Cyproterone and Ethinyl Estradiol is a combination drug primarily used to treat androgen-dependent conditions, including acne, hirsutism, and certain types of hormonal imbalances in women. This combination also functions as a contraceptive by preventing ovulation.

Cyproterone, a synthetic anti-androgen and progestogen, was first developed in the 1960s, and its approval for medical use followed in the subsequent decades. Ethinyl Estradiol, a synthetic form of estrogen, has been widely used in oral contraceptives since its FDA approval in 1943. Clinical trials on the combination have demonstrated its efficacy in treating androgen-related conditions while maintaining contraceptive reliability. Approval timelines vary worldwide, with the drug being widely available in Europe and other regions since the late 1980s.

• Acne Treatment: Reduces sebum production and treats severe acne that has not responded to other therapies.
• Hirsutism: Manages excessive hair growth in women caused by androgen imbalance.
• Polycystic Ovary Syndrome (PCOS): Balances hormones and regulates menstrual cycles.
• Contraception: Prevents unintended pregnancy while addressing hormonal concerns.

Cyproterone and Ethinyl Estradiol are available as an oral tablet, typically in a 21-day regimen followed by a 7-day break or placebo phase to allow withdrawal bleeding. The standard dosage includes:

• Cyproterone Acetate: 2 mg
• Ethinyl Estradiol: 35 µg

The dosage may vary depending on the condition being treated, so it's essential to follow the prescribing physician's recommendations.

Common: 

• Nausea
• Headaches
• Breast tenderness
• Mood changes
• Weight fluctuations

Serious

• Blood clots
• Liver dysfunction
• Jaundice
• Hypertension
   

In case of severe side effects, consult a healthcare provider immediately.

• Thrombosis Risk: Increased risk of blood clots, especially in women with a history of thromboembolic disorders or smoking.
• Liver Conditions: Avoid in patients with active liver disease or hepatic dysfunction.
• Breast Cancer: A small increased risk has been associated with combined hormonal contraceptive use.

• Pre-existing Medical Conditions: Inform your doctor if you have a history of cardiovascular diseases, migraines, or diabetes.
• Interactions: This medication may interact with certain drugs, such as anticonvulsants and antibiotics, reducing contraceptive efficacy.
• Smoking: Avoid smoking, especially if over 35 years of age, to minimise cardiovascular risks.

Cyproterone and Ethinyl Estradiol are highly effective when used as prescribed. Regular follow-ups are essential to monitor hormone levels, manage side effects, and assess the treatment's efficacy. Patients should discuss their full medical history with their physician before starting therapy.

1. https://pubmed.ncbi.nlm.nih.gov/28463030/
2. https://go.drugbank.com/drugs/DB04839
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4049993/

The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to determine if you are eligible to receive this treatment.