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Xpreza 100mg Injection
Salt Composition : Azacitidine
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
by NATCO PHARMA LTD
Introduction to Xpreza 100mg Injection
Xpreza 100mg Injection for injection is used for treating adults with Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) if they are considered ineligible for stem cell transplant. In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer that is caused by the release of incompletely formed blood cells into the bloodstream.
Uses of Xpreza 100mg Injection
- Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
- Intermediate-2 and High-risk Myelodysplastic syndrome (MDS)
Therapeutic Effects of Xpreza 100mg Injection
In MDS and AML, the development of tumor cells is caused by the process of transcriptional repression of various genes, which is due to hypermethylation of DNA. Transcriptional repression is a process where proteins bind directly or indirectly to DNA and control the activity of copying a specific gene or a set of genes. The active form of Xpreza 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.
Interaction of Xpreza 100mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Xpreza 100 mg injection and cause undesirable side effects.
More Information about Xpreza 100mg Injection
Store at room temperature (15-30°C). If the product is reconstituted, it must be used immediately; if not, store at 2-8°C for not more than 8 hours. Keep the injection out of sight and reach of children.
How to consume Xpreza 100mg Injection
Take Xpreza 100mg Injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight and general condition. Xpreza 100mg Injection shall be given under the skin of your thigh, stomach or upper arm.
Safety Advices for Xpreza 100mg Injection
Xpreza 100mg Injection could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.
Breastfeeding is not intended for patients on Xpreza 100mg Injection therapy. Consult your physician for advice.
It is not known whether it is safe to administer Xpreza 100mg Injection in lung failure patients. Please consult your doctor.
Inform your physician if you have been told that you have a tumor in the liver cells.
It is not known whether it is safe to consume alcohol with Xpreza 100mg Injection. Please consult your doctor.
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Xpreza 100 mg injection.
Side Effects of Xpreza 100mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Unexpected bleeding, with blood in stool and urine
- Pneumonia, characterized by chest pain or breathlessness.
- Allergic reaction with symptoms of swelling of lips, itching, or rashes.
- Seizures, loss of consciousness, severe headache, or bleeding in the brain
- Frequent urination with pain or burning sensation
- Disturbances in the blood count (RBC, WBC, Platelets)
- Nausea, vomiting, diarrhea
- Skin reactions like redness and pain at the site of injection
- Decreased appetite
- Pain in extremities
- Joint pain
- Stomach pain
- Sore nose and throat
- Rashes and bruising
Word of Advice
Inform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this injection as they worsen the condition. Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects on the developing baby. Take this injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. It is administered under the skin of your thigh, stomach, or upper arm.
Q 1. How to use Xpreza 100 mg Injection?
Take Xpreza 100 mg Injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. Xpreza 100 mg Injection is administered under the skin of your thigh, stomach or upper arm.
Q 2. Does Xpreza 100 mg Injection cause hair loss?
No, Xpreza 100 mg Injection does not cause hair loss even after using it for a prolonged period of time.
Q 3. How does Xpreza 100 mg Injection work?
Xpreza 100 mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.
Q 4. Is Xpreza 100 mg Injection chemotherapy?
Yes, Xpreza 100 mg Injection is chemotherapy, and it is used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).
Q 5. What are the side effects of Xpreza 100 mg Injection?
The common side effects of Xpreza 100 mg Injection are Nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of the skin, dizziness, joint pain, headache, sore throat, and nose.
Q 6. Is it safe to drive after taking an Xpreza 100 mg Injection?
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking this medication.
Fact Box of Xpreza 100mg Injection
Molecule name: Azacitidine
|Therapeutic class: Anti-metabolites|
Pharmacological class: Anti-Neoplastics
1. Treat advanced or metastatic non-small lung cancer (NSCLC),
2. To Treat Advanced or metastatic pancreatic cancer.
- K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741, [Accessed on 5th Apr 2021] https://www.researchgate.net/publication/7094896_Transcriptional_repression_in_eukaryotes_Repressors_and_repression_mechanisms
- Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018 [Accessed on 3rd Apr 2021] https://bmchematol.biomedcentral.com/articles/10.1186/s12878-017-0094-8
- Dr.Reddy’s Laboratories, [Revised on 8th Nov 2018] [Accessed on 5th Apr 2021] https://www.drreddys.com/media/743001/ac-pm-english.pdf
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