This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Cyproterone and Ethinyl Estradiol is a combination drug primarily used to treat androgen-dependent conditions, including acne, hirsutism, and certain types of hormonal imbalances in women. This combination also functions as a contraceptive by preventing ovulation.
Cyproterone, a synthetic anti-androgen and progestogen, was first developed in the 1960s, and its approval for medical use followed in the subsequent decades. Ethinyl Estradiol, a synthetic form of estrogen, has been widely used in oral contraceptives since its FDA approval in 1943. Clinical trials on the combination have demonstrated its efficacy in treating androgen-related conditions while maintaining contraceptive reliability. Approval timelines vary worldwide, with the drug being widely available in Europe and other regions since the late 1980s.
Mechanism of Action of undefined
Cyproterone works by binding to androgen receptors, blocking the effects of male hormones like testosterone. This reduces sebum production, hair growth, and other androgen-mediated processes. Ethinyl Estradiol suppresses ovulation and stabilises the endometrium by modulating gonadotropin release, ensuring hormonal balance and enhanced contraceptive efficacy. Together, they create a dual-action therapy for androgen-related conditions and effective contraception.
Uses of undefined
- Acne Treatment: Reduces sebum production and treats severe acne that has not responded to other therapies.
- Hirsutism: Manages excessive hair growth in women caused by androgen imbalance.
- Polycystic Ovary Syndrome (PCOS): Balances hormones and regulates menstrual cycles.
- Contraception: Prevents unintended pregnancy while addressing hormonal concerns.
undefined Drug administaration and Dosage available
Cyproterone and Ethinyl Estradiol are available as an oral tablet, typically in a 21-day regimen followed by a 7-day break or placebo phase to allow withdrawal bleeding. The standard dosage includes:
- Cyproterone Acetate: 2 mg
- Ethinyl Estradiol: 35 µg
The dosage may vary depending on the condition being treated, so it's essential to follow the prescribing physician's recommendations.
Warnings, Precautions and Side Effects of undefined
Warnings
- Thrombosis Risk: Increased risk of blood clots, especially in women with a history of thromboembolic disorders or smoking.
- Liver Conditions: Avoid in patients with active liver disease or hepatic dysfunction.
- Breast Cancer: A small increased risk has been associated with combined hormonal contraceptive use.
Precautions
- Pre-existing Medical Conditions: Inform your doctor if you have a history of cardiovascular diseases, migraines, or diabetes.
- Interactions: This medication may interact with certain drugs, such as anticonvulsants and antibiotics, reducing contraceptive efficacy.
- Smoking: Avoid smoking, especially if over 35 years of age, to minimise cardiovascular risks.
Side Effects
Common:
- Nausea
- Headaches
- Breast tenderness
- Mood changes
- Weight fluctuations
Serious
- Blood clots
- Liver dysfunction
- Jaundice
- Hypertension
In case of severe side effects, consult a healthcare provider immediately.
Word Of Advice
Cyproterone and Ethinyl Estradiol are highly effective when used as prescribed. Regular follow-ups are essential to monitor hormone levels, manage side effects, and assess the treatment's efficacy. Patients should discuss their full medical history with their physician before starting therapy.
Frequently Asked Question
References
Disclaimer
The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to determine if you are eligible to receive this treatment.
