• Treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency in adults
• Prophylaxis of headaches in adult patients with chronic migraine
• Treatment of spasticity (abnormal increase in muscle) in adult patients
• Treatment of cervical dystonia in adult patients
• Treatment of severe axillary hyperhidrosis (increased amount of sweat production) in adult
• Treatment of blepharospasm (abnormal spasm of eyes) associated with dystonia in patients
• Treatment of strabismus (abnormal alignment of the eyes) in patients

Zarbot 100IU injection interacts with proteins in the muscles and exocrine glands and blocks the release of Acetylcholine (ACh) into the space between neurons. This process inhibits cholinergic nerves' overactivity and reduces cholinergic transmission. When locally injected, it suppresses the overactive nerves and relieves spasms and neurological conditions.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Zarbot 100IU injection and can cause undesirable side effects. 

• Keep out of sight and reach of pets and children.
• Do not freeze the medicine.
• Store in a refrigerator (2°C – 8°C), or store in a freezer (-5°C to -20°C).

Zarbot 100IU injection will be administered to you by a healthcare professional in a hospital setting. It is usually injected into muscles, the bladder wall, or the skin. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious

• Dizziness
• Upper respiratory infection
• Urinary tract infection
• Low urine output
• Difficulty swallowing, speaking, or breathing.
• Allergic reactions

Common

• Irritation, pain, or bleeding at the area of injection
• A sprain in the ligament
• Hypertonia
• Pruritus, dermatitis, and rash
• Muscle weakness and pain in extremities
• Fever
• Dry mouth and nausea

Heart patients should take Zarbot 100IU injection cautiously and inform their doctor about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Possible side effects of BOTOX injections include infection, pain, swelling, sensitivity, tenderness, redness, and bleeding at the injection site. Overuse or high doses may reduce effectiveness and produce antibodies. 

Reduced blinking may require additional eye care. BOTOX does not prevent headaches in episodic migraine. Eyelid drooping may occur after treatment for facial lines. Do not breastfeed or get pregnant while taking Zarbot 100IU injection. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.

1. AbbVie Ltd., Electronic Medicines Compendium (EMC), [Revised on April 2023] [Accessed on 15th June 2023],*BOTOX consolidated PIL UK LL TC (medicines.org.uk)
2. Allergan Pharmaceuticals Ireland, US Food and Drug Administration; [Revised on April 2017] [Accessed on 15th June 2023], BOTOX (onabotulinumtoxinA) for injection, for intramuscular (fda.gov) 
3. Mark S. Nestor, David Arnold, Daniel Fischer, The mechanisms of action and use of botulinum neurotoxin type A in aesthetics: Key Clinical Postulates II, Journal of Cosmetic Dermatology, 13th Aug 2020, 19:11, 2785-2804, [Accessed on 8th Apr 2021] https://onlinelibrary.wiley.com/doi/10.1111/jocd.13702