The U.S. FDA approved Conjugate Estrogen for Hormone replacement therapy on July 1st, 2003. Conjugate Estrogen belongs to the medication class known as estrogen. 

Conjugated estrogen is used to treat menopausal symptoms in and around the vagina (such as itching, dryness, burning, and pain). It treats painful intercourse caused by menopausal changes in the vagina.

For external use only. It is important to apply enough cream evenly on the affected area that needs treatment and gently massage it into the skin until it is fully absorbed. Avoid contact with eyes. Apply Conjugate Estrogen as your doctor recommends. 

The most common side effects of Conjugate Estrogen are headache, breast pain, irregular vaginal bleeding or spotting, abdominal cramps, bloating, nausea, vomiting, hair loss, fluid retention, and vaginal yeast infection. Serious side effects while taking Conjugate Estrogen are serious allergic reactions. 

Do not take Conjugate Estrogen if you are allergic to Conjugate Estrogen, or any of its ingredients. Do not initiate the use of this medicine if you experience unusual vaginal bleeding, have a history of certain cancers, including breast or uterine cancer, have had a stroke or heart attack, suffer from blood clot issues, have liver problems, a diagnosed bleeding disorder. Consult your healthcare provider if you have or have had cancer before considering the use of this medicine. If you suspect pregnancy, avoid using the cream.

Inform your doctor about any unusual vaginal bleeding, as postmenopausal vaginal bleeding could indicate uterine cancer. Share your complete medical history, especially conditions like asthma, epilepsy, diabetes, migraine, endometriosis, lupus, heart, liver, thyroid, kidney issues, or elevated blood calcium levels. Disclose all medications, including prescriptions, non-prescriptions, vitamins, and herbs, as interactions with Conjugate Estrogen are possible. If you are planning for surgery or bed rest, consult your healthcare provider, and if breastfeeding, be aware that the cream's estrogen hormones may pass into breast milk. Also, notify your physician about any gallbladder disease risk, as estrogens can elevate this risk. Discontinue estrogen use if severe hypercalcemia, vision loss, extreme hypertriglyceridemia, or cholestatic jaundice arises. For women on thyroid replacement therapy, closely monitor thyroid function.

Follow the prescribed dosage and usage instructions provided by your healthcare professional. Inform your doctor about any known allergies or medical conditions you have before receiving Conjugate Estrogen. If you notice any unexpected or severe side effects, like an allergic reaction, seek immediate medical attention. Inform your healthcare professional about any other medications or supplements you are consuming to avoid potential drug interactions. If you have any concerns regarding the treatment, consult your healthcare professional for information.

1. Pfizer Limited, [Revised on Sept 2018] [ Accessed on 31th August 2023], http://labeling.pfizer.com/showlabeling.aspx?id=132&section=PPI
2. Pfizer, US Food and Drug Administration, [Revised on Dec 2015] [ Accessed on 31th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020216s083lbl.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Estrogens, progestins, and contraceptives, 7th edition, 2013, 308 - 310.
4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Estrogens and progestins, 12th edition, 2011, 1175.

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.