Dapagliflozin, Linagliptin, and Metformin are three different diabetes medicines that work together to help control blood sugar levels in adults with type 2 diabetes.

• Dapagliflozin was first approved by the FDA in 2014.

• Linagliptin got its approval in 2011.

• Metformin has been used for decades and was approved back in the 1990s.

This combination is used when a single medicine is not enough to control blood sugar and is often recommended along with proper diet and regular exercise.

Dapagliflozin, Linagliptin, Metformin is used to:

• Control blood sugar levels in adults with type 2 diabetes mellitus

• Reduce the risk of long-term diabetes complications

• Support weight loss and improve blood pressure in some patients

This medicine is taken by mouth in the form of a tablet, usually once or twice a day as directed by your doctor.

• It is best taken with food to reduce stomach upset, especially due to Metformin.

• Swallow the tablet whole with water. Do not crush, break, or chew it.

• Your doctor will decide the correct dose depending on your blood sugar levels and health condition.

Always take the medicine at the same time each day to get the best results.

Common side effects may include:

• Nausea or upset stomach

• Increased urination

• Low blood sugar (if combined with other diabetes medicines)

• Urinary tract or genital infections

• Tiredness or weakness

Serious side effects are rare but may include lactic acidosis or dehydration. Seek medical help if you feel very weak, confused, or have trouble breathing.

• Not suitable for type 1 diabetes or diabetic ketoacidosis.

• May increase the risk of genital or urinary tract infections (especially due to Dapagliflozin).

• Can lead to low blood sugar if taken with insulin or sulfonylureas.

• Inform your doctor if you have kidney, liver, or heart problems before starting this medicine.

• Dehydration or excess alcohol use can increase the risk of serious side effects.

• Let your doctor know if you are pregnant, breastfeeding, or planning a baby.

• Drink plenty of fluids to prevent dehydration, especially during hot weather or if you are ill.

• Regularly check your kidney function and blood sugar levels while on this medicine.

• Be cautious while driving or operating machinery if you feel dizzy or weak.

• Tell your doctor about all the medicines you are taking to avoid unwanted interactions.

If you notice symptoms like stomach pain, nausea, or unusual tiredness, contact your doctor immediately.

• Always take this medicine with food to avoid stomach upset.

• Check your blood sugar levels regularly and keep a log to share with your doctor

• Stay hydrated to avoid dehydration, especially during hot weather or if you’re exercising.

• Do not stop the medicine without talking to your doctor, even if you feel better.

• Carry a sugar source (like glucose tablets) in case of low blood sugar episodes.

1. https://www.ema.europa.eu/en/medicines/human/referrals/metformin-metformin-containing-medicines

2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/201280s005lbl.pdf

3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/202293s026lbl.pdf

4. https://www.ema.europa.eu/en/medicines/human/EPAR/forxiga

The content provided here is for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition.