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Xolnic 4mg Injection
Last updated on 16 Jul 2026 | 07:10 AM (IST)
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Xolnic 4mg Injection
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ZOLEDRONIC ACIDMarketer
KHANDELWAL LABORATORIES PVT LTD
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Introduction to Xolnic 4mg Injection
Xolnic 4mg contains the active substance Zoledronic Acid. It belongs to the group of substances called bisphosphonates. It is used to reduce the amount of calcium in the blood in adult patients where it is too high due to the presence of a tumor. Tumors can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumor-induced hypercalcemia (TIH). It is also used to prevent bone complications in adult patients with multiple myeloma and bone metastases from solid tumors (spread of cancer from the primary site to the bone), in addition to standard cancer therapy.
Xolnic 4mg is also indicated to prevent or treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause. It is also used to treat osteoporosis in men. It is used to treat Paget’s disease of bone (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken). Other uses include treating or preventing osteoporosis in men and women taking glucocorticoids (a corticosteroid medication that may cause osteoporosis).
Do not take this injection if you are allergic to zoledronic acid, another bisphosphonate, or any other ingredients of this medicine and if you are pregnant or breastfeeding. Before initiating the treatment, inform your physician if you have kidney or liver problems, bone diseases, pain, swelling, or jaw numbness. This medicine is not recommended for use in adolescents and children below the age of 18 years. Xolnic 4mg is not cancer chemotherapy and will not slow or stop the spread of cancer. However, it can be used to treat bone diseases in patients with cancer.
Uses of Xolnic 4mg Injection
- Treat hypercalcemia of malignancy
- Multiple myeloma
- Bone metastases from solid tumors
- Osteoporosis in postmenopausal women
- Osteoporosis in men
- Paget’s disease of bone
Therapeutic Effects of Xolnic 4mg Injection
Xolnic 4mg primarily inhibits bone resorption. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.
Interaction of Xolnic 4mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications like aminoglycosides, loop diuretics, and nephrotoxic drugs may interact with Xolnic 4mg and reduce its effectiveness by causing undesirable side effects.
More Information about Xolnic 4mg Injection
- Store Xolnic 4mg at room temperature (20°C to 25°C)
- keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Xolnic 4mg Injection
It should only be administered by a trained doctor or nurse. It will be given as a drip (infusion) into your vein. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors. Do not self-administer the medication.
Safety Advice for Xolnic 4mg Injection
Breast Feeding
Breastfeeding is not recommended in patients taking Xolnic 4mg because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
Caution is advised when consuming alcohol with Xolnic 4mg. Please consult your doctor.
Liver
It is unknown whether Xolnic 4mg can be used in patients with liver disorders. Inform your physician if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Xolnic 4mg can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
It is unsafe to drive or operate heavy machinery after using Xolnic 4mg as this medicine causes drowsiness and sleepiness.
Pregnancy
Xolnic 4mg is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Side Effects of Xolnic 4mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Nausea, vomiting
- Fatigue
- Anemia
- Bone pain
- Constipation, diarrhea
- dyspnea, and fever
- Swelling in the legs and feet
- Decreased weight
- Abdominal pain
- Muscle pain
- Tiredness
Serious
- Changes in heart rhythm
- Severe hypersensitivity skin reactions
- Decreased calcium levels
- Severe bone pain
- Severe kidney problems
- Unusual fractures of the bone
Word of Advice
While being treated with zoledronic you should maintain good oral hygiene and receive routine dental check-ups. Contact your doctor or dentist immediately if you experience any problems with your mouth or teeth, such as loose teeth, pain or swelling, non-healing sores, or discharge. Inform your physician if you have kidney problems. Your doctor may advise you to take certain blood tests regularly to check the effectiveness of the therapy.
FAQs about Xolnic 4mg Injection
Q1.
What symptoms should I notify the doctor of when taking Xolnic 4mg?
Notify your healthcare provider immediately if you experience symptoms of hypocalcemia (low calcium levels), such as muscle spasms, twitches, cramps, or numbness or tingling in fingers, toes, or the area around your mouth. You should also notify your doctor if you experience symptoms of a fracture or severe bone, joint, or muscle pain.
Q2.
Can Xolnic 4mg affect the heart?
Severe side effects of Xolnic 4mg include cardiovascular problems like atrial fibrillation, bradycardia, hypotension, or hypertension.
Q3.
Is Xolnic 4mg toxic to the liver?
Limited information is available on the liver's safety in patients receiving Xolnic 4mg. Inform your physician if you have any liver disorders.
Q4.
Does Xolnic 4mg strengthen bones?
Xolnic 4mg is an osteoporosis medication that can help strengthen your bones and reduce your risk of breaking a bone.
Q5.
Is there an alternative to Xolnic 4mg Injection?
Xolnic 4mg belongs to the class bisphosphonates. Bisphosphonates can also be given as tablets; ask your doctor about this. Inform your doctor before switching to any alternative medicines.
Fact Box of Xolnic 4mg Injection
Molecule name: Zoledronic Acid | Therapeutic class: Calcium Regulator |
Pharmacological class: Bisphosphonates | Indications: 1. Treat hypercalcemia of malignancy 2. Multiple myeloma 3. Bone metastases from solid tumors 4. Osteoporosis in postmenopausal women 5. Osteoporosis in men 6. Paget’s disease of bone |
References
- Zoledronic acid 5 mg solution for infusion - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [revised on 2017] [cited 2023 Mar 28]. Available from: https://www.medicines.org.uk/emc/product/5242/pil
- HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use zoledronic Injection safely and effectively. See full prescribing information for zoledronic Injection. zoledronic Injection for intravenous use. [Revised on 2017] [cited 2023 Mar 28]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/203231s011lbl.pdf
- KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.
Disclaimer
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 16 Jul 2026 | 07:10 AM (IST)
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