Xmab 100mg Injection is used in the treatment of the following:

• Non-Hodgkin's lymphoma (NHL)
• Chronic lymphocytic leukaemia (CLL)
• Rheumatoid Arthritis
• Granulomatosis with polyangiitis or microscopic polyangiitis
• Pemphigus Vulgaris

Xmab 100mg injection  is a monoclonal antibody that targets the antigen CD20 expressed on the cell surface of B-lymphocytes (a type of white blood cells). When this medicine binds to the B-cell, it induces cell death in NHL and CLL. The binding action blocks cell activation and growth and cause anticancer effects. It inhibits rheumatoid factor production, antigen presentation, T-cell activation, and proinflammatory cytokine production in rheumatoid arthritis. 

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. In particular, tell your doctor if you are taking medicines for blood pressure or other heart conditions. Certain medications may interact with Xmab 100mg injection and reduce its effectiveness by causing undesirable side effects. 

• Store Xmab 100mg injection  in the refrigerator (2°C to 8°C)
• Do not freeze
• keep the injection away from the reach of children and pets.
• If you have missed any dosing appointments, inform your doctor and schedule immediately.

It should only be administered by a trained doctor or nurse. Do not self-administer the injection. Before giving Xmab 100mg injection, you will be given other medications (pre-medication) to reduce the possible side effects. Your doctor will decide the dose and duration of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for any unwanted side effects.  

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Xmab 100mg Injection include:

• Headache & nausea
• Diarrhea
• Bronchitis
• Depression
• Fever & chills
• Lymphopenia (low lymphocyte count)
• Infection
• Asthenia (weakness)
• Muscle spasms
• Upper respiratory tract infection
• Changes in liver enzyme values
• Infusion-related reactions

Serious side effects of Xmab 100mg Injection include:

• Kidney problems (severe toxicity or failure)
• Progressive multifocal leukoencephalopathy (PML, a brain infection)
• Cardiovascular issues (life-threatening arrhythmias)
• Tumor lysis syndrome (kidney failure, electrolyte imbalances)
• Hepatitis B reactivation
• Skin reactions (blisters, severe rashes, or peeling skin)
• Serious infections (bacterial, fungal, or viral)
• Severe infusion reactions (breathing difficulties, low blood pressure, heart problems)

Avoid vaccines before and during therapy with Xmab 100mg injection, as it may cause drug-induced immunosuppression. Inform your physician if you have received a recent vaccine or have an active infection during treatment. Do not get vaccinated with live virus vaccines before or during treatment if you have rheumatoid arthritis. Report any symptoms like chest pain, breathing difficulties, stomach pain, or skin reactions to your doctor immediately. If you have kidney disease, inform your physician, as limited information is available on the safety of this medicine in renal failure patients. Regularly monitor your blood counts and kidney function during treatment.

1. HIGHLIGHTS OF PRESCRIBING INFORMATION. (2021). Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/103705s5464lbl.pdf  [Accessed 9 Mar. 2023].
2. ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (2020). Available at: https://www.ema.europa.eu/en/documents/product-information/mabthera-epar-product-information_en.pdf  [Accessed 9 Mar. 2023].
3. Ahmed A. Negm & Daniel E. Furst, Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 642-666