• Directly inhibits the growth and spread of cancer cells in conditions like advanced renal cell carcinoma.
• Helps to reduce the size and impact of tumors in conditions such as soft tissue sarcoma.

Votrient 400mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Votrient 400mg  tablet and reduce its effectiveness by causing undesirable side effects.

• Store Votrient 400mg tablet in room temperature (25°C)
• Keep the injection away from the reach of children and pets.
• If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.
• Take only a partial dose to make up for a forgotten dose.

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Votrient 400mg tablet at least two hours after a meal or one hour before a meal. 

It is crucial to monitor any adverse effects and report them to your healthcare provider for appropriate management. 

 Common

• Hypertension
• Hair color change
• Increased glucose levels
• Decreased weight, decrease in appetite
• Diarrhea
• Nausea, vomiting
• Muscle and joint pain
• Headache
• Shortness of breath
• Tiredness

Serious

• Heart problems
• Bleeding from the anus, mouth
• Hypothyroidism
• Interstitial lung disease
• Infections

Avoid consuming grapefruit juice while undergoing treatment with this medication, as it could heighten the risk of side effects. Male patients whose partners are of childbearing potential should use effective contraception during treatment and for at least two weeks after the final dose to prevent pregnancy. It is important to take the tablet consistently at the same time each day. Your doctor will conduct regular lab tests to monitor the effectiveness of the medication.

1. Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
2. Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
3. Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.