chronic lymphocytic leukaemia (CLL) and acute myeloid leukaemia (AML), especially in patients with high-risk forms of these cancers. Clinical studies demonstrate improved survival rates and remission in many patients.
Q 4. Does Venclexta 10mg Tablet lower platelets?
Yes, Venclexta 10mg Tablet can lower platelet counts, leading to thrombocytopenia in some patients. Regular blood tests are needed to monitor platelet levels during treatment.
Q 5. Does Venclexta 10mg Tablet cause side effects?
Yes, Venclexta 10mg Tablet can cause side effects. Common ones include nausea, diarrhoea, fatigue, and low blood cell counts. It can also lead to more serious effects, such as tumour lysis syndrome (TLS) and infections. Regular monitoring by a healthcare provider is essential to manage and prevent complications.
Fact Box of Venclexta 10mg Tablet
| Molecule name: Venetoclax | Therapeutic class: Antineoplastic agent
|
| Pharmacological class: BCL-2 inhibitor | Indications: 1. Chronic lymphocytic leukaemia (CLL), including CLL with 17p deletion 2. Acute myeloid leukaemia (AML) in adults unable to undergo intensive chemotherapy 3. Certain non-Hodgkin lymphoma types, in combination with other medications |
References
1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208573s013lbl.pdf
2. Juárez-Salcedo LM, Desai V, Dalia S. Venetoclax: evidence to date and clinical potential. Drugs Context. https://pmc.ncbi.nlm.nih.gov/articles/PMC6788387/
3. Waggoner M, Katsetos J, Thomas E, Galinsky I, Fox H. Practical Management of the Venetoclax-Treated Patient in Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia. https://pmc.ncbi.nlm.nih.gov/articles/PMC9214960/
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