Glycopyrrolate, Neostigmine methylsulphate were approved by the US FDA contains two active ingredients, glycopyrrolate, and neostigmine, which belong to the anticholinergics and cholinesterase inhibitors groups, respectively. The drug has effectively reversed the action of certain muscle relaxants used in the surgery. 

Glycopyrrolate, Neostigmine methyl sulphate is used in reversing the effects of muscle relaxation. 

Glycopyrrolate, Neostigmine methyl sulphate is available in injection dosage form. It is given by a doctor or nurse into a vein and should not be self-administered. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

Like any other drug, Glycopyrrolate, Neostigmine methyl sulphate also have some side effects. The most common side effects people may experience are Dry mouth, constipation, slow heart rate (Bradycardia), irregular heartbeat, difficulty urination, frequent urination, visual disturbances, sensitive light (Photophobia), glaucoma (increased pressure in the eye). However some may develop serious side effects like Allergic reactions (Swelling of the face, lips, or throat, difficulty in breathing, rash, itching, hives, and dizziness). Keep an eye out for these signs and contact your doctor immediately if you experience any of them while receiving therapy.

It is not recommended to take this medication if you are allergic to the active substance glycopyrrolate, neostigmine, methylsulphate and its components. Patients with hepatic and renal impairment may be at increased risk of adverse effects from glycopyrrolate and neostigmine due to altered drug metabolism and clearance. Dose adjustments may be necessary in this population to prevent drug accumulation and toxicity.Careful monitoring of respiratory status and cardiovascular conditions in patients may be necessary.

Inform your doctor if you have a heart or kidney problem before taking the medicine. Discuss your prescribed and non-prescribed medicine and your previous health history with your doctor; it will be helpful for them to treat you based on your condition. Children and elderly patients should be cautious while taking this medicine. Consult your doctor if you are planning to get pregnant or think you may be pregnant while breastfeeding.

Drink plenty of water and take electrolytes to tackle the water loss caused by the drug. It is recommended to avoid chunk food, which leads to constipation. Eat a healthy diet which is rich in fiber content. This medicine is usually given after surgery to reverse the effect of muscle relaxants. It is recommended to get enough rest to achieve a speedy recovery.

1. B. Braun Melsungen AG, Electronic Medicines Compendium (EMC), [Revised on April 2019] [Accessed on 29th Dec 2023], https://www.medicines.org.uk/emc/files/pil.6599.pdf
2. Marieke Kruidering-Hall, Lundy Campbell, Skeletal Muscle Relaxants, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 474-491.

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.