The acetylcysteine + pyridoxamine dihydrochloride is approved for medical use to treat diabetic nephropathy and as an antidote for paracetamol poisoning.

It is used in the management of diabetic nephropathy and as an antidote for paracetamol poisoning. Diabetic nephropathy is a crucial factor leading to end-stage kidney disease. It is a result of various factors such as poor glycaemic control, prolonged diabetes, hypertension, family history, and other complications. This medicine protects the kidney from injury caused by contrast media, ischemia and toxins. It also detoxifies the body from the effects of over-dosage of paracetamol.

Take acetylcysteine + pyridoxamine dihydrochloride as your physician advises. Swallow the tablets whole and intact. This capsule should be taken with food. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.

The common side effects that are experienced while you are on the treatment with acetylcysteine + pyridoxamine dihydrochloride is nausea, vomiting and diarrhea. Report your doctor immediately, if you experience any allergic reaction like allergic reaction (difficulty with breathing, chest tightness, rash, itching, hives, swelling in the lips, tongue, or face), fever and chills, mouth or skin blisters, stomach ache.

Individuals with allergic reactions to the ingredients and severe infections should consult their doctor before taking the medicine. Talk to your doctor immediately if you have any allergic reaction (difficulty with breathing, chest tightness rash, itching, hives, swelling lips, tongue, or face), infection (short- or long-term), tuberculosis, intestinal ulcers or diverticulitis (small bulging pouches developed in the digestive tract), liver disease, cancer, kidney function problems, and persistent headaches.

Talk to your doctor if you have recently been vaccinated or are planning a vaccination because a certain vaccination (live vaccine) should not be given while taking acetylcysteine + pyridoxamine dihydrochloride medicine. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while you are breastfeeding.

Your doctor will advise you to check the blood if you have low white blood cells, platelets, or elevated liver enzymes before giving you the medicine. Drink plenty of water and take electrolytes to compensate for the water loss due to vomiting.

1. Alniche Life Sciences Pvt Ltd., [Revised on 2021] [Accessed on Nov 2023], https://www.alniche.com/product/renosave/
2. Panpharma GmbH. Electronic Medicines Compendium (EMC), [Revised on December 2019] [Accessed on Nov 2023], pil.3447.pdf (medicines.org.uk)
3. Parvin Mazraati and Mohsen Minaiyan, Hepatoprotective Effect of Metadoxine on Acetaminophen-induced Liver Toxicity in Mice, Published on 24 april 2014, [Accessed on Nov 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952541/
4. E.R. Pearson, R.J. McCrimmon, Diabetes mellitus, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 797-836.

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.