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Zemdri Injection
Prescription Required
Salt Composition : Plazomicin
Manufacturer : CIPLA LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Zemdri Injection
Zemdri Injection is an advanced aminoglycoside antibiotic used for treating serious bacterial infections. It contains the active molecule Plazomicin, which is primarily indicated for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis, caused by certain multidrug-resistant (MDR) gram-negative bacteria. It may also be used in other off-label resistant infections under expert medical supervision.
Inform your physician if you have a history of kidney problems, hearing loss, or neurological disorders. Do not take this medicine if you are allergic to Plazomicin or other aminoglycosides. Your doctor will monitor kidney function and drug levels during treatment.
Uses of Zemdri Injection
- Treatment of complicated urinary tract infections (cUTIs), including pyelonephritis
- May be used in certain multidrug-resistant gram-negative infections when other antibiotics are ineffective
Therapeutic Effects of Zemdri Injection
Zemdri Injection exerts its antibacterial effect by binding to bacterial 30S ribosomal subunits, inhibiting protein synthesis, and ultimately leading to cell death. It is bactericidal in nature and effective against pathogens resistant to other aminoglycosides due to its structural modification, which helps evade inactivating enzymes.
Interaction of Zemdri Injection with other drugs
Inform your doctor about all medications, including over-the-counter drugs, vitamins, and herbal supplements you are taking. Drugs that may interact with Zemdri Injection include:
- Loop diuretics (e.g., furosemide)
- Other nephrotoxic or ototoxic drugs (e.g., vancomycin, amphotericin B, cisplatin)
- Neuromuscular blocking agents
These interactions may increase the risk of toxicity. Your doctor will consider dosage adjustments or alternative medications accordingly.
More Information about Zemdri Injection
- Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C.
- Keep out of reach of children.
- Use within prescribed expiration after opening or dilution, as instructed by a healthcare provider.
How to consume Zemdri Injection
Zemdri Injection is administered via intravenous infusion over 30 minutes, typically once daily. It should only be given by a qualified healthcare professional in a clinical setting. Do not self-administer.
Safety Advices for Zemdri Injection
Pregnancy
Zemdri Injection should only be used during pregnancy if absolutely necessary. It may pose a risk of fetal harm. Discuss risks vs benefits with your physician.
Breast Feeding
It is unknown whether Plazomicin is excreted in human milk. Caution is advised; consult your doctor before breastfeeding during treatment.
Lungs
There are no specific concerns regarding lung impairment, but inform your doctor if you have respiratory issues.
Liver
No dose adjustment is typically required for hepatic impairment, but inform your physician of any liver conditions.
Alcohol
Avoid consuming alcohol during treatment as it may worsen dizziness or increase kidney-related side effects.
Driving
Avoid driving or using heavy machinery if you feel lightheaded, dizzy, or tired during treatment.
Side Effects of Zemdri Injection
Common side effects:
- Nausea
- Diarrhea
- Headache
- Dizziness
- Increased creatinine levels (a marker of kidney function)
Serious side effects:
- Kidney damage (nephrotoxicity)
- Hearing loss or ringing in the ears (ototoxicity)
- Balance issues or vertigo
- Allergic reactions such as swelling, rash, or trouble breathing
Anyone experiencing serious side effects should seek immediate medical help.
Word of Advice
Since this drug is given by a healthcare provider in a clinical setting, patients should make sure to attend all scheduled doses and follow-up appointments. Do not skip or stop treatment early, even if symptoms improve, as this can lead to incomplete recovery and increased resistance. Let your doctor know about any unusual symptoms during the treatment. Avoid self-medicating or taking over-the-counter drugs without informing your healthcare team, especially painkillers like ibuprofen that may affect kidney function.
FAQs
Q 1. What is the drug Zemdri Injection used for?
Zemdri Injection is used to treat serious bacterial infections, especially complicated urinary tract infections and some bloodstream infections. It is helpful when other antibiotics don’t work due to drug resistance. Doctors usually use it in hospital settings for severe cases.
Q 2. Is Zemdri Injection available in India?
As of now, Zemdri Injection is not widely available in India and may not be stocked by most pharmacies. It might be accessible through special import or on a named-patient basis in select hospitals. Always check with a doctor or hospital pharmacy for availability.
Q 3. Does Zemdri Injection cover Pseudomonas?
Zemdri Injection is not effective against Pseudomonas aeruginosa. For infections caused by Pseudomonas, other antibiotics like piperacillin-tazobactam or meropenem are usually preferred.
Q 4. Is Zemdri Injection in pregnancy category?
Zemdri Injection is classified under Pregnancy Category D, which means it may harm the unborn baby if used during pregnancy. It should only be used when absolutely necessary and under strict medical supervision. Pregnant women should inform their doctor before starting this medicine.
Fact Box of Zemdri Injection
Molecule name: Plazomicin
| Therapeutic class: Antibacterial agents |
| Pharmacological class: Aminoglycoside antibiotic | Indications: 1. Complicated urinary tract infections (cUTIs) 2. Infections caused by multidrug-resistant gram-negative bacteria |
References
Disclaimer
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